Quick plug for our new resource, the Drosophila Species Stock Exchange. This is a database and mailing list that documents species currently in culture and the labs holding them. If you want to know more or sign up then please get in touch. See attached for more info and please share!
Your work is so well-deserving of this award!! Congrats @tarnopol.bsky.social!
"A world-first gene therapy which turns white blood cells into a disease-busting βliving drugβ has reversed previously untreatable blood cancers." www.positive.news/society/revo...
What do you wish someone had told you before you went on the job market? What actually counts and what doesnβt?
Looking forward to our panel discussion on navigating todayβs job search landscape. Come with questions and hear the unfiltered version of our experiences.
#SciCareers #Academia #ECRs
Epigenome Technologies offers an end-to-end single-cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis
#Epigenetics #SingleCell #PairedTag #Multiomics
bit.ly/3HWFoaw
Great read! Congratulations @katarinazimmer.bsky.social on your insightful @knowablemag.bsky.social piece exploring the remarkable biology of the Aedes aegypti #mosquito knowablemagazine.org/content/arti...
Now that Iβm in chilly and windy Chicago, Iβd never say no to such a warm offer βΊοΈ. Size 7 US
Theyβre beautiful!
Goodbyes are never easy when youβve built a strong community and lifelong friendships. But as they say βWe donβt leave foundations behind, we build upon them.β Onward to the next chapter of my career at UIC, with immense gratitude to @symbionticism.bsky.social for extraordinary mentorship & support!
AI learns from chromatin data to uncover gene interactions www.nature.com/articles/d41...
Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.
In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis π§ͺ Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG
π Save the date!
Such an impactful work showing that the "chromatin fatigue" is real to pose consistent stress for the survival of the cell! Kudos to the team! ππ
Beyond WolbachiaβCan a small molecule control insect reproduction?
Photo of book βThriving as an International Scientistβ written by Sonali Majumdar
This book has never been more timely. Thanks to @sonali-m-19.bsky.social for writing it and for sending me a copy.
Thank you Gopal!
π¨ New pub alert! Check out our latest one that showcases how chemical and genetic innovations can recreate complex hostβsymbiotic interactions in the absence of the symbiont.
www.cell.com/cell-reports...
Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope www.nature.com/articles/s41... #jcampubs
#mustread
Fathers shape embryonic development through molecular βsignaturesβ. Credits: Daniela Velasco/EMBL
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
absolutely wild, from the Small Molecules Considered (SMC) branch:
"...this work provides another piece in a complex biological puzzle aiming to understand the persistent and pervasive nature of ππ°ππ£π’π€π©πͺπ’ endosymbionts." (doi.org/10.1016/j.ce...)
#MicroSky #SymbioSky
This project would not have been possible without @symbionticism.bsky.social and his unwavering support, my undergrad student Mahip Kalra for his relentless troubleshooting efforts that brought the chemical experiments to life, and the incredible Lab team for their timely help every step of the way!
Why does it matter to mimic symbiotic traits?
π It develops symbiont-independent tool kit for insect population control
π It expands symbiont-based biocontrol approaches to species that cannot be stably infected with the bacterium
π Inspires ways to study how epigenetics shape hostβsymbiont biology
Stay tuned for the full banger! Meanwhile, enjoy the commentary on our upcoming pub, where we show that #Wolbachia modify host reproduction via reduced histone acetylationβa fundamental epigenetic process that can be synthetically mimicked by a tiny molecule, even in the absence of Wolbachia!
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years.
www.cell.com/cell-reports...
Jaw dropping!! Beautiful work. Is it live testes culture?
"What you do makes a difference, and you have to decide what kind of difference you want to make"
Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 ΞΌm
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
These awesome microscopy images show what actually happens when E. coli is exposed to an antibiotic.
A bacterium starts to look bumpy as it tries to put more βbricksβ in its defensive wall. But as it builds, it leaves gaps that let the antibiotic to kill it. π§ͺ
www.newscientist.com/article/2498...
Out First Release in @science.org this week:
A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
