Jatin Nagpal

Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.

www.science.org/doi/10.1126/...

Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic steroid hormones, including the anti-inflammatory drug prednisolone. This microbial activity is enriched in Crohn’s di...

Gut bacterial metabolism of steroid hormones

Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...

🚀 #ALBADiversityWeek 2025 starts today! We celebrate diversity & intersectionality by highlighting key activities and sharing valuable resources.
👀 Stay tuned all week as we revisit achievements and launch new initiatives. Share our posts to join the #GlobalDiversityAwarenessMonth celebration. 🧵

From cognition in the body to the body in cognition Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.

New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...

Had a great time discussing ‘What brain is the best to study disorders of behaviour’. Thanks to my fellow panelists and the audience for an enagaging session at European College of Neuropsychopharmacology (ECNP) 2025 meeting in Amsterdam.

#ECNP2025

Reaffirming the value of model organisms in training scientific minds | @natcellbio.nature.com

www.nature.com/articles/s41...

What is the best brain to study disorders of behavior? Great discussion at @ecnp.eu moderated by @jatinnagpal.bsky.social with inputs from @ribeirocarlitos.bsky.social @emreyaksi.bsky.social @eknapska.bsky.social & Hannah Clarke #ecnp2025

Congrats Surojit! Look forward to reading this.

Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.

Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.

www.science.org/doi/10.1126/...

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Great to see our review on microbiome, exposome and cognitive development out in @annualreviews.bsky.social.

@apcmicrobiomeirel.bsky.social
@uccresearch.bsky.social

#MicrobiomeSky #Gut-Brain

Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival Introduction We live in a world split between mosquito magnets and those lucky enough to remain (nearly) untouched. The reasons why some people attract more mosquito bites than others remain largely m...

Did I just read the best abstract ever? 😁

www.biorxiv.org/content/10.1...

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors. Physiology seeks to elucidate the intricate network of interact...

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits.

www.biorxiv.org/content/10.1...

Professor: 'It's hard to reassure international researchers about their safety in Ireland' Professor Lokesh Joshi of University of Galway says recent racist attacks will affect Ireland’s ability to attract world-class researchers.

“Recognising the “New Ireland” means embracing its diversity, not as a problem to manage, but as a strength to celebrate.”
Well articulated by Prof. Lokesh Joshi.
www.thejournal.ie/readme/racis...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.

New RESOURCE!

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co

#microbiomesky #microsky

www.nature.com/articles/s41...

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.

Please Share

@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...

🧠 How does your gut talk to your brain? We’re diving into the Gut-Brain Axis at #BCNMicrobiome with two leading voices: Jane Foster from #UTSWMedCenter on Microbiome & Depression and @maburto.bsky.social on Microbiota-Brain Communication

Honoured and delighted to join the board of directors at ALBA Network. I look forward to contributing to the ALBA mission to promote equity and inclusion in neuroscience.
@ucc.ie @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social

Genomics of host–microbiome interactions in humans Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...

Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field.
rdcu.be/epoRR

@blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.

When all this pollution is causing you headaches...

💪🦠

Exciting fundamental discovery!

Early embryos fight bacteria WITHOUT immune cells

Zebrafish, mouse, and human embryos use epithelial cells (trophoectoderm)—not immune cells—to engulf and destroy 𝘌. 𝘤𝘰𝘭𝘪 and 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴

Hoijman Lab Barcelona 🇪🇸
𝘊𝘦𝘭𝘭 𝘏𝘰𝘴𝘵 𝘔𝘪𝘤𝘳𝘰𝘣𝘦

www.sciencedirect.com/science/arti...

Eight Arms to Taste Your Microbiome

This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...

A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain https://www.biorxiv.org/content/10.1101/2025.06.10.658982v1

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome

The microbiome for clinicians Preclinical studies suggest a rapidly growing potential for the application of microbiome research in improving patient outcomes. This perspective lays out the potential steps that can be taken toward...

Microbiome for the clinicians | Cell

www.cell.com/cell/fulltex...

Congratulations to APC's @jatinnagpal.bsky.social, @maburto.bsky.social, Koushika Chandrasekaran, Alexandre Cergneux & @drmoralesgarcia.bsky.social - INSPIRE MSCA who have won the Joint @ucc.ie Research Image of the Year for ‘Brain Pipelines’

Delighted to be awarded the joint @uccresearch.bsky.social image of the year for #zebrafish “Brain Pipelines”!

Great Team Effort - @maburto.bsky.social, @drmoralesgarcia.bsky.social, Koushika and Alex.

@apcmicrobiomeirel.bsky.social, @researchireland.ie, @zebrafishrock.bsky.social

International Booker Prize 2025: Indian author and translators are first to win with a short story collection Banu Mushtaq’s Heart Lamp, translated by Deepa Bhasthi, chronicles the lives of women in southern India

International Booker Prize 2025: Indian author and translators are first to win with a short story collection.

www.irishtimes.com/culture/book...

Grateful and proud to be among the 6 candidates on the ballot for joining the ALBA Network Board of Directors.

🗳️ Please vote and advance ALBA's actions for equity and diversity in neuroscience. Details: www.alba.network/elections

@ucc.ie
@apcmicrobiomeirel.bsky.social
@researchireland.ie