Full article, available for free here: t.co/yp2WGxns69

CONCLUSIONS:

PROPOSAL: Careful assessment of alcohol use and metabolic dysfunction in individuals with suspected steatotic liver disease.

One very important point: The association between alcohol and metabolic syndrome (pathophysiological mechanisms). Alcohol itself produces features of metabolic dysfunction

Attributable risk of the leading drivers of steatotic liver disease, including alcohol use, increased adiposity and obesity, diabetes, dyslipidemia, and arterial hypertension

Here we discuss:
-Importance of comprehensive history of alcohol use
-Impact of alcohol on metabolic syndrome criteria
-Longitudinal assessment of metabolic dysfunction and alcohol use
-Challenges in quantifying alcohol use
-Need for integrated approaches to manage MetALD

We are pleased to share our article Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease. Now available online in
@jhepatology.bsky.social
@MATHURINPHILIP1

#LiverSky #LiverSky authors.elsevier.com/a/1kOr5cOnAU...

Since we are in the Christmas spirit, Merry Christmas to all the researchers out there! #LiverSky

Seeing high MELD patients w/ ALD who re-compensate with sobriety & get their lives back (and avoid transplant!) is incredibly rewarding. As Hepatologists treating ALD, it is essential that we treat the underlying alcohol use disorder so our patients can improve! @juanpabloarab.bsky.social #liversky

There are *some* people whom steroids help

There is still value in trials, pragmatic trials, that refine inclusion criteria, dose, duration, and stopping rules

@anandvkulkarni.bsky.social
@juanpabloarab.bsky.social
@blaneymd.bsky.social

Don’t miss this December ENTIRE issue of HEPATOLOGY Journal dedicated to #ALD
Presented here by Dr. Michael R. Lucey @uwsmph
@AASLDtweets
Watch: buff.ly/41JYkRG

-Rare, but disulfiram is a notable exception🚨
-85% of cases attributed to Disulfiram
-Mortality or Transplant in 27% cases of Disulfiram-induced DILI.
-71% pts with severe or fatal disulfiram DILI had underlying liver disease

Can we please stop using Disulfiram in ALD?

🚨 ‼️Very Important Paper:
@HarishGMD et al.
📢 Drug induced liver injury from medications for alcohol use disorder

Key insights from US DILI Network @livertox @NIDDKgov @nagachalasani

pubmed.ncbi.nlm.nih.gov/39651750/

ALD and MASLD are a lot alike. How do we tell them apart on pathology?

Cindy Behling walks us through in this fantastic talk. 👏

#TLM24 #Liversky @juanpabloarab.bsky.social
#pathologysky

Happy to share our findings about naltrexone in decompensated cirrhosis, at #TLM2024.
Grateful for the support of my mentors Dr Devuni, @juanpabloarab.bsky.social, and my excellent co-author Dr Cooper! #LiverSky

Congrats to inspiring investigators @anandvkulkarni.bsky.social @juanpabloarab.bsky.social and team, for late breaking abstract about rapid taper of steroids in AAH at #TLM24
⤵️ infections, hospitalizations with rapid taper
💫 changing practice in management of AAH
#LiverSky #AASLD