OHSU-MMI

A warm welcome to our new Department chair, Fikadu Tafesse @tafesselab.bsky.social !!

Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...

Congratulations to the Rauch lab @rauchlab.bsky.social on their newest publication!

A group foto of the MMI department at the 2025 retreat

Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.

Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!

🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...

#blackinImmuno #BlackinMicro #Sacnas

Trump’s Cuts Are Making Federal Data Disappear Online tools that professionals use for everything from diagnosing diseases to calculating insurance payouts are going dark.

The Trump admin is erasing critical federal data - including climate trends, water quality, wildfire risk, public health stats, and pollution monitoring.

When the data goes dark, the American lives are at risk.

This is how To Sabatoge A Nation👇


zurl.co/slECM

Congratulations to Bahareh Ajami and her lab @baharehajami.bsky.social ! Dr. Ajami and her team of 6 are studying one of the most promising theories in ALS immunology today. alsnorthwest.org/research-app...

Congratulations to @tafesselab.bsky.social for promotion to Full Professor with tenure!!! Well deserved!

Check out the mucosal Immunology podcast episode with MMI faculty member @rauchlab.bsky.social

Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...

It’s finally out!

Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊

Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social

pubmed.ncbi.nlm.nih.gov/40473211/

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Congratulations to the Tafesse lab on their recent publication on the effects on timing in repeat vaccinations!

Analysis of Factors That Regulate HIV-1 Fusion in Reverse Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...

Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...

kermit the frog from the muppet show is standing in front of a red curtain . ALT: kermit the frog from the muppet show is standing in front of a red curtain .

Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...

Cuts to science research funding cut American lives short − federal support is essential for medical breakthroughs The National Institutes of Health has been integral to scientific progress in treating countless human diseases. Without its support, patients will ultimately pay the price.

Federal funding of biomedical research has been a remarkably successful partnership, with benefits that are so intertwined in our daily lives that they can be easy to take for granted.

So what will we lose if the U.S. continues to defund research?

theconversation.com/cuts-to-scie...

Thank you to Adair Borges @adairb.bsky.social for giving a great talk about her exciting science at @arcadiascience.com and for discussing careers in biotech with our trainees!

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs:
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".

www.embopress.org/doi/full/10....

New publication out of the @rauchlab.bsky.social at OHSU MMI

Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal "These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...

It was signed by over 450 OHSU researchers!

It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

Come join us! No excuses!!!

NIH funding freeze stalls applications on $1.5 billion in medical research funds The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.

NIH funding freeze stalls $1.5 billion in medical research grant funding : Shots - Health News www.npr.org/sections/sho...

A flyer for the “stand up for science” event March 7, 2025, at the Oregon capitol (Salem)

Join me in standing up for science on March 7. in Salem, Oregon!
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org

Congratulations Ankit!!

@laurenrodda.bsky.social and her trainee @georgecelis.bsky.social from our department, together with @joshuamoreau.bsky.social , Rashi Yadav and Abrar Samiea from @ohsuknight.bsky.social wrote a review on B-cells, check it out!

If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky

A big thank you to Kelsey Sivick, our invited seminar speaker from Arcus biosciences, for giving a riveting talk about the development of a TIGIT inhibitor and educating our trainees on careers in biotech!

Congratulations to the newly minted Dr. Huber, who successfully defended their thesis on MR1 regulation, done in the Harriff lab, last Friday!!

Could you add us please ? 🤚

Hi, thanks for making this list! Can we get added?