Daniel Drucker

In normal healthy human male subjects, acute GIP infusion does not modulate splanchnic blood flow academic.oup.com/jcem/advance...

Dietary restriction in aging and longevity - Nature Aging Schmauck-Medina et al. review dietary restriction as a class of geroprotective interventions, considering evidence across species, conflicting data, mechanisms, side effects and pharmacological mimeti...

Dietary restriction strategies for #aging #healthspan www.nature.com/articles/s43...

Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery - Nature Metabolism Tanycyte-derived extracellular vesicles are shown to regulate feeding diurnality and metabolic balance through insulin precursor-mediated targeting and delivery of mTORC components to hypothalamic neu...

Here tanycyte-derived EVs identified as regulators of feeding diurnality through insulin precursor-directed targeting and delivery of mTORC components to hypothalamic neurons #diabetes #obesity www.nature.com/articles/s42...

Do obesity drugs treat addiction? Huge study hints at their promise Study of 600,000 US military veterans shows that those who took anti-obesity medications were less likely to develop some complications of substance-use disorders.

Are substance use disorders the next frontier for GLP-1 medicines.? Moving the needle from real world data to large RCTs will be critical www.nature.com/articles/d41...

New from Megan Capozzi @UW Postprandial glycogen repletion and the surprising role of glucagon insight.jci.org/articles/vie... @insight.jci.org

GLP-1 medicines have multiple direct and indirect effects that modify cardiovascular risk. Here Kyle Medak @SinaiHealth and colleagues identify an important role for the VSM GLP-1R in the reduction of blood pressure #hypertension @JCI_insight @uoftmedicine insight.jci.org/articles/vie...

Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut - Nature Reviews Gastroenterology & Hepatology Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal...

A roadmap towards developing metabotherapies for intestinal disease. #microbiota www.nature.com/articles/s41...

The BELIEVE study, the efficacy and safety of intravenous bimagrumab and open-label subcutaneous semaglutide, alone or in combination, in adults with #obesity www.nature.com/articles/s41...

Lipidated Interleukin-22 Reduces Body Weight And Spares Lean Mass In Mice By A Novel Gut Acting Mechanism Additive To GLP-1 Agonism A novel long-acting IL-22 analogue drives weight loss and improves glucose control through a novel intestinal mechanism-of-action that acts additively with GLP-1 drugs. By preserving lean mass and enh...

New preclinical studies identify lipidated IL-22, a pleiotropic gut hormone secretagogue, as a novel anti- #obesity treatment with multiple modes of action www.cell.com/molecular-th...

Is persistence improving with new #weightloss medicines? www.jmcp.org/doi/10.18553...

The important role of IL2RA in immune tolerance and β-cell protection highlighted by early onset type 1 #diabetes diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...

The intestinal microbiota as a key modulator of acute graft-versus-host disease - Nature Reviews Cancer In this Review, Paredes et al. discuss preclinical and clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particu...

The #microbiota driven road towards development of personalized therapies for patients receiving allo-HCT, integrating #microbiome profiles with individual risk data #GVHD www.nature.com/articles/s41...

Studies in mice define endocrine-exocrine beta cell-derived CCK signaling as a bona fide driver of #obesity associated PDAC development and uncover avenues to target the endocrine pancreas to subvert exocrine tumorigenesis. #pancreaticcancer www.nature.com/articles/s41...

Obesity as a catalyst for neurodegeneration - Nature Metabolism In this Perspective, mechanisms by which overnutrition and obesity contribute to neurodegeneration are discussed.

Obesity and neurodegeneration www.nature.com/articles/s42...

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

ACHIEVE-3 Oral semaglutide vs. Orforglipron #T2D www.thelancet.com/journals/lan...

ACHIEVE-3 Orforglipron (12 & 36mg) vs. Oral semaglutide at doses (7 & 14mg) approved for #T2D #diabetes investor.lilly.com/news-release...

GlucoseGo: a simple tool to predict hypoglycaemia during exercise in type 1 diabetes - Diabetologia Aims/hypothesis This study aimed to develop an accessible tool, derived using machine learning, to predict hypoglycaemia risk at the start of exercise and to provide clear, rapid risk assessment to su...

A simplified model GlucoseGo for predicting #hypoglycaemia during #exercise #T1D @diabetologiajnl.bsky.social
link.springer.com/article/10.1...

A new role for the ion channel VRAC in balancing nutrient absorption and antimicrobial defense in enterocytes to safeguard gut homeostasis www.nature.com/articles/s41...

Preventing obesity-related cancer with the revolution in obesity management: the challenges of undertaking a clinical trial and potential solutions - British Journal of Cancer British Journal of Cancer - Preventing obesity-related cancer with the revolution in obesity management: the challenges of undertaking a clinical trial and potential solutions

How to navigate the evidence-based road to reducing rates of #obesity associated #cancer www.nature.com/articles/s41...

The early evolution of predictive autoimmune responses in children on the path to #T1D development n the TRIGR study www.nature.com/articles/s41...

Microbial-derived 3-phenylpropionic acid orchestrates immune-progenitor cell crosstalk to promote beige adipogenesis and energy expenditure The role of gut microbial metabolites in adapting to cold environments is not well understood. Li et al. reveal that cold-induced expansion of P. copri produces 3-PPA, which activates an immune-adipoc...

Based on studies in mice identifying P. copri as a key microbial mediator via macrophages & T cells of cold-induced adipose remodeling and thermogenesis, the authors propose microbial metabolites as potential metabolic therapies #obesity @Cell_Metabolism www.cell.com/cell-metabol...

The use of semaglutide as an add-on therapy in patients with LADA AbstractIntroduction. Semaglutide, a GLP-1R agonist (GLP-1RA), has demonstrated high efficacy in the management of type 2 diabetes (T2D). Few data in liter

Semaglutide as an add-on treatment to insulin exerted relevant clinical beneficial effects on the glycometabolic control in patients with LADA #diabetes academic.oup.com/jcem/advance...

Studies of mitochondrial activity in mice #obesity reveal that microRNA let-7 in sperm reprograms offspring metabolism by modulating mitochondrial function during early development
www.nature.com/articles/s41...

New from Klaus Kaestner Foxl1 orchestrates key events during the epithelial transition of the fetal mammalian gut via signaling in telocyte progenitors www.nature.com/articles/s41...

Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes - Diabetologia Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes mellitus. Despite its importance, non-adherence remains a prevalent issue, with...

Beyond the next incremental gain in #weightloss and A1c reduction, the important opportunity for improving cardiometabolic health requires improving adherence and persistence @diabetologiajnl.bsky.social
link.springer.com/article/10.1... @ #diabetes

P2 #weightloss data #obesity for an emerging triple G agonist in China, mean baseline weight 92.2 kg link.springer.com/article/10.1...

Here the authors propose that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme that controls Adipose tissue thermogenesis is a therapeutic target for age-related #obesity www.nature.com/articles/s41...

Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes - Nature Metabolism Free fatty acids drive uncoupled respiration in white adipocytes, mediated in complex with ATP/ADP carriers, to modulate thermogenesis and cold tolerance in obese thermoneutral-adapted mice.

Studies in mice suggest that uncoupled respiration in white adipocytes contributes to whole-body energy expenditure and could be a promising target for #obesity treatment www.nature.com/articles/s42...

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Preclinical studies suggest that targeting immunometabolic pathways with a glucokinase activator may offer a therapeutic strategy to alleviate cardiac dysfunction and reduce infarct vulnerability in #T2D www.nature.com/articles/s44... #CVD