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Aguirre-Ghiso Lab

@jaguirreghisolab

We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent and treat metastasis. https://einsteinmed.edu/faculty/16974/julio-aguirre-ghiso

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22.01.2025
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Latest posts by Aguirre-Ghiso Lab @jaguirreghisolab

A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential - Nature Communications PRRX1 is an epithelial– mesenchymal transition-linked transcription factor. Here, the authors discover that intermediate PRRX1 levels primes cancer cell for high invasion and metastatic fitness, where...

www.nature.com/articles/s41...

09.03.2026 13:41 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Super excited to visit NYU Cancer Center tomorrow, and catch up with friends and colleagues sharing our most recent work @cdi-einstein.bsky.social. See you!

03.03.2026 23:34 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Check out our new preprint on how galectin-1 function is hijacked to fuel early dissemination & metastatic onset in breast cancer. Huge congrats to Ramiro Perrotta, Luis Valencia Salazar, the entire team, and to the amazing Mariana Salatino & Gabriel Rabinovich! www.biorxiv.org/content/10.6...

26.02.2026 16:07 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

You know when someone is not up for the task. It's OK not everyone can do everything. Unfortunately, our country depends on it.

04.02.2026 17:43 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis - Nature Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...

www.nature.com/articles/s41...

04.02.2026 17:40 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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More than one-third of cancer cases are preventable, massive study finds Many cancers are linked to two modifiable habits: tobacco smoking and alcohol consumption.

www.nature.com/articles/d41...

04.02.2026 02:05 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial - Nature Medicine In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (befor...

www.nature.com/articles/s41...

04.02.2026 02:03 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Neoadjuvant ipilimumab plus nivolumab in melanoma: 5-year survival and biomarker analysis from the phase 2 PRADO-trial - Nature Medicine Five-year survival data and biomarker analysis of the PRADO extension cohort of the phase 2 OpACIN-neo trial, in which patients with high-risk stage III melanoma received neoadjuvant ipilimumab and ni...

www.nature.com/articles/s41...

02.02.2026 01:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Cell stiffness regulates immune evasion during metastatic dormancy - Nature Cancer Dormant metastases can lead to tumor relapse after many years by successfully escaping immune surveillance. A new study identifies an atypical epithelial-to-mesenchymal transition state that presents ...

www.nature.com/articles/s43...

01.02.2026 17:02 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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A β€˜time capsule for cells’ stores the secret experiences of their past Scientists have transformed enigmatic cell structures, called vaults, into storage units for messenger-RNA molecules made in the past.

A β€˜time capsule for cells’ stores the secret experiences of their past www.nature.com/articles/d41...

16.01.2026 14:54 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Support the Empire Biomedical Research Institute (EBRI) Tell New York Governor Hochul and your state legislators to support including the Empire Biomedical Research Institute in the 2027 Executive Budget. This is an urgent matter relating to funding life-s...

actionnetwork.org/letters/supp...

10.01.2026 16:09 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why cancer can come back years later β€” and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Important to see the acknowledgement of cancer dormancy & that top journals continue to highlight & publish on this topic. This problem is now studied in major Institutions worldwide. Congrats to all who work in this space! It is making & will make a difference! www.nature.com/articles/d41...

06.01.2026 21:12 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Important for @einsteinmededu.bsky.social to be part of this initiative!

02.01.2026 23:43 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Support a New York State Biomedical Institute for a Healthier, More Affordable Future Can you spare a minute to help this campaign?

c.org/2f2VMzPJbb

02.01.2026 23:37 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Happy new year to all! Thanks to my lab, colleagues and collaborators that made 2025 a great year despite all the challenges!

02.01.2026 14:49 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Great pic of Lucia Petriz-OtaΓ±o receiving her MSc degree from Albert Einstein College of Medicine with Anna Adam-Artigues, PhDand Unai Heras Manterola. Good things to remember - experiencing great science in πŸ‡ΊπŸ‡Έ- let’s keep it going!

13.12.2025 15:09 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Wonderful end of year celebration and secret Santa at the @jaguirreghisolab.bsky.social lab! Thanks all for a wonderful year!

06.12.2025 20:45 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Eight millennia of continuity of a previously unknown lineage in Argentina - Nature A previously unsampled deep lineage in central Argentina was discovered that had distinctive genetic drift by 8,500 bp and persisted as the main Native American ancestry component in the reg...

Fascinating !
www.nature.com/articles/s41...

27.11.2025 01:01 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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CΓ‘ncer de piel: ya estΓ‘ disponible la vacuna argentina para tratar el melanoma de alto riesgo Es la primera que se aprueba en su tipo para etapas mΓ‘s tempranas; es para uso en centros especializados y con supervisiΓ³n mΓ©dica

www.lanacion.com.ar/sociedad/can...

24.11.2025 17:06 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

My mum says β€œyou never get over not knowing where your next meal is coming from” πŸ™

23.11.2025 22:19 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

πŸ“’ SIGN & SHARE THE PETITION! πŸ“’

New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

24.11.2025 15:52 πŸ‘ 37 πŸ” 39 πŸ’¬ 1 πŸ“Œ 10

EBRI will power the full pipeline β€” from foundational discovery to drug development β€” and support education, technology & clinical trials.

Momentum matters. Broad public support will help make this real.

We all have a hinterland β€” time to gather your troops!

✍️ Please sign and tell 10 to tell 10…

24.11.2025 15:57 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Congrats!

20.11.2025 02:18 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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What a pleasure to have hosted Dr. Joan Massague from MSKCC @mskcancercenter.bsky.social who visited us all day and delivered an exceptional lecture for our @einsteinmededu.bsky.social Montefiore Einstein Comprehensive Cancer Center distinguished lecture series. Thanks for visiting!

14.11.2025 00:42 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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We wrapped the @cdi-einstein.bsky.social Retreat with four impressive projects from our workshop by Unai Heras Manterola, Lindsay Lafave, Maria Sosa, and Kamini Singhβ€”covered dormancy & bioengineering, neoantigens, transcriptional heterogeneity & lung cancer. Wow! Thanks to all who participated!

07.11.2025 18:43 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Exciting to wrap up the presentations at our CDI retreat with two phenomenal talks by @cdi-einstein.bsky.social latest recruits who will start in 2026 @swagatag.bsky.social from @mit.edu and @samhegde.bsky.social from @mountsinainyc.bsky.social welcome to @einsteinmededu.bsky.social

07.11.2025 15:20 πŸ‘ 6 πŸ” 1 πŸ’¬ 2 πŸ“Œ 1
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Today we had a phenomenal first day of our @cdi-einstein.bsky.social retreat. Great talks by @soledadsosalab.bsky.social Anna Skwarska and John McAuliffe.

07.11.2025 01:08 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Thanks !

06.11.2025 18:28 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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And now David Entenberg presenting on mechanism of lung colonization

06.11.2025 15:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Now Wenjun Guo @cdi-einstein.bsky.social presenting his work on MLL3 loss and metastasis initiation.

06.11.2025 14:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1