@stephenrdoyle
Group Leader @ Wellcome Sanger Institute. UKRI Future Leaders Fellow. Molecular & computational biology of parasitic worms of humans and animals. https://helminthgenomics.sanger.ac.uk/ 🇦🇺Aussie dad of 🧒+👶^2.
Global diversity of soil-transmitted #helminths reveals genetic variation that impacts diagnostic targets
@stephenrdoyle.bsky.social @marinapapaiakovou.bsky.social @phylofacts.bsky.social @camvetschool.bsky.social @sangerinstitute.bsky.social
Global diversity of soil-transmitted #helminths reveals genetic variation that impacts diagnostic targets
@stephenrdoyle.bsky.social @marinapapaiakovou.bsky.social @phylofacts.bsky.social @camvetschool.bsky.social @sangerinstitute.bsky.social
Final chapter in @marinapapaiakovou.bsky.social 's PhD too - she'll be on the lookout for Postdoc positions soon, so please get in touch with upcoming opportunities!
Many thanks to a very large and diverse group of international collaborators for providing samples. We could not have done it without you.
Here, we look at how genetic diversity in mixed STH populations has the potential to impact qPCR-based diagnostics. Turns out, there is a lot of variation, and a lot of potential to cause misdiagnoses.
New paper, now in Nature Communications!
Thanks to a massive effort by PhD student @marinapapaiakovou.bsky.social, I am excited to share our work "Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets".
doi.org/10.1038/s414...
I am proud to see our latest work on hybridisation capture in soil-transmitted helminths, led by PhD student @marinapapaiakovou.bsky.social , now published in Molecular Ecology Resources. I am looking forward to scaling this up into larger populations. In the meantime, 🥳
doi.org/10.1111/1755...
Really nice experiment and paper, congrats!
Congratulations! 🥳
Job advert - Please share!
Mark Viney (lnkd.in/dwkZf7mG) and I are seeking a motivated postdoctoral fellow to work on drug treatment responses of soil-transmitted helminth and hookworm genomics in Southeast Asia.
Do reach out if you are keen!
www.jobs.ac.uk/job/DMR456/p...
We are advertising for a PhD position to study bacterial metabolites in C. elegans, funded by the MRC Microbes, Microbiomes and Bioinformatics training programme @uniofeastanglia.bsky.social @biouea.bsky.social. Open to UK and international students. www.findaphd.com/phds/project...
Very excited to see our latest work, led by @marinapapaiakovou.bsky.social , on @biorxiv-genomic.bsky.social !
Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture
doi.org/10.1101/2025...
Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture https://www.biorxiv.org/content/10.1101/2025.02.24.639427v1
globally, there are ~3500 described mosquito species in the Culicidae family and many of these are important vectors of disease but only a small percentage have genomic resources. we are launching a pilot project to generate high quality reference genomes for 100 important mosquito species [1/3]
Less than one week to apply - deadline 25th of Feb!
If you are from Latin America, work on helminths, and are interested in genetics/bioinformatics, this could be a great opportunity for you 👇
I am hiring! 2 year Post-Doc microbiologist to identify gut bacteria inhibiting fungal pathogens. Join new, expanding gut microbiome research group at @apcmicrobiomeirel.bsky.social and @uccmicrobiology.bsky.social in Cork. Further details and apply here:
ore.ucc.ie
Job ID: 084031
We're looking for a post-doc to work on anthelminthic resistance in a new pan-European project. It will involve generating and analysing targeted and whole-genome data from well-phenotyped livestock GIN populations.
Please get in touch if you have any questions.
www.jobs.gla.ac.uk/job/research...
Are you based in South America and work on helminths?
Join me & a great group of instructors on the Helminth Bioinformatics course in Montevideo during 18–24 May!
We'll cover expenses, you just need to come, interact, and learn.
Please share & apply!
t.co/Dlj4DyG1ul
📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41...
A comment @natrevgenet.bsky.social from @katholt.bsky.social and me
Good suggestion! I had remembered @zamanian.bsky.social and @wheelerlab.bio had done this, but forgot to look it up 🤦♂️
Any suggestions for tracking worms like C.elegans and other things from live imaging fluorescence data? Would like an open source tool.
Congratulations Megan and team! 🥳
Wow, this looks awesome 🤩
Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system https://www.biorxiv.org/content/10.1101/2025.02.01.636063v1
Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq https://www.biorxiv.org/content/10.1101/2025.02.02.636107v1
Really fun to write this paper on spatial transcriptomics with Sarah. It’s an exciting technique that has a lot of potential in Parasitology for new insights.
This is too much fun to be called work. #scalingup @sangerinstitute.bsky.social #ukriflf
Don’t get them wet… 😬
Today was a great reminder that I work with some really amazing people. Shout out to Joana and Javi for kicking big goals today 🤩 @sangerinstitute.bsky.social
We share a lot of our ideas, code, datasets (that we spend years sanitizing) early. Often way before we release preprints. We do this so that others can use, build on, improve & even "beat" our approaches. But I want to say a few things about some simple expectations 1/
