@labliston
Professor of Pathology at the University of Cambridge. Equalities Fellow, Welfare Tutor and Director-of-Studies at St Catharine's College. Educator, scientist, immunologist, daddy. Founder and CSO of Aila Biotech Ltd.
If you know a scientist who is struggling with self-doubt, please send them these stories.
"Simply realising that I am not alone has given me a profound sense of strength... reading your work has already helped more than I can express."
- Dr Nicola-Maria Riley
www.cam.ac.uk/stories/camb...
You can also read it online for free: heyzine.com/flip-book/a5...
Password: BeKind
Available on Amazon and Amazon Kindle:
www.amazon.co.uk/Self-Doubt-A...
Available from the Great British Bookshop (ships globally)
www.thegreatbritishbookshop.co.uk/products/sel...
If you know a scientist who is struggling with self-doubt, please send them these stories.
"Simply realising that I am not alone has given me a profound sense of strength... reading your work has already helped more than I can express."
- Dr Nicola-Maria Riley
www.cam.ac.uk/stories/camb...
Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27
Dogs and toddlers try to help adults. Cats only help if it is in their own best interests.
www.sciencedirect.com/science/arti...
Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field
www.annualreviews.org/content/jour...
Government instruction wasn’t especially clear or consistent
We also cover the increasingly promising attempts to exploit the properties of #tissueTregs in the clinic, and outline the key open questions for the field. We are really privileged to be tackling some of these questions in the lab right now, thanks to @erc.europa.eu and @wellcometrust.bsky.social.
If the authors are known to cut corners and fake data, I find that to be a relevant prism to view the paper through.
Likewise, if the authors are known to be experts in a method and publish work that is validated by others, I also find that relevant knowledge.
The molecular cues that induce the #tissueTreg phenotype are only partially understood, but key external signals from the tissue environment seem to be important in upregulating a core transcription factor set, which remodels the epigenetic and transcriptional landscape.
#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.
For all #Treg lovers, @labliston.bsky.social @annualreviews.bsky.social 👇👇👇 👉 doi.org/10.1146/annu...
It was a fascinating topic to write about, especially working with my knowledgeable coauthors Markus Feuerer, Daniel Gray, Lucille Rankin and Lisa Schmidleithner, based at @wehi-research.bsky.social / @unimelb.edu.au / University of Regensburg
www.annualreviews.org/content/jour...
We also cover the increasingly promising attempts to exploit the properties of #tissueTregs in the clinic, and outline the key open questions for the field. We are really privileged to be tackling some of these questions in the lab right now, thanks to @erc.europa.eu and @wellcometrust.bsky.social.
The cellular kinetics are not fully understood, however the majority of evidence using parabiosis, TCR retrogenics, cell transfers and fate-mappers suggest that the majority of #tissueTregs are pan-tissue, multi-tissue or tissue-cycling in their behaviour during homeostasis.
The molecular cues that induce the #tissueTreg phenotype are only partially understood, but key external signals from the tissue environment seem to be important in upregulating a core transcription factor set, which remodels the epigenetic and transcriptional landscape.
#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.
Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field
www.annualreviews.org/content/jour...
Once you have an offer in hand
Eventually they rebranded as the "Royal Humane Society", and switched to mouth-to-mouth resuscitation.
I'm not sure why the @royalhumanesociety.bsky.social history page glosses over this, I'd be leaning in to that backstory.
William Hawes and Thomas Cogan were so taken with the idea that in 1774, they formed "The Institution for Affording Immediate Relief to Persons Apparently Dead From Drowning", and set up bellows and enema pipes along the River Thames to rescue drowning victims by blowing smoke.
In 1746, a man revived his drowned wife by sticking his pipe into her rectum and blowing burning tobacco into her anus. As one does.
Things I learned today: the backstory to the @royalhumanesociety.bsky.social
Review @annualreviews.bsky.social Tissue Regulatory T Cells
www.annualreviews.org/content/jour... @labliston.bsky.social
Happy birthday to one of my favourite haters, Charles Darwin
Postdoc position on Asgard archaea in Thiago’s new lab for someone well trained in biochemistry, cloning, and protein purification:
international.au.dk/about/profil...