PolyQuant GmbH

📣 💡 New publication employing our #QconCAT technology: 𝗙𝗚𝗙𝟭 𝗮𝗺𝗲𝗹𝗶𝗼𝗿𝗮𝘁𝗲𝘀 𝗵𝗲𝗽𝗮𝘁𝗶𝗰 𝘀𝘁𝗲𝗮𝘁𝗼𝘀𝗶𝘀 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗮𝗰𝘂𝘁𝗲 𝗮𝗰𝘁𝗶𝘃𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝘂𝗻𝗳𝗼𝗹𝗱𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝗮𝗻𝗱 𝗩𝗟𝗗𝗟 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻
pubmed.ncbi.nlm.nih.gov/41541501/

📢 We proudly announce the latest addition to our product portfolio. Our EcoCAT Kit provides 100 heavy isotope (15) labelled reference peptides for absolute protein quantification of 48 common and critical 𝘌. 𝘤𝘰𝘭𝘪-specific host cell proteins (HCP) using LC-MS/MS. www.polyquant.de/products/eco...

Looking for a sample preparation workflow for serum #proteomics? Drosos Katsavelis and colleagues compared six widely used workflows in terms of peptide yield, recovery, cost, sample preparation time and suitability for automation.
pubmed.ncbi.nlm.nih.gov/40857585/
#serumproteomics #massspectrometry

Our new whitepaper “Quantitative LC-MS/MS for Host Cell Protein Analysis in Biopharmaceutical Development and Production“ summarizes current best practices in #HCP analysis (methods, qualified standards etc) for monitoring host cell protein abundance.
www.polyquant.de/whitepaparer...
#proteomics

Publication alert: Mitochondrial proteomic adaptations to daily topor in the Djungarian hamster (Phodopus sungorus) pubmed.ncbi.nlm.nih.gov/40663131/. The authors quantified key proteins of the mitochondrial metabolism using #QconCATs from PolyQuant in the livers of Djungarian hamster.

Meet us at the 15th annual Oxford bacteriophage conference (01-02 September 2025 at St Edmund Hall, Oxford, UK) lpmhealthcare.com/phages-2025/.
We are happy to be given the chance to present our work and look forward to inspiring presentations, discussions and networking opportunities. #PhgOx25

🚨 Last chance!! ⌛Our introductory offer for our CHOcoCAT Kit will expire soon‼️
Only until 𝗝𝘂𝗹𝘆 𝟯𝟭𝘀𝘁, 𝟮𝟬𝟮𝟱 you can get reference standards for 𝗖𝗛𝗢-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗵𝗼𝘀𝘁 𝗰𝗲𝗹𝗹 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗱𝗲𝘁𝗲𝗰𝘁𝗶𝗼𝗻 and save -𝟱𝟬% of the regular price (MyFirstCHOcoCAT)
More information: polyquant.com/chococat polyquant.com/contact

New product! 📢 CHOcoCAT
A QconCAT Kit for absolute protein quantification of 29 common and critical CHO-specific host cell proteins (HCP) using LC-MS/MS.

Visit our website (lnkd.in/dyWUJrgA) for more information and save -50% 🎉 with the promo code "MyFirstCHOcoCAT" (until July 31st, 2025).

After one year of running smootly, we gave our #Orbitrap Exploris 240 a short break for its annual servicing procedure by #ThermoFisher. Big thanks to the maintenance engineer for his clear and instructive execution of the servicing procedure.🥇✨🌟
#MassSpectrometry #LCMSMS #Proteomics #TeamProteomics

20 years of #QconCATs! In our first newsletter of 2025 we dive into the history of QconCAT technology, highlight current #research and applications and offer a special discount on Calibration Standards and QconCAT Kits.
www.polyquant.de/_files/ugd/3...
#Proteomics #MassSpec #ProteinQuantification

The downside of remote work is that some of us do not meet very often. On the plus side: having everyone in the office at the same time is an occasion to celebrate! 🎉 Here we are enjoying a Bavarian "Weißwurst Frühstück" while connecting with colleagues, having inspring discussions and a great day!

Know your contaminant:
Ask us about our antibody-independent HCP (Host Cell Protein) analysis services for any production organism and even complex matrices.
✅ Analysis of the main protein (identity, purity, PTMs)
✅ Sensitive and unbiased HCP identification
✅ Absolute quantification of critical HCPs

5 years ago: Reichermeier et al., present a proteomics platform (PIKES), enabling them to study the dynamics of interchangeable multiprotein complexes by combining the #QconCAT technology with chemical freezing. pubmed.ncbi.nlm.nih.gov/31973889/.
#proteomics #massspectrometry #quantitativeproteomics

20 years of #QconCAT research highlight from February 2018:
“Stoichiometry, Absolute Abundance, and Localization of Proteins in the Bacillus cereus Spore Coat Insoluble Fraction Determined Using a QconCAT Approach“
pubmed.ncbi.nlm.nih.gov/29260567/
#massSpectrometry #proteomics #LC-MSMS

Publication alert 🚨: pubmed.ncbi.nlm.nih.gov/39884812/
#QconCAT-based targeted #proteomics to quantify the abundance of 6 transporters and 1 plasma protein marker in 5 placenta samples and associated cell lines and use of the data in a #PBPK model for IVIVE-based prediction of fetal drug exposure.

We proudly present a brand-new publication, applying our #QconCAT technology in #pharmacokinetic research:
“Transporter Expressions as Part of Required Scaling Factor to Support In vitro In vivo Extrapolation for Blood-Brain Barrier Drug Permeability” pubmed.ncbi.nlm.nih.gov/39826620/ #proteomics

Question to the #proteomics people #teamproteomics: FASP or GASP?
GASP may save you time but there seems to be a higher risk for missed cleavages. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... Any recommendations?

Quantify your #GFP-labeled proteins with our 15N-labeled GFP reference standard. Also for proteins that are difficult to quantify using #massspectrometry (few tryptic peptides, low signal intensity, etc.), GFP tagging may be the solution.
Need more information or a quote? www.polyquant.de/contact

This morning we noticed, that depending on the department, we seem to prefer special tea flavors.
Scientist: Ginkgo for a clear mind
Marketing: Heartwarming

Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides - PubMed Absolute quantification in proteomics usually involves simultaneous determination of representative proteolytic peptides and stable isotope-labeled analogs. The principal limitation to widespread impl...

Congratulations on 20 years of #QconCAT technology! We are always happy to read #proteomics research articles employing our QconCATs. Throughout 2025 we will present our favourite articles, starting with the original publication.
Stay tuned for more research highlights, applications and promotions.

Our fourth quarterly Newsletter is officially online. As usual, we summarize research publications employing our #QconCAT technology. Have a look: www.polyquant.de/_files/ugd/3.... And watch out for 2025 as we will celebrate the 20th birthday of QconCATs with special editions, promotions etc.🎂🎉🥳

Creation, Lessons, Love, Mud 🤔

We will go on a (well deserved 😉) Christmas break (23.12.2024-6.1.2025). During that time processing of your requests can take a little longer. We will be back in full swing on January 7,2025.

Do you want to know why we love metabolic 15N labeling for absolute protein quantification? Have a look at our latest poster, presented at this year's HUPO in Dresden. lmy.de/cpwtE

#QconCAT #SIL #SILAC #stableisotopelabeling #massspectrometry #referencestandard

With Christmas approaching, we are offering our QconCATs, Calibration Standards and QconCAT Kits at special prices. Contact us to benefit from our time-limited offer and receive high quality products at lowest prices. #QconCAT #proteomics #LCMSMS #peptides #referencestandards