Justin Randall (Randall Lab, UMKC)

β-Hairpin Antimicrobial Peptides: Class Diversity and Sequence Analysis Interest in antimicrobial peptides has increased dramatically over the last few decades as researchers continue to explore their potential as alternatives to small molecules, as well as their applicat...

Our lab has a new review on beta-hairpin antimicrobial peptide diversity out in @pubs.acs.org as part of the special issue celebrating Robert E. W. Hancock. Please have a look and share!

pubs.acs.org/doi/10.1021/...

UMKC is looking for a NTT faculty in biology to start in January. UMKC is a great place to work and Kansas City awesome. Please apply if interested! Info below:

We are hiring new a Tenure-track Assistant/Associate Professor in my division at UMKC! If you are interested, please apply by going to the link below and searching for Job ID 55628. It is a really wonderful place to live and work!

erecruit.umsystem.edu/psc/tamext/K...

🎉🎉🎉🎉 Congrats! Well deserved!

So very frustrating. Months of work wasted… 😫

Very frustrating 😔

This will be an exciting seminar! Don't forget to sign up and attend if interested!

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

https://go.nature.com/4iECjJz

We can only combat this bias by celebrating #WomenInStem loud and proud. Women like Lilian, Emmy, McClintock, Karikó... of course the list goes on & on..

Please hit me with more fantastic women to celebrate. I'll do my best to work them into lectures.

To close: happy #InternationalWomensDay!

18/n

Here is another fellow AMP GRCer
@jarvist.bsky.social

I've also now made a Starter Pack for the #AntimicrobialPeptide field here:

go.bsky.app/JLHHzt1

Please let me know who I am missing! This is a very incomplete list so far. I also expect many will join Bluesky later. I will happily keep populating this list! 📣🧬🦠

Thanks for this Mark!

At the AMPs GRC? Come stop by our poster later today or chat in person with any of our committee members! iAMPNet is free to join!

Last chance! Checkout this free webinar on Antimicrobial Peptides happening soon!

If you’re looking to explore lipid cell heterogeneity and dynamics at single-cell level from a fresh perspective, we encourage you to check out this review on single-cell lipid biology!!!

If you do research involving antimicrobial peptides, please consider joining the international AMP Network (iAMPNet) and follow us @iampnetwork.bsky.social

We provide monthly webinars and access to mentorship and networking opportunities with in the field

To learn more and join visit iampnet.com

Monthly Skype a Scientist Support Squad Help us increase our monthly donations by $1000/month

The posting about @skypeascientist.bsky.social's need for monthly support is starting to work! Thank you to everyone who has become a monthly donor 🥹

We're still at ~80% of the monthly supporters we had in 2021, so I'm trying to claw us back to there. We can do it!

Join us!
givebutter.com/uA8ubg

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales - Nature Communications In this work, authors probe the molecular mechanism of re-emerging CHL susceptibility in Malawian Enterobacterales isolates, where they identify a stable truncation of resistance genes by insertion se...

As my first post on bsky post, I thought I'd share a recent paper of ours published in
@naturecomms.bsky.social
.

Here we use various techniques to determine the molecular mechanisms for an observed rise in chloramphenicol susceptibility at the same time as an increase in ESBL resistance.

Fantastic resource. Thanks for putting this together Georgia!

Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity - Nature Biomedical Engineering A high-throughput mutation-scanning method for interrogating sequence variation in antimicrobial peptides facilitates the understanding of sequence–structure–function relationships affecting the membr...

For those interested in how we might rapidly modify antimicrobial peptides to be less toxic, take a look at my most recent publication!

www.nature.com/articles/s41...