PhD programs worldwide face an urgent question: How should trainees use ChatGPT, Claude & similar tools?

Now online: two resources on thoughtfully integrating generative AI into research training.

📄 Conceptual framework: zenodo.org/records/18649847
📋 Practical guide: zenodo.org/records/18452319

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Proud to see such progress from our lab, and looking forward to how the community will use GUANACO in their own research. 3/

Having witnessed Chloe’s dedication and hard work firsthand, it’s inspiring to see GUANACO come to life so quickly. The tool makes data exploration more intuitive, customizable, and collaborative — lowering technical barriers and letting researchers focus on biology. 2/

GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization While single-cell multi-omics has advanced our understanding of cellular heterogeneity, the complexity of these datasets remains a barrier for non-computational users. Here, we introduce GUANACO, a Da...

Happy to see the release of **GUANACO** — a new Python package for interactive multi-omics single-cell data exploration and sharing, now available on bioRxiv: www.biorxiv.org/content/10.1...

Also, many in the medical profession now try to discourage the military metaphor, and for good reason.

Diane, I wrote a lecture by talking about it Posted on Thursday 20 Mar 2025. 831 words, 8 links. By Matt Webb.

I blogged about how I use transcription + a fake persona called Diane (from Twin Peaks) to write talks and blog posts etc, just by talking to my Apple Watch

The persona means I can make adjustments while I talk: uh Diane put that last para in the previous section

interconnected.org/home/2025/03...

Teaching Claude To Teach Claude To Play Chess When AI competes against a powerful chess engine, it seems doomed - unless the AI learns how to cheat.

To experiment with multi-agent systems you either need a clear business case and big budget, or you need to be a jabroni with a high credit limit.

I'm just the jabroni for the job, so I taught Claude to play chess, and learned a ton along the way:
jfkirk.github.io/posts/claude...

Was asked to contribute brief commentary about my views on the present and future of AI models for regulatory genomics. Wud love for others to add their comments to this thread.

Also check out commentaries from @jianma.bsky.social, Katie Pollard, Remo Rohs & others

www.cell.com/molecular-ce...

Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...

Effects of Acute PM2.5 Purification on Cognitive Function and Underlying Mechanisms: Evidence from Integrating Alternative Splicing into Multi-Omics
www.sciencedirect.com/science/arti...

Dr. Yang Li’s team at the University of Chicago revealed that alternative splicing is not just about creating protein isoforms—it also critically controls gene expression levels. This discovery shifts our understanding of RNA processing and its influence on cellular biology.

hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer known for its high rate of early metastasis, necessitating the discovery of the underlying …

hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma 🧪 #PancreaticCancer www.sciencedirect.com/science/arti...

Coordinated alternative splicing decisions via stepwise exon definition https://www.biorxiv.org/content/10.1101/2024.12.18.629257v1

The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look!
A thread 🧵

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...

The landscape of expression and alternative splicing variation across human traits García-Pérez et al. perform a multi-tissue analysis of the association between demographic and clinical traits and human transcriptome variation. Ancestry, sex, age, and BMI and certain diseases make ...

The landscape of expression and alternative splicing variation across human traits

www.cell.com/cell-genomic...

Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies https://www.medrxiv.org/content/10.1101/2024.11.25.24317569v1 Breast cancer is a heterogeneous disease that can be molecularly classified based on the expression

Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies https://www.medrxiv.org/content/10.1101/2024.11.25.24317569v1