ASBMB Journals

We are pleased to present a curated collection of cutting-edge research articles in the Journal of Biological Chemistry, highlighting innovative discoveries and emerging advances in cancer cell signaling and metabolism.
www.jbc.org/jbc-canc...
#jbiolchem

This is a Journal of Lipid Research symposium!
#JLipidRes #MakeItPossible

This is a Journal of Biological Chemistry symposium! #JBiolChem #MakeItPossible

2026 ASBMB Annual Meeting flyer promoting a symposium on biochemical modifications in health and disease with four session speakers listed.

#ASBMB26 symposium | March 8

"Biochemical modifications in health & disease" will explore the latest insights into how biochemical modifications shape physiology & pathology.
www.asbmb.org/annual-meeti...

🎤 @irinabezsonova.bsky.social, Robert Haltiwanger, Paul Shapiro & @brianstrahl.bsky.social

We are organizing a mini-symposium on "Membrane and Organelle Dynamics" at ASBMB 2026! #ASBMB @asbmb.bsky.social
@aydinlab.bsky.social and I have put together a fantastic lineup of speakers for Day 1 morning. Come learn about some cutting-edge research in the field.

Allosteric targeting with antiviral nucleotide analogues allows fine-tuning of SAMHD1 dNTPase activity SAMHD1 is a deoxyribonucleoside triphosphate (dNTP) hydrolase that controls intracellular dNTP pools and plays diverse roles in human health and disease. Notably, this enzymatic activity also confers ...

Excited to share the latest research from the group!

We have a new paper out in @asbmbjournals.bsky.social led by our first PhD student!

Here we look at the enzyme SAMHD1, a key player in dNTP metabolism and chemotherapy resistance

www.jbc.org/article/S002...

cc @scilifelab.se @ki.se

🧵

Figure 2. G-protein signalling mechanisms of Albumin-S1P, FTY-720 and ApoM-HDL-S1P

New in JBC press| Apolipoprotein M: Structural Insights, Functional Roles and Therapeutic Approaches in Vascular Disease.
Learn more:
www.jbc.org/article/...
#asbmbJBC

Building better tools to decipher the lipidome Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.

Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spec tools for studying complex lipid systems.
www.asbmb.org/asbmb-... #JLipidRes

Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.

🌍 Join #MolCellProt in celebrating the International Day of Women and Girls in Science!

Women in Proteomics, a new MCP special issue, showcases women driving innovation and discovery in proteome research.

➡️ Read more: www.mcponline.org/wo...
🎨 Luciana Giono

Figure 7. Development of a combinatorial exo-protein diagnostic biomarker panel and assessment of MUC1 exo-protein in plasma-derived EVs.

New in MCP Press| Circulating extracellular vesicle protein biomarkers for the early detection of high-grade serous ovarian cancer.
Learn more:
www.mcponline.org/ar...
#molcellprot

Antibody array-based proteomic screening of colorectal cancer stool and graphical representation of significantly different proteins in CRC vs HC.

#WorldCancerDay research spotlight: "High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen" by Vanarsa, Kamala et al.

➡️Access the #MolCellProt paper: www.mcponline.org/ar...

Molecular modelling of TAM+M interaction with hBKCa.

#WorldCancerDay research spotlight: Tamoxifen metabolites acting via BKCa orchestrate the dynamics of K+ and Ca2+ in breast cancer cells by Maier, Selina et al.

➡️Access the #JBiolChem paper: www.jbc.org/article/...

Scientists identify pan-cancer biomarkers Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies. Read about this recent article published in Molecular & Cellular Proteomics.

#WorldCancerDay | Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies.

➡️ Read about this recent article published in Molecular & Cellular Proteomics: www.asbmb.org/asbmb-...
#MolCellProt

Matrix metalloproteinase inhibitor reduces cancer invasion Scientists at the Mayo Clinic engineered a TIMP-1 protein variant that selectively inhibits MMP-9 and reduces invasion of triple-negative breast cancer cells, offering a promising tool for targeted ca...

On #WorldCancerDay, ASBMB highlights research driving more precise cancer therapies.

In #JBiolChem, Mayo Clinic researchers engineered a TIMP-1 protein variant that selectively inhibits MMP-9 & reduces invasion of triple-negative breast cancer cells.
www.asbmb.org/asbmb-today/...

New in JBC press| Tamoxifen metabolites acting via BKCa orchestrate the dynamics of K+ and Ca2+ in breast cancer cells.
Learn more:
www.jbc.org/article/...
#jbiolchem

Very happy that our work on the T6SS ADP-ribosylcyclase toxin made the Cover at JBC @asbmb.bsky.social y.social ! Congratulations Julius @jmartinkus.bsky.social for designing this Cover !
@dukasju.bsky.social @laurentterradot.bsky.social

A new family of TonB-dependent copper transporters linked to respiratory oxidase function Copper is an essential metal notably found in respiration complexes for its redox properties. It is also toxic hence its cellular trafficking is tightly controlled. Bacteria have developed a number of...

📢 A new pub in J. of Biological Chemistry @asbmbjournals.bsky.social by Dr Françoise Jacob-Dubuisson team

“A new family of TonB-dependent copper transporters linked to respiratory oxidase function"

@inserm.fr @cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @rechercheulille.bsky.social

Cantu syndrome–associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels Gain-of-function (GOF) mutations in either Kir6.1 (encoded by KCNJ8) or SUR2 (encoded by ABCC9) are causally associated with Cantu syndrome (CS), characterized by coarse facial appearance, hypertricho...

The Cantu-syndrom H60Y mutation in the SUR2 subunit of ATP-sensitive potassium channels results in gain of function only when paired with Kir6.1. New Dynaflow publication in Journal of Biological Chemistry.

👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels

Figure 3. Mice with adipose-specific deletion of CSN8 display insulin resistance and altered energy homeostasis.

New JLR press| Scientists' data highlights that CSN8/CSN is crucial for maintaining protein homeostasis in adipose tissue.
Learn more:
www.jlr.org/article/...
#jlipidres

Figure 1. Structural overview of NMDARs. (A) Domain architecture of GluN1. Amino acid sequence of the CaM binding site in GluN1-C0 is indicated in the box. (B) Multiple sequence alignment of human GluN1-C0 with the IQ motif of human CaV1.1 and CaV1.2, and the CaM binding site in the human olfactory cyclic-nucleotide gated channel, CNGA2.

New in JBC press| Structural Basis and Functional Analysis of NMDA Receptor Regulation by Calmodulin.
Learn more:
www.jbc.org/article/...
#jbiolchem

Figure 1. Single-cell RNA-seq identifies BASP1 expression is elevated in chemoresistant OSCC.

New in JBC press| Scientists' study demonstrates that BASP1 acts as a key regulator of EMT in cisplatin-resistant oral squamous cell carcinomas.
Learn more:
www.jbc.org/article/...
#jbiolchem

Figure 2. CSF survey PRM assays developed from either Stellar MS linear ion trap (LIT) GPF library or Orbitrap™ (OT) GPF library data.

New in MCP press| Scientists observe that proteins selected based on their measurement robustness are still able to capture differences in abundance across disease groups in a small sample set.
Learn more:
www.mcponline.org/ar...
#molcellprot

Figure 3. Assessment of macrophage beta oxidation and fatty acid synthesis in sham and CKD mice.

New in JLR press| Chronic Kidney Disease Induces Distinct Alterations of Macrophage Lipid Metabolism in a Mouse Model of Atherosclerosis.
Learn more:
www.jlr.org/article/...
#jlipidres

This JBC cover image depicts HDAC7 (colored protein) bound on chromatin in complex with Histone H3.3.

This #JBiolChem cover depicts HDAC7 (colored protein) bound on chromatin in complex with Histone H3.3.

➡️ Details: Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells by Hassan et al.
www.jbc.org/article/S002...

Modanovo: A Unified Model for Post-Translational Modification-Aware de Novo Sequencing Using Experimental Spectra from In Vivo and Synthetic Peptides Post-translational modifications (PTMs) play a central role in cellular regulation and are implicated in numerous diseases. Database searching remains the standard for identifying modified peptides fr...

Modanovo: A Unified Model for Post-Translational Modification-Aware de Novo Sequencing Using Experimental Spectra from In Vivo and Synthetic Peptides - Molecular & Cellular Proteomics www.mcponline.org/article/S153...

The effect of PEGylation on surface tethering of liposomes via DNA nanotechnology. Polyethylene glycol (PEG) is widely used in liposome formulation due to its blocking properties and ability to prolong circulation in vivo, to create biomimetic liposomes and drug delivery devices. Si...

Our work led by PhD student James Gaston is out online at Journal of Lipid Research.

We looked at how % PEG3000 affected the size and stickiness of liposomes, to work out best conditions for combining DNA and lipid nanotechnology.

@unswbabs.bsky.social

www.jlr.org/article/S002...

Conserved early steps of stemmadenine biosynthesis Stemmadenine acetate is a pivotal intermediate in the production of pharmacologically active monoterpene indole alkaloids. Here, we identify orthologs of stemmadenine acetate pathway genes (SGD, GS, G...

Conserved early steps of stemmadenine biosynthesis - Journal of Biological Chemistry www.jbc.org/article/S002...

Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes Genomic instability and loss of proteostasis are two of the primary Hallmarks of Aging. Although these hallmarks are well-defined in the literature, the mechanisms that drive genomic instability and l...

Inside #JBiolChem: Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes by Power, Lindsey N. et al.
www.jbc.org/article/S002...

A graphic announcing that the Promoting Research Opportunities for Latin American Biochemists program is accepting applications and that the deadline to apply is March 20.

🌎 Take your research abroad with PROLAB!

Promoting Research Opportunities for Latin American Biochemists offers grad students and postdocs the opportunity to spend up to six months in labs in the U.S. or Canada.

➡️Up to $7,000 | Apply by March 20
www.asbmb.org/awards...

A NYE countdown, rendered in 3D!

➡️ Learn more about cutting-edge protein research at #ASBMB26: www.asbmb.org/annual-meeti....

🎨 Structures from @rcsbpdb.bsky.social
#HappyNewYear #Biochemistry #MolecularBiology #MakeItPossible