Justin Wheler (he/him)

Abstract Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus. In addition, the vaccine protected mice from other viruses (SARS-CoV-2, SARS, SCH014 coronavirus), bacteria (Acinetobacter baumanni), and allergens. Protection was mediated by persistent ovalbumin-specific CD4+ and CD&+ memory T cells that imprinted alveolar macrophages (AMs), enhancing antigen presentation and antiviral immunity. Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung. These results reveal a class of "universal vaccines" against diverse respiratory threats.

The study has been published in Science. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

NOTE: THIS IS PRECLINICAL.

🧪🧵⬇️

Wow! Hope the trials bear out this potential. Science matters!

Phrases like “I’ve been told,” “I hear,” or “people say” serve several purposes:
-Plausible deniability
-Signal amplification
-Dog whistling
-Test ballooning
-Deflecting

And it's just a whole lot easier than actually investigating the severity or sources of problems.

We can’t stop being outraged by war crimes. This is evil

‘No one quite like her’: meet the female colleagues who inspire these award-winning women in science To mark International Women’s Day, Nature asked winners of its awards programmes to nominate a colleague who brings out the best in them.

To celebrate International Women’s Day, held each year on 8 March, Nature asked six previous winners of awards given in partnership with Nature to name a woman who has had a positive impact on their scientific career and well-being. 🧪

World map highlighting countries where polio has been detected in the last 12 months

CDC issued a Global Polio Level 2 Travel Health Notice advising enhanced precautions

Tragic. We had polio almost eradicated, but disruption to vaccination campaigns due to COVID, global instability, defunding & vaccine hesitancy have led us here

#VaccinesWork
🧪

wwwnc.cdc.gov/travel/notic...

Optical illusion of a woman bent over some papers. Her sunglasses are pushed up and she is wearing a hair band so the top of her head looks exactly like a Muppet face

Sorry I know the world is in a terrible fix but I've been laughing at this for ten minutes now

She just literally makes shit up. She just lies. I know people have said this. And yes I agree. But here we are. Right there. My god golly

🤨Fox News showed "American" interceptor drones in action, but there's a catch... the video shows Ukrainian STING drones shooting down Russian drones.

Sea levels already ‘much higher’ than many scientists had estimated Measurements of actual global levels show big impact of climate change, especially in Asia, study shows

Sea levels are up to one foot higher than previous research suggested.

Less than one per cent of 385 surveys accurately measured how high seas have already risen, a new study in
@nature.com reveals.

www.ft.com/content/eb58...

Texas just set a series of records on the grid:
• Solar peaked at 31.3 GW, 10 GW above California’s record
• At one point, renewables supplied 83% of total generation
• Battery discharge reached 8.6 GW
• Batteries covered 16% of load at peak

This is incredible. A must-watch.

Russia 'deliberately and brutally' execute 337 Ukrainian POWs by end of 2025, ombudsman says "Russia has turned torture into state policy and uses it as a weapon," Ukraine's Human Rights Ombudsman, Dmytro Lubinets, said.

⚡️Russia 'deliberately and brutally' execute 337 Ukrainian POWs by end of 2025, ombudsman says.

"Russia has turned torture into state policy and uses it as a weapon,” Ukraine's Human Rights Ombudsman, Dmytro Lubinets, said on March 3 during a meeting of the U.N. Human Rights Council.

Artist: @dccartoonist.bsky.social

Shahed type OWA-UAS stats Feb2026 [per UA Air Force Reports]

Total: 5059
Claimed Intercepted: 4410
(Official: 3238 Shahed type OWA-UAS)
Hits: 546 (649 Not Intercepted)
Interception Rate: ~87%

Median Attack: 129 drones
Average Decoy Rate: ~37%

Make it stop

Carbon dioxide overload, detected in human blood, suggests a potentially toxic atmosphere within 50 years - Air Quality, Atmosphere & Health Air Quality, Atmosphere & Health - Anthropogenic activities are increasing the amount of carbon dioxide (CO2) in the atmosphere. There is mounting experimental evidence that lifetime exposure...

I hadn’t thought about the direct health impacts of higher atmospheric CO2 before. Maybe this will break through to leaders when the impacts are duct to each human, within our or our children’s lifetimes?
We need to urgently stop adding CO2 to the atmosphere!

link.springer.com/article/10.1...

🤦

WELL NOW, would you look at that? A massive, 24-YEAR-LONG study of MORE THAN 1.2 MILLION people in Denmark found NO LINK between aluminum in childhood vaccines and autism, asthma, OR chronic disorders.

Aluminum is an ADJUVANT.

It ENHANCES your immune response to a vaccine.

That’s it.

Alberta immigrants say they’re seeing an uptick in anger, rise of racist narratives Alberta resident Shamaila Akram says she can handle the increase in racial slurs and derogatory comments being thrown at her, but she worries about her newcomer and immigrant clients.

This article is from July 2025. Imagine how much worse it has gotten in Alberta. Now that the Premier has blamed immigrants for everything, the hate will escalate exponentially.
#ABpoli #ABleg #Cndpoli

www.ctvnews.ca/calgary/arti...

The political effects of X’s feed algorithm - Nature Among users initially on a chronological feed, 7 weeks of exposure to X’s algorithmic feed in 2023 shifted political attitudes and account-following behaviour in a more conservative direction compared...

Brainwashing, 2026 edition. This paper shows how X's algorithmic feed shifts people's views rightwards. It's a sophisticated, highly effective form of reorientation. And it is utterly chilling.
If you're still on that platform, unhook yourself now.
www.nature.com/articles/s41...

"“Do you move a school and a hospital away from the noise, or simply move the cars?” says [Colorado State U. Prof David] Rojas-Rueda, who was involved in a study that found Barcelona’s Superblock model of pedestrian-first zones led to major reductions in air and noise pollution.

Ukraine is the biggest and most consequential of all the American betrayals | Simon Tisdall As the war enters its fifth year, it’s time for Europe to take the fight to Putin on its own terms and tell Trump to get lost, says Guardian foreign affairs commentator Simon Tisdall

The open-minded, freedom-loving rainbow Europe of democracy and the rule of law is a living rebuke to these lumbering Frankenstein’s retro-monsters and their hard-right emulators.

They revile and fear it.

Like Ukraine, it stands in their way.

www.theguardian.com/commentisfre...

“it’s imperative that Europeans, and the pre-midterms, anti-Trump American majority, begin to speak with one voice – and match words with actions. And where better to start than in Ukraine, the actual and symbolic frontline in the battle between liberal democracy and the Trump-Putin axis?”

Ukraine is the biggest and most consequential of all the American betrayals | Simon Tisdall As the war enters its fifth year, it’s time for Europe to take the fight to Putin on its own terms and tell Trump to get lost, says Guardian foreign affairs commentator Simon Tisdall

www.theguardian.com/commentisfre...
Well written

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Here's a 2024 letter from Danielle Smith to Justin Trudeau complaining about federal immigration limits affecting Alberta.

www.alberta.ca/system/files...

#Alberta #abpoli #Canada #cdnpoli

In Alberta we literally burn money because of our inept Premier and her government.

Later today, Premier Smith with all the racism and xenophobia she can muster, will blame immigrants and newcomers for Alberta's fiscal challenges.

And the RCMP seems to be so behind on their investigations? Hmm.

In 2024, Danielle Smith wrote a letter to Justin Trudeau to complain that they didn't get *more* immigrants than their planned allotment. (She also wanted more Ukrainians specifically, and we all know why).
Receipts:

Alberta is calling… “hey, can you come over so that when I get in trouble for not doing my chores and spending money on stupid stuff I can blame you?”

NEW: Western sources continue to indicate that Russian President Vladimir Putin’s objectives are not limited to control of Ukrainian territory — in line with ISW’s longstanding assessment based on repeated Kremlin public statements.

Read the full report: isw.pub/UkrWar021926

Other Key Takeaways