Miguel Soares

Biomedical Research We offer a multidisciplinary, transversal and integrated Master training from the bench to the bedside grounded on the four major areas of biomedical research: cell biology and cancer, neurosciences, ...

Applications are open for the Master in Biomedical Research (MIB)! Hands-on training at GIMM & FMUL. Cancer Biology, Neurosciences, Cardiovascular, Infection & Immunity. English-taught. Deadline: May 31. (@gimminstitute.bsky.social)
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medicina.ulisboa.pt/en/biomedical-research

This is the front cover of the new edition of @thelancet.com (thanks to @profstevegriffin.bsky.social for sharing) #HealthPolicy #Science 🧪🧵

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science Diverse voices overcome scientific challenges

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science | Science | AAAS www.science.org/content/arti...

The biggest science breakthroughs in 2025 From supercharged cancer cells to the first personalized gene-editing therapy, last year was full of scientific advances

The biggest science breakthroughs in 2025 | Science | AAAS www.science.org/content/arti...

@elmiguelche.bsky.social from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.

Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society.

Secure your ticket!
🔗 Get your ticket: fest.gimm.pt

🎟️ Early bird special rates

GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠

Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.

On the balance of knowledge Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...

The great Ruslan Medzhitov strikes again!

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

What a ride! 🎉

Congratulations to Madalena Pereira at the CAML-GIMM PhD Meeting 2026!
Fantastic work mapping brain circuits that orchestrate infection responses and halt sepsis progression 🧠🧬
@gimmfoundation.bsky.social

Congratulations to @soniatrikha.bsky.social at the CAML-GIMM PhD Meeting 2026!
Amazing work uncovering a molecular basis of how aging affects COVID-19 mortality 🧬
@gimmfoundation.bsky.social

Congratulations to @miguelmmesquita.bsky.social at the CAML-GIMM PhD Meeting 2026!
Incredible work revealing how macrophages protect themselves from death while engulfing red blood cells 🔴🧬
@gimmfoundation.bsky.social

From left to right: Sonia, Madalena and Miguel

Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬
The meeting showcased "home made" cutting-edge research!
Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social

Environmentally driven immune imprinting protects against allergy - Nature In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...

4/4: With @elisajentho
#DiseaseTolerance #EvolutionaryMedicine #AntagonisticPleiotropy
@gimmfoundation.bsky.social

3/4: This strengthens the evolutionary concept of antagonistic pleiotropy - the same genetic program that promotes survival early in life drives mortality later on.

2/4: Stress responses that enhance disease tolerance through tissue-damage control during reproductive years can impose lethal costs in post-reproductive life.

Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease t...

1/4:"Nothing in biology makes sense except in the light of evolution" - Dobzhansky
An intriguing discovery by the Ayres laboratory reveals how evolution shapes our response to infection across the lifespan. 🧬
Research: www.nature.com/articles/s41...

Ageing rewires the body’s tolerance to infection In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.

Ageing rewires the body’s tolerance to infection www.nature.com/articles/d41...

@gimmfoundation.bsky.social

With @elisajentho
#DiseaseTolerance #EvolutionaryMedicine #AntagonisticPleiotropy

This strengthens the evolutionary concept of antagonistic pleiotropy - the same genetic program that promotes survival early in life drives mortality later on.

Stress responses that enhance disease tolerance through tissue-damage control during reproductive years can impose lethal costs in post-reproductive life.

TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

Disinformation: When falsehoods become a political identity How storytelling is used as "investigation".

This is not an anomaly. It is a method.

Correction becomes harassment

Public discourse becomes “stalking”

Expertise becomes abuse

Evidence is replaced by narrative
Sex and victimhood are instrumentalised

Reputation damage is the objective

Klebsiella strain to protect against IBD gut infections A team of researchers led by Karina Xavier has uncovered a promising new live biotherapeutic agent that may redefine how the medical field approaches microbiota-based therapies.

New research led by @karinaxavierlab.bsky.social at 🇵🇹 @gimmfoundation.bsky.social demonstrates that a harmless strain of 🦠 #Klebsiella – discovered by chance in 🧫 laboratory experiments – can eliminate #infections and reduce gut inflammation in mouse models of inflammatory bowel disease. #IBD

10/10 Interested in this research? Contact us (miguel.soares@gimm.pt) for open positions & collaborations.
Mesquita, Figueiredo et al.
🔬 gimm.pt | gimm.pt/lab/miguel-s...
#malaria #bilirubin #immunology

9/10 🙏 Thanks @gimmfoundation.bsky.social, @miguelmmesquita.bsky.social for TWO knock-ins, Moisés Mallo for mouse genetics wizardry, Ana Nóvoa for golden hands, Ana Figueiredo for discovering bilirubin's antimalarial effect & support.

8/10 Could the antioxidant effects of bilirubin—first discovered by Dr. Roland Stocker—also protect the host and contribute to malaria protection beyond direct antiparasitic activity?