Katherina Siewert

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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity - Nature Communications While static structures can provide insight into T cell receptor (TCR) antigen specificity, this often fails and auxiliary information is needed. Here the authors show, by focusing on an HLA-A3-bound ...

TCR specificity can be hard to understand. See our latest work showing how dynamic allostery in a peptide/MHC complex can control TCR specificity towards a public neoantigen. Great collaboration with Chris Klebanoff and team at @mskcancercenter.bsky.social #immunosky
doi.org/10.1038/s414...
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Graphic shows dramatic reduction in polio, rubella, mumps, measles, and hepatitis A cases after the introduction of vaccines for each disease.

Disease prevalence in US states before & after vaccine introduction

Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪

👋 would like to be included

Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Ac...

Concept for regulatory T cell tests on sensitizing chemicals:

www.mdpi.com/2305-6304/12...

Unique and common TCR repertoire features of Ni2+‐, Co2+‐, and Pd2+‐specific human CD154 + CD4+ T cells Ni2+-, Co2+-, and Pd2+-specific CD4+ T cells can be detected by a short-term CD154 upregulation assay. Overrepresentation of certain individual gene segments or a CDR3 histidine represent distinct TC...

We are interested in metal-specific TCRs:
onlinelibrary.wiley.com/doi/full/10....