Gert Bange

Thank you!!!!

The #SubtiWiki paper of the month for February has been chosen. It reports about AppppA-mediated control of protein acetylation. Congrats to the groups of @bangebalcony.bsky.social and collaborstors!

subtiwiki.uni-goettingen.de/wiki/index.p...

Structural basis of Cas8-independent Cas3 recruitment in Type I-F2 CRISPR–Cas Abstract. CRISPR–Cas systems provide adaptive immunity in prokaryotes by targeting and degrading invasive genetic elements. Among them, the Type I-F2 syste

Great collaboration with the labs of Axel Innis and @patrick-pausch.bsky.social on Typ I-F2 CRISPR-Cas. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

AP4A functions as a regulatory switch of protein acetylation, connecting stress signaling to central metabolism.

@synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

Enjoy the reading:

www.nature.com/articles/s41...

AP4A functions as a regulatory switch of protein acetylation, connecting stress signaling to central metabolism.

@synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

Enjoy the reading:

www.nature.com/articles/s41...

6/6) Big thanks and congrats to Monika Jasnauskaite et al. for their relentless work 🤜🤛! On Bluesky: @jjuozapaitis.bsky.social @mftorresj.bsky.social @evogytis.bsky.social @bangebalcony.bsky.social @ingasongailiene.bsky.social. Shout out to our funders @erc.europa.eu, @embo.org, @dfg.de, and LMT.

Structural basis of quinone sensing by the MarR-type repressor MhqR in Staphylococcus aureus | mBio Staphylococcus aureus is a major human pathogen that can cause life-threatening infections in humans. However, treatment options are limited due to the prevalence of antimicrobial-resistant isolates i...

journals.asm.org/doi/10.1128/...

Where and how many: evolutionary diversification of a molecular switch regulating flagellar patterns | Journal of Bacteriology The bacterial flagellum is a complex, rotary motor that powers bacterial motility. It consists of three main parts: the basal body, the hook, and the filament (Fig. 1A) (reviewed in: [1–3]). The basal...

Bacterial swimming isn’t random - it’s engineered. 🦠
Discover how a conserved molecular switch (FlhF/FlhG) controls where and how many flagella bacteria build to navigate their world.

@synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

journals.asm.org/doi/10.1128/...

Nachgefragt: Prof. Dr. Gert Bange im Interview
www.biospektrum.de/artikel/nach...

@bangebalcony.bsky.social

Molecular Insights into the Substrate Recognition and quasi-unidirectional Catalysis of OpaE, an Atypical Fungal Enzyme from the Asp/Glu Racemase Family Enzymes of the Asp/Glu racemase family, mostly found in bacteria, typically catalyze bidirectional reactions with similar rate due to their pseudo-symmetrical structure and minimal differences between...

www.jbc.org/article/S002... @synmikro.bsky.social @unimarburg.bsky.social

Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1 The eukaryotic ribosome consists of four ribosomal RNAs (rRNAs) and around 80 ribosomal proteins (r-proteins). Most r-proteins, due to their extensive interactions with rRNA, contain highly basic regi...

www.biorxiv.org/content/10.1...

Membrane binding properties of the cytoskeletal protein bactofilin A combination of cell biological, biochemical, and computational approaches characterizes the conserved membrane-targeting sequence of bactofilins and reveals a mutual influence of membrane binding an...

In @elife.bsky.social: Membrane binding properties of the cytoskeletal protein bactofilin doi.org/10.7554/eLif...

What Gut Bacteria Like An international team of researchers has addressed a question that has received little attention to date: how do beneficial gut microorganisms perceive their environment? Led by Prof. Dr Victor Sourji...

How do beneficial gut microbes 'read' their habitat? A study by Victor Sourjik`s lab together with @bangebalcony.bsky.social investigated the chemical preferences of gut microbes. The study highlights the important role of #microbes in #health and #ecosystems. 👉 s.academiccloud.de/zSKBRb

It is out now 🥳🥂
I am very happy to be part of this nice collaboration in which we were able to characterize different bacterial chemoreceptors and their ligand specificities. Amazing teamwork with Wenhao Xu, the Sourjik lab, @bangebalcony.bsky.social, et. al 🤩

👇👇👇
www.pnas.org/doi/10.1073/...

Specificities of chemosensory receptors in the human gut microbiota | PNAS The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical sig...

www.pnas.org/doi/10.1073/... @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

In @elife.bsky.social: Membrane binding properties of the cytoskeletal protein bactofilin doi.org/10.7554/eLif... @synmikro.bsky.social @unimarburg.bsky.social

👍🏼COOL🆕Christof Wegscheid-Gerlach @cwgmr.bsky.social (Koord. d. eh.LOEWE-GLUE) übernimmt Staffelstab🧪von Prof. Stefanie Dehnen (ehem.👩🏼‍🔬bei LOEWE-MOSLA, heute Direktorin des Instituts für Nanotechnologie am KIT in Karlsruhe).Wir gratulieren dem🆕Direktor des Chemikum #Marburg!!! @unimarburg.bsky.social

Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing rece....

From bacterial virulence to human disease, researchers gathered in Marburg exploring how Ap₄A and other dinucleoside polyphosphates are rewriting the rules of cellular signaling across life. 🚀 Huge thanks to all speakers, participants, and organizers. 🙌 @synmikro.bsky.social @unimarburg.bsky.social

Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing rece....

From bacterial virulence to human disease, researchers gathered in Marburg exploring how Ap₄A and other dinucleoside polyphosphates are rewriting the rules of cellular signaling across life. 🚀 Huge thanks to all speakers, participants, and organizers. 🙌 @synmikro.bsky.social @unimarburg.bsky.social

www.uni-marburg.de/de/aktuelles... @unimarburg.bsky.social

🍾 GOOD🆕s:➡️𝗗ü𝗿𝗿𝗲𝗮𝗻𝗽𝗮𝘀𝘀𝘂𝗻𝗴➡️𝗔𝗻𝘁𝗶𝗳𝗲𝗺𝗶𝗻𝗶𝘀𝗺𝗲𝗻➡️𝗽𝗲𝗿𝘀𝗼𝗻𝗮𝗹is. 𝗠𝗲𝗱𝗶𝘇𝗶𝗻𝘁𝗲𝗰𝗵𝗻𝗶𝗸: 38𝗠𝗶𝗼.€ 𝗳ü𝗿 hess.F𝗼𝗿𝘀𝗰𝗵𝘂𝗻𝗴:1️⃣𝗟𝗢𝗘𝗪𝗘-𝗭𝗲𝗻𝘁𝗿𝘂𝗺,4️⃣𝗦𝗰𝗵𝘄𝗲𝗿𝗽𝘂𝗻𝗸𝘁𝗲+🔟𝗟𝗢𝗘𝗪𝗘-𝗣𝗿𝗼𝗷𝗲𝗸𝘁𝗲-𝗪𝗶𝗿 🫶🏼 𝗴𝗿𝗮𝘁𝘂𝗹𝗶𝗲𝗿𝗲𝗻! @tuda.bsky.social @jlugiessen.bsky.social @goetheuni.bsky.social @unikassel.bsky.social @unimarburg.bsky.social ➡️ wissenschaft.hessen.de

A conserved nuclease facilitates environmental DNA uptake Abstract. Bacteria acquire new traits through the uptake of genetic material from the environment, a process requiring DNA processing. However, the molecul

Rebekka is presenting their recent publication in #NAR
academic.oup.com/nar/article/...
Collaboration with @thanbichlerlab.bsky.social and also with @bangebalcony.bsky.social - thus beautiful crystal structures involved
#BACELL2025

www.uni-marburg.de/de/aktuelles... @unimarburg.bsky.social

A conserved nuclease facilitates environmental DNA uptake Abstract. Bacteria acquire new traits through the uptake of genetic material from the environment, a process requiring DNA processing. However, the molecul

academic.oup.com/nar/article/... @synmikro.bsky.social @unimarburg.bsky.social

www.uni-marburg.de/de/aktuelles...

Thank you for being a part of RobuCop!@olallalab.bsky.social @bangebalcony.bsky.social @danielschindler.bsky.social @hoeferlab.bsky.social @schullerjm.bsky.social @georghochberg.bsky.social

FlhG Cooperates With the Cell Cycle Regulator GpsB to Confine Peritrichous Flagella in B. subtilis FlhG (orange, with activator helix in green) regulates peritrichous flagellation in Bacillus subtilis by interacting with the C-ring protein FliY (gray, N-terminus in red) and the cell wall regulator....

onlinelibrary.wiley.com/doi/10.1111/... @synmikro.bsky.social @unimarburg.bsky.social

How to Tell an N from an O: Controlling the Chemoselectivity of Methyltransferases S-Adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) are important enzymes in numerous biological pathways. They share a common SN2 mechanism but act on different nucleophilic substrates i...

If you want to know how to tell an N from an O, you can get some ideas in our new paper. This was a great team effort, introducing us to new methods: MD w/ Ferran Feixas & Marc Garcia Borràs (Girona) + HDX-MS w/ Wieland Steinchen & Gert Bange @bangebalcony.bsky.social
pubs.acs.org/doi/10.1021/...

Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts - npj Biofilms and Microbiomes npj Biofilms and Microbiomes - Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts

Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts

NPJ Biofilms and Microbiomes - from Copenhagen University Hospital and University of Copenhagen

www.nature.com/articles/s41...

A doctor is born: congratulations Victor Zegarra!!! @synmikro.bsky.social @unimarburg.bsky.social