Kevin Monahan

Another fantastic day at #InSiGHT2026 🔬

Day 3 highlighted major progress in hereditary GI cancers: From gastric & #PancreaticCancer updates to key advances in #LynchSyndrome. Great talks, global insights, and an excellent panel discussion.

#GICancerPrevention #MedicalResearch

✨ We were truly privileged to welcome Dr Poh-Koon Koh, Senior Minister of State for Health and Manpower, Singapore, as our Guest of Honour on Day 4 of #InSiGHT2026.

It was an inspiring session followed by meaningful discussions. 👏

#GuestOfHonour #AdvancingGIcancerResearch

That’s a wrap on #InSiGHT2026! A huge thank you to our scientific committee, organisers, speakers, participants, sponsors & partners for driving an incredible exchange of ideas. Your commitment to advancing research and care in hereditary GI cancer makes all the difference. 🌟

#InSiGHTcommunity

Our Young InSiGHT members are off to a strong start of #InSiGHT2026!
Day 1 - Padel session full of energy & teamwork
Day 2 - Breakfast session with great conversations & new connections
And this is only the beginning! We can't wait to see this #InSiGHTCommunity grow 🌟

#GIcancer #YoungInSiGHT

Ready for Day 3 of #InSiGHT2026 ?👀

Don’t miss these exciting sessions:

🧬Session 7: Hereditary Gastric Cancer Surveillance and Management
🔬Session 8: Advances in Pancreatic Cancer Research
🧪Sessions 9 & 10: Advances in Lynch Syndrome Research

#InSiGHTCommunity #GIcancer #LynchSyndrome

Improving care for Lynch syndrome patients: integrating surveillance into England’s national bowel cancer screening programme

link.springer.com/article/10.1...

COLO-REACH UK = the new name for the EOCRC Research Consortium (REsearch in Early Age Colorectal cancer Hub) supporting collaboration between UK clinical academics and patients in research of bowel cancer in people below age 50 years @bowelcanceruk.bsky.social

Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD:
jobs.icr.ac.uk/vacancies/14...

It's bench-to-bedside research, translating biology of pre-cancer evolution.

Funded by @bowelcanceruk.bsky.social

Outcomes from the English National Lynch Syndrome transformation project The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation P...

Outcomes from the English National #LynchSyndrome transformation project: New diagnoses of LS have consistently increased each year from a total of 545 in 2020 to a total of 1394 in 2024 (an increase of 255% vs. a target of >50%).

onlinelibrary.wiley.com/doi/10.1002/...

Century-old tumours could reveal why more young people are getting bowel cancer - BBC News Bowel cancer in people under the age of 50 is increasing worldwide and scientists are striving to find out why.

Read about our plans to analyse the century long archive at St Mark's Hospital to understand why more young people are being diagnosed with bowel cancer @trevorgraham.bsky.social

www-bbc-co-uk.cdn.ampproject.org/c/s/www.bbc....

We’re proud to present the current Council members of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), driving progress in research, collaboration, and patient care worldwide.

Learn more about us👉 shorturl.at/6cyJV

#Genetics #GIHealth #HereditaryGICancer #InSiGHT

Diagnostic yield of colonoscopy in Lynch Syndrome

We demonstrate a high adenoma burden with distinct phenotypic and gene-specific characteristics in a UK LS population undergoing high quality surveillance

fg.bmj.com/content/earl...

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

We are looking for our new Tom Smith Clinical Research Fellow in #LynchSyndrome and Early Onset ColorectalCancer with @trevorgraham.bsky.social in translational science … thanks to 40tude curing colon cancer for supporting this fellowship - get in touch! @stmarksgenomics.bsky.social @icr.ac.uk

We had the 3rd meeting of the UK EOCRC Research Consortium in beautiful Edinburgh yesterday supported by British Society of Gastroenterology (BSG) and @bowelcanceruk.bsky.social attended by over 50 UK academics - celebrating our first project funding success only 1 year after foundation

James D Watson, co-discoverer of the structure of DNA, dies aged 97 Remembered for breakthrough with Francis Crick, Watson was later ostracised by the scientific establishment over comments on race

James D Watson, co-discoverer of the structure of DNA, dies aged 97

Low Yield of Genetic Testing in Serrated Polyposis Syndrome

journals.lww.com/ctg/fulltext...

And they’re off! 🏁 👟

Elaine Burns🚶‍♀️Vs Danilo Miskovic 🏃

Our colon cancer workshop is on day 2 of ‘Frontiers’ - run or walk with our experts 🌟

(Must watch video below 👇🏻😜)

Sign up to be in with a chance to participate - bit.ly/4ktsvDc

@lnwh.bsky.social
@kevinmonahan.bsky.social

'Everybody's unique in their own way' - Tadej Pogačar plays down greatness after record-breaking fifth consecutive Il Lombardia victory Pogačar dedicates his victory to teammate Rafał Majka

'Everybody's unique in their own way' - Tadej Pogačar
Love this guy - The true #GOAT
www.cyclingnews.com/news/everybo...

DNA mutagenesis driven by transcription factor competition with mismatch repair Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

Can we prevent IBD?

We are delighted to have Prof. Johan Burisch as one of our visiting professors for this years Frontiers congress 🙌🏻

Hear more about Prof. Burisch in the video below ⬇️

Register now - bit.ly/4ktsvDc

@lnwh.bsky.social
@kevinmonahan.bsky.social

Final Call for Abstracts – Deadline Today!⏳

Don't miss your chance to be part of the #InSiGHT2026 Biennial Meeting in #Singapore! 🌏

🗓️ Submission Deadline: 30 September 2025
⏰ Time: Midnight (Singapore Time) / 6pm CET

Submit your abstract now! insight2026.org/abstract-sub...

#Genetics #GIcancer

🚨 Final Call: Abstract submissions for #InSiGHT2026 close TOMORROW – Sept 30!

Join the global conversation on hereditary GI tumours.
Submit now 👉 insight2026.org

Let your research drive progress.

#MedicalResearch #Genetics #GIcancer #AbstractSubmission

Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history

onlinelibrary.wiley.com/doi/10.1002/...

Low Yield of Genetic Testing in Serrated Polyposis Syndrome - PubMed Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing appears to have...

Genetic testing appears to have limited utility in SPS patients and may primarily identify those with an incidental diagnosis of Lynch syndrome

pubmed.ncbi.nlm.nih.gov/41002021/

Fluctuating DNA methylation tracks cancer evolution at clinical scale Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc

Epigenetic clues from cancer’s past foretell its future An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

Lineage tracking using methylation states from longitudinal bulk sampling. Sounds 🆒 and given recent work by @trevorgraham.bsky.social and colleagues, looks real.

Wondering about other applications like 🦠🧫

👉🏻News and views: www.nature.com/articles/d41...
👉🏻Paper
www.nature.com/articles/s41...

🚨 It’s here!
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines

#InSiGHT2026 #HereditaryCancer #GICancerResearch

🚀 Exciting news! We’re launching Young-Insight for InSiGHT members under 40.
Join our first meeting to share ideas & shape the future of our community. Email admin@insight-group.org with subject “Young Insight” to get involved! 🌍✨ #InSiGHT

Comparative insight: hereditary colorectal cancer registries in Iran, Singapore, and South Africa - Familial Cancer This study compares three hereditary colorectal cancer (CRC) registries—the Iranian Hereditary Colorectal Cancer Registry (IHCCR), the Singapore Polyposis Registry (SPR), and the University of Cape To...

The registries’ combined experiences underscore the critical need for integrated, culturally sensitive strategies combining genetic testing, enhanced surveillance, and family-based management to improve outcomes #Polyposis #LynchSyndrome

link.springer.com/article/10.1...