IBDGC Genetics Consortium

‼️New publication‼️

Beecham et al. recently led an IBDGC study showing that higher African ancestry in a Hispanic IBD cohort is linked to greater risk of penetrating Crohn’s disease, perianal disease, and IBD‑related surgery, and identified ancestry‑specific genetic signals at key IBD loci.

‼️"Post-operative ileum transcriptomics implicate sex-biased mechanisms in Crohn’s disease recurrence" is now available online‼️
Click the link below to access the article on ScienceDirect!🔬🧬

authors.elsevier.com/a/1m7XV3mEmn...

Last month, the IBDGC met for the 2025 IBDGC Face-to-Face Meeting at the Broad Institute, coinciding with ASHG 2025. The meeting consisted of progress, future goals, & great discussions, focusing around analyses & data projects. Big thanks to Broad for hosting, & we're excited for next time we meet!

❕Save the date: Upcoming Event❕

Join Cedars Sinai's F. Widjaja Inflammatory Bowel Disease Institute for their 2025 IBD & Women's Health Conference!

🗓️ | Saturday, September 13, 2025
⏰ | 7:30 AM - 12:45 PM and 11:15 AM - 4:40 PM

Don't forget to register using the QR code on the attached flyer!

UPCOMING WEBINAR 📣
Join Dr. Francesca Luca (University of Chicago) for:
"Genetic and social factors in gene regulation and health" 🧬 🩺 💊

🗓️ June 26 | 🕐 1PM EST
💻 Free & Virtual
🔗 Register: mountsinai.zoom.us/webinar/regi...

‼️ NEW WEBINAR GOING LIVE THIS THURSDAY ‼️
Join Dr. Jimmie Ye (UCSF) for:
"Functionalizing Human Genetic Variation" 🧬🔬🧑‍🔬

🗓️ June 5 | 🕐 1PM EST
💻 Free & Virtual
🔗 Register: mountsinai.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: IBDGC Webinar Series: William Faubion. After registering, you will receive a confirmation email about joining the webinar. T Cell Therapeutics in Autoimmunity and IBD

📢 Happening TOMORROW!
Join Dr. William A. Faubion (Mayo Clinic) for:
"T Cell Therapeutics in Autoimmunity and IBD" 🧬🔥

🗓️ May 15 | 🕐 1PM EST
💻 Free & virtual
🔗 Register: shorturl.at/40xGs

#IBD #Tcells #GIresearch #Autoimmunity #Webinar #MayoClinic

🗓️ #DDW2025 Schedule – IBDGC Presentations

📍Posters

🧬 Sushma Maddipatla – scRNA-seq | Tues 5/20 (Poster Hall)
📸 Abhishek Dash – DL Imaging | Tues 5/20 (Poster Hall)

Stop by and chat IBD genetics with us!
#IBD #GIresearch #Crohns #Genomics #SingleCell #DDW25

🗓️ #DDW2025 Schedule – IBDGC Presentations

📍Oral Talks
🧬 Michelle Bao – PheWAS | Sat 5/17 @ 10:00am
🧬 Michelle Bao – Perturb-seq | Sun 5/18 @ 11:30am
🧪 Michiel Bak – Micronutrients | Mon 5/19 @ 9:15am
🌎 Ashley Beecham – Ancestry in U.S. Hispanics | Mon 5/19 @ 4:00pm

And don’t sleep on our IBDGC poster presentations at #DDW2025 👀🧬
📌
• S. Maddipatla (Emory) – scRNA-seq in Severe CD Across Ancestries
• A. Dash (Emory) – Deep Learning for Multiplexed Imaging

Let’s talk single-cell, segmentation & ancestry-driven discovery 💥
#IBD #SingleCell #Computational #DDW25

🚨 Headed to #DDW2025?
Catch the IBDGC team with high-impact oral presentations! 🔬🧬🎤
• M. Bao – PheWAS of Monogenic IBD Genes
• M. Bao – Perturb-seq in Monocytes
• M. Bak – Micronutrients & Recurrence
• A. Beecham – Ancestry in U.S. Hispanics
#IBD #GIresearch #Genomics #DDW25

🚨 Don’t miss this!
Dr. William A. Faubion (Mayo Clinic) will present:
"T Cell Therapeutics in Autoimmunity and IBD"
🗓️ May 15, 2025 | 🕐 1PM EST | 💻 Free + virtual

📌 Register: shorturl.at/40xGs
📄 Flyer: ibdgc.org
#IBD #GIresearch #Tcells #Autoimmunity #WebinarReminder

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis Objective Perianal Crohn’s disease (pCD) occurs in up to 40% of patients with CD and is associated with poor quality of life, limited treatment responses and poorly understood aetiology. We performed ...

🧬 What drives perianal Crohn’s disease?
Our study links a loss-of-function variant in CFB to increased pCD risk. This mutation disrupts complement cleavage + phagocytosis, revealing a new immune mechanism in pCD pathogenesis.
📖 Read more: gut.bmj.com/content/72/11/2068
#IBD #CrohnsDisease #Genetics

Curious where the data lives? 🧬💾
We keep it open, organized, and ready to explore at osf.ibdgc.org via the Open Science Framework!
Because science is better when it’s reproducible and shareable. 🧠🔍 #OpenScience #IBD #Genomics #Reproducibility

Inflammatory Bowel Diseases | Oxford Academic Inflammatory Bowel Diseases brings the most current information in clinical and basic sciences to physicians caring for patients with inflammatory bowel diseases, and investigators performing research in IBD and related fields.

New to this platform, but not new to asking big questions 🧬
Check out our deep dive: 11 Big Questions in IBD Genetics & Genomics—where a crew of experts tackles the biggest challenges in understanding Crohn’s and colitis at the molecular level.

📖 ibdjournal.org

#IBD #Genomics #GIresearch

New platform, same mission: figuring out if the sky is actually bluer—or just algorithmically different. 👀
If you're in the #IBD, #gdTcell, or #GIresearch world, help me reconnect! Would love to rebuild my research circles over here.