Claire

Congrats!!!!!

A starter pack including all attendees (that I can find for now)

Please let me know if I missed anyone!

#GRCPsychedelics

go.bsky.app/2ExXJcr

Somehow we got almost all the students and postdocs in one photo!!

Until next time #GRCPsychedelics 🫡

Sometimes colorless chemistry has its benifits

A reminder that I'm looking to talk to chemists impacted by the LA county fires.

#EatonFire #PalisadesFire #ChemSky

Flasks for centipedes

Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin We here report the first total synthesis of the antitubercular natural product evybactin, together with the structural reassignment of the previously proposed structure. The optimized synthetic metho...

Great paper by the group of Nathaniel Martin @led3hub.bsky.social with first author Vlad Lysenko in collaboration with Kim Lewis. A total synthesis of the antitubercular natural product evybactin allows reassigning its structure and providing material for in-depth testing. doi.org/10.1002/chem...

To find out more about the synthesis of α⁠-⁠ʟ⁠-⁠cyclodextrin, take a look at the article published earlier this year
www.nature.com/articles/s44...
#chemsky

Contrasteric Glycosylations of Cotylenol and 1,2-Diols by Virtual Linker Selection Many terpene glycosides exhibit contrasteric patterns of 1,2-diol glycosylation in which the more hindered alcohol bears a sugar; protection of the less hindered alcohol only increases steric repulsion. Here, we report a method for contrasteric glycosylation using a new sugar-linker that forms a cleavable, 10-membered ring with high efficiency, leading to syntheses of cotylenin E, J, and ISIR-050. Linker selection was aided by DFT calculations of side reactions and stereoselectivity, as well as conformational analyses using autoDFT, a Python script that converts SMILES strings to DFT-optimized conformational ensembles.

Congrats to Dylan and Stephen for their paper on diverse glycosylations of cotylenol en route to 14-3-3 molecular glues.

This work was expedited by autoDFT, a Python script that Stephen wrote to convert SMILES to DFT-optimized structures (and ensembles of conformers).

3 reactions set up in one day lets goooooooo!

10000000/10 jacket

Educational poster titled 'The Chemistry of Gold, Frankincense and Myrrh'. Features sections on how each is formed, their chemical components, and fun facts about them, accompanied by thematic illustrations including gold bars, frankincense and myrrh resins, and the three wise men. The design incorporates Christmas-themed graphics with a 'Merry Christmas' greeting at the bottom.

Discover the chemistry of gold, frankincense and myrrh in today's #AdventCalendar challenge with Thames Valley RSC 🔬🕯️🎄 @thamesvalleyrsc.bsky.social @compoundchem.com #ChemSky #EduSky

ᗪIᗪ YOᑌ KᑎOᗯ?

BACITRACIN was named by Balbina Johnson, lab supervisor at Columbia Med School, since the producing (Baci)llus was isolated from compound fracture of a child Margaret (Trac)y where it was (in)hibiting pathogenic bacteria and helping her overcoming a septic infection?

#IDSky 🦠 🧫 🧪

The breaks 100% worth it. Totally lets you reset your brain before the next 5 years startz

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...

Here’s a 3,5-dinitrophenol snowflake designed by our Head of Chemistry! ❄️

When your standards standard needs a standard