Danielle Grotjahn

The molecular basis of force selectivity by PIEZO2 Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...

“I’m grateful to be included in a journal with such a strong legacy in defining and advancing the field of cell biology.”— Dr. Danielle Grotjahn (@nanigrotjahn.bsky.social). JCB is where the world meets your research. Learn more. hubs.la/Q0442hKP0

Bridging Cellular and Structural Biology Through Cryo-electron Tomography - ASCB Cellular cryo-electron tomography (cryo-ET) holds the grand promise of integrating cellular architecture with molecular structure. Yet, for many cell biologists, this method can seem technically…

From cartoon models to quantitative structural maps: learn how cryo-electron tomography is reshaping studies of cellular organization. Danielle Grotjahn, Ph.D., shares where cryo-ET excels, its challenges, and how it fits into today’s imaging toolbox.

Are you a cell biologist who secretly thinks cellular cryo-electron tomography is just George Palade-era EM, but fancier?

Join this webinar to see how modern #teamtomo has shifted from pretty pictures to quantitative, local membrane biology, and how that changes the questions we can ask.

🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭
We are looking for a motivated Postdoc to join our interdisciplinary team.
📩 Interested? Check out the job advert:
www.imm.uzh.ch/dam/jcr:cb17...

👉 More info on the lab: www.weiss-laboratory.com
Please share with interested colleagues!

Scientists measure cellular membrane thickness inside cells for the first time

Reported in #JCellBiol, a method developed in the lab of Associate Professor Danielle Grotjahn (@nanigrotjahn.bsky.social) measures membrane thickness directly inside intact cells and identifies ATP synthase clusters in curved, unusually thick membrane regions.

You’re brave! As a fellow yapper, I’d be terrified of losing the audience—but clearly the data say it was a hit 😄

And congrats to the devs of an alternative method for measuring membrane thickness. Excited to see new tools expanding in parallel!

#teamtomo is clearly more than structural biology, and quantitative cell bio is where it can shine! 🌞https://bsky.app/profile/deglushk.bsky.social/post/3m4x2nh73nc2e

congrats to co-first authors @mmedina300kv.bsky.social and @attychang.bsky.social + @hamid13r.bsky.social @baradlab.com and the rest!

Check out a nice Bsky-torial of the article from co-corr author and surfomorpho ally @baradlab.com bsky.app/profile/bara...

#teamtomo gets another quantitative cell biology tool!

We extend our Surface Morphometrics pipeline to measure membrane thickness.

Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).

Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.

JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬

#teamtomo @attychang.bsky.social

Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...

Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...

We will announce a #postdoc opening in January. Cryo-ET and virus replication. If you're interested you can DM or email me already now. More info will follow!

What an honor to see @attychang.bsky.social’s work featured in @jcb.org The Year in Cell Biology 2025 collection! Even more special that it coincides with my first #cellbio2025 conference 🙂

s/o to co-authors @baradlab.com @hamid13r.bsky.social @zidlab.bsky.social

#teamtomo #cellbio25

Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂

Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.

s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com

Exciting !

Thank you to all of our plenary speakers for sharing your incredible research with us at #ASBMB2025! @nanigrotjahn.bsky.social @ajknights7.bsky.social Michelle Haber and Randal Halfmann. We have loved having you all in Brisbane and hearing about your labs awesome work! 🦠🧬🧪🧫🔬

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026

What an inspiring few days at the #WEHeraeusSeminar! Great science, lively discussions, and lots of fun with the amazing community of #cryoEM, #StructuralBiology & #Microscopy. Huge thanks to everyone!

We all love colours, especially, when they can be generated automatically! Fantastic talk by Danielle Grotjahn @nanigrotjahn.bsky.social linking method development, structural biology and cell biology! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Excited to travel to Germany 🇩🇪 for the WE-Heraeus-Seminar: Cryo‐EM on the Move: New Applications and Challenges! ❄️🔬🧊

I look forward to hearing what everyone is cooking up to make cryoEM better 📈 faster 🏃‍♀️ stronger 💪 😎

www.we-heraeus-stiftung.de/veranstaltun...

To be considered for this session, please include the following in your submission:

🧫 Topic: Advances in Cell Biology Tools and Technologies
🔬 Subtopic: CryoEM/CryoET
🎤 Format: Minisymposium Talk

Abstract deadline: Sept 3
submissions.mirasmart.com/ASCB2025/Spl...

🚨 #teamtomo!🚨
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??

Ending the week on a high note in SLC with a visit to @uofubiochem.bsky.social after an inspiring M&M 2025 meeting!

It was officially released just today, so you’re only a few hours behind 🙂

Thanks to @baradlab.com for the many conversations about segmentation/morphometrics that helped shape this article and @attychang.bsky.social for help with figures.

Segmenting cryo-electron tomography data: Extracting models from cellular landscapes Cryo-electron tomography provides an unprecedented view of cellular architecture, yet extracting meaningful biological insights remains challenging. S…

I have lots of opinions—but for your sake, I’ve limited them to segmentation in cryo-ET for this article 😉
www.sciencedirect.com/science/arti...

#teamtomo

A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!

www.sciencedirect.com/science/arti...