Sarah Najjar

We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.

#GastroEdPick Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force @cp-cell.bsky.social www.cell.com/cell/fulltex...

Very impressive seminar!

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
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So excited this paper is finally out!!!

Interoception and gut–brain communication The brain senses changes to the internal state of the body, eliciting responses that maintain homeostasis. Alhadeff and Yapici provide an overview of this process, termed interoception, with a particu...

Current Biology

Interoception and gut–brain communication
www.cell.com/current-biol...

The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract - Nature Reviews Gastroenterology & Hepatology Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by which neurons are sensitized in the gut, outlining sign...

NEW in #NatureReviewsGastroHep!

This Review on gut-brain axis & pain signalling in the gut
By Kim Meerschaert & Isaac Chiu
www.nature.com/articles/s41...

🔓 rdcu.be/d1dFo

🧪 #gastrosky #GIsky