Kufer Lab , Department of Immunology

Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....

C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation NLRP10 is an atypical member of the NOD-like receptor (NLR) family because it lacks a leucine-rich repeat domain at its C-terminus. Recently, NLRP10 has been shown to form an inflammasome, however, th...

Our new manuscript describing the function of the basic c-terminal domain of NLRP10 is now available at Biorxiv.

www.biorxiv.org/content/10.1...

The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets - Nature Immunology Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.

Very nice review article on NLRP3 from Alex Weber et al. online!

The expanding role of the NLRP3
inflammasome from periodic fevers to
therapeutic targets

doi.org/10.1038/s415...

We are proud to present first data on our CAPE study at the #IUIS2025 in Vienna this week.
Come and discuss with us at Lucy’s poster
“Postprandial dynamic of immune cell responses and serum concentration of PRR ligands in humans”
Thursday, 21 August 2025, 12:15 - 13:45
Poster III.366

Warm invitation to the DGfI Autumn School! 💡 Deadline for application: July 31, 2025

The DGfI Autumn School invites you to embark on an up-to-date educational journey through the immune system.
dgfi.org/akademie-fue...

Registration: dgfi.org/akademie-fue...
Program: dgfi.org/wp-content/u...

Lucy's first paper on our RESIST PP project, describing a sensitive bioassay to measure NOD1/2 ligands in serum and differential postprandial NOD2 activation has been published!
Congratulations!
doi.org/10.3389/fnut...

Corona: Neue Variante NB.1.8.1, Impfung, Long Covid - Experte von der Charité klärt auf Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.

Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.

Out @natgenet.nature.com:

rdcu.be/eqGgf

Timo Voss from our group will present news on NLP10 at the #NCII in Tübingen.
Have a look at poster # P041

innate-immunity-conference.de

Next week the Novel Concepts in Innate Immunity Syposium in Tübingen starts!

Great line of Speakers put together by Alex Weber.

innate-immunity-conference.de

Cell-autonomous defense and innate immunity Cell-autonomous defense encompasses the inherent mechanisms of the cell that allow individual cells to protect themselves from infectious and inflammatory dangers. Recent advancements in the field in…

🗣️Our EMBO Lecture Course
"Cell-autonomous defense and innate immunity"
now is open for registration.
We are proud to present an excellent line of speakers!
Join us in India!
👇
meetings.embo.org/event/25-imm...

Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance - Nature Metabolism This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning.

Great Promethion-powered research from Anja Bosy-Westphal & colleagues @ Kiel University – “short-term consumption of protein-enriched UPFs did not prevent overeating but did favourably affect energy partitioning”! 🧪 www.nature.com/articles/s42...

Annual Meeting of our RESIST-PP consortium.

Having an intense and interesting meeting in Murcia, Spain.
Thanks to Pablo Pelegrin for perfect organization.

Rho GTPases emerge as more general regulators if NLR proteins. See news on Rac2 and Nlrp3.

Prof. Wagner and Team are developing nice games to teach immunology.
lnkd.in/e5AKif6w

Check it out: 😀👍
lnkd.in/eHPRakb7

#immunosky

With this #rothenfels2025 has come to an end🏁 Thanks to everyone who came and contributed with talks and discussions and fun and made it this special type of meeting🤩😎 Hope to CU again next year for #rothenfels2026 on March 16 to 18 - mark your calendars!📅
@dgfi-yi.bsky.social @dgfi-org.bsky.social

Dixon et al. identified ABHD17 enzymes as negative regulators of NOD2 that affect its membrane localization. 🔬
See my comment for details👇
doi.org/10.1016/j.jc...

🥳 We achieved our first Milestone with HDHL #Food4Health!

The main objective is to align R&I priorities among funding programmes by identifying research and policy needs to overcome the siloed approach between health & nutrition.
Interested in the specific objectives of this project?
bit.ly/3QOqX9Q

Santosh Chauhan and friends put together a great line of speakers for the
EMBO Conference "Cell-autonomous defense and innate immunity"🎤
3–5 December 2025 | IN-Hyderabad

More news coming soon... Stay tuned!
👇👇
coming-soon.embo.org/ielc25-02

Metagenomic estimation of dietary intake from human stool - Nature Metabolism Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.

What the sh*t did I eat?

"Metagenomic estimation of dietary intake from human stool"
Interesting news. Can we finally really say what I person eat?

www.nature.com/articles/s42...

And keynote speaker of day 2 Karsten Hiller of @tubraunschweig.bsky.social is giving us a deep dive into immuno metabolism in macrophages: #itaconate rules ✌🏻🤓 #Rothenfels2025

Timo Voss from our group presented news on NLRP10 at the Burg Rothenfels Meeting.
Very nice and interactive event! #DGfI

Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenito...

#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...

Dr Shouya Feng and Professor Seth Masters at their lab at Hudson Institute in Melbourne Australia

A rare & debilitating group of #AutoinflammatoryDiseases, Cryopyrin-associated periodic syndromes (CAPS), is closer to a cure thanks to a world first genetic analysis project. 🔥

Read more about Shouya Feng & Prof Seth Masters' study in journal Nature Immunology, or here: bit.ly/4ilMYsg

Frontiers | Editorial: Methods in molecular innate immunity: 2022 Advances in immunology are inherently linked to progress in implementing novel methods as best illustrated by the development of the cre-lox technique that a...

Nice Research Topic of "Methods in molecular innate immunity" now available at!
See our editorial👇👇👇
www.frontiersin.org/journals/imm...

It was great to meet the colleagues from the other projects!
Very nice interactive and informative day in Paris.
Thanks HDHL for the organization.

Last month, we organised the NUTRIMMUNE mid-term symposium, where six projects showcased their progress.

The symposium created the perfect space for researchers to connect🤝, exchange ideas💡, and foster new collaborations🌱.

Read more 👉 bit.ly/43KLdke

The Immune Alliance Lecture Series We welcome you to the next Immune Alliance Seminar, this time with Keishi Fujio (Tokyo) and Ulf Panzer (Hamburg). The lecture takes place on march 19, 2025, 9am (in Germany)/5pm (in Japan), via zoom. Everyone is welcome to join. Registration is free.

We welcome you to the next Immune Alliance Seminar, this time with Keishi Fujio (Tokyo) and Ulf Panzer (Hamburg).

The lecture takes place on march 19, 2025, 9am (in Germany)/5pm (in Japan), via zoom. Everyone is welcome to join. Registration is free.

Register via www.dgfi.org/immune-alliance/

#IUIS2025 is happening next year in Vienna, Austria, from August 17-22. Join us for a week of cutting-edge immunology, groundbreaking research, and global collaboration.
Early registration and abstract submissions are now OPEN at www.iuis2025.org! See you there! 🌍