Chloé Feltin

My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses.
Interest in evolution, ecology & MGEs is important.
The offer stands until the perfect candidate is found, and it could be you 🫵

🔁 🙏

#microSky #phagesky #UTIsky
@cnrs.fr

🥼 Huge thanks to @clara-inrae.bsky.social @dbszane.bsky.social @sylpiry.bsky.social, all co-authors, and the reviewers for their support, contributions and helpful feedback! 🙏

🚨Our new article is out in #PLOS Pathogens!

What drives nestedness in phages–bacteria interactions network in an agro-ecosystem? 🌱

📖 journals.plos.org/plospathogen...

#Phagesky @inrae-pv.bsky.social @phimresearch.bsky.social @phagedirectory.bsky.social

(Yes, that's a phage in those kinetics!)

The Human Blood Virome Differs in Crohn's Disease The gut microbiota has been strongly associated with Crohn’s disease (CD).1,2 However, this signature becomes blurred when the analysis is restricted to the gut viruses due to intrinsically high inter...

🚨🧬New in Gastroenterology!
What does the blood virome look like?
We show distinct viral signatures in the blood of patients with Crohn’s disease.
🧑‍🔬 Led by Quentin Lamy-Besnier and with Marie-Agnès Petit
www.gastrojournal.org/article/S001...
@sorbonne-universite.fr @inrae-france.bsky.social

🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...

L’Europe autorise son premier additif phagique 🧫🐔 ! Une avancée pour limiter les antibiotiques… mais vigilance : l’histoire pourrait se répéter. #phages #OneHealth @phimresearch.bsky.social @inrae-dpt-spe.bsky.social @sfp-france.bsky.social
www.jle.com/fr/revues/vi...

Early-life temperature drives recruitment success in Eurasian perch (Perca fluviatilis) populations Interannual fluctuations in the abundance of young-of-the-year (YOY) European perch ( Perca fluviatilis ) were studied in two large French peri-alpine lakes. Using a 12-year dataset of late-summer hyd...

New #Preprint on the #Ecology of #PercaFluviatilis is out!

What drives #Perch #Recruitment in #Lakes?

- Surface #Temperature during early development? 🌡️

- Adult #PopulationDynamics? 🐟

- Trophic conditions? 💧

Discover which factor explains 88% of interannual variability 👇
doi.org/10.1101/2025...

Efficient detection and typing of phage-plasmids Phage-plasmids are temperate phages that replicate as plasmids during lysogeny. Despite their high diversity, they carry genes similar to phages and plasmids. This leads to gene exchanges, and to the ...

🚨 New preprint! 🧬

𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect.

We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps:
✅ Accurate
✅ Sensitive
✅ Easy to use

📖 www.biorxiv.org/content/10.1...

We also had an extraordinary session on phage-driven coevolutionary dynamics. Talks by @fredoleroux.bsky.social and her incredible datasets on vibrio phages, phage-plasmids, phage satellites and even phage-plasmid satellites & @clara-inrae.bsky.social on the phageome of apricot trees
#Phagesky

Big thanks to all of my co-authors for making this work possible 🙌 @clara-inrae.bsky.social @dbszane.bsky.social e.bsky.social @sylpiry.bsky.social iry.bsky.social

@inrae-pv.bsky.social @phimresearch.bsky.social sky.social @inrae-dpt-spe.bsky.social sky.social @phagedirectory.bsky.social

Together, we show how #evolutionary history and #ecological ubiquity, more than #local-adaptation, shape phages–bacteria networks in plant-associated environments. 🌱🦠🧬

Both #defence-systems and #prophages contributed to phage resistance.
For one bacterial phylogroup, strains with more defence systems were infected by fewer phages.
Prophages didn’t strictly block infection but seemed to modulate phage efficacy in complex ways.

Both bacterial phylogeny and phage taxonomy influenced the structure of the phage–bacteria interaction network, alongside the observed nestedness.

We tested 23 #phages from diseased #apricot trees against 44 #𝑃𝑠𝑒𝑢𝑑𝑜𝑚𝑜𝑛𝑎𝑠 𝑠𝑦𝑟𝑖𝑛𝑔𝑎𝑒 strains from diseased plants, healthy plants, and nearby habitats. Instead of local adaptation, we found a strongly nested network, reflecting the broad ecological range of 𝑃. 𝑠𝑦𝑟𝑖𝑛𝑔𝑎𝑒.

Ecological ubiquity and phylogeny drive nestedness in phages–bacteria networks and shape the bacterial defensome Identifying the ecological and evolutionary factors that shape phage–bacterial interactions is key to understanding their dynamics in microbial communities. Yet, such interactions remain poorly charac...

New preprint out! 🧬🦠🌱

What shapes #phage–bacteria #networks in #plant environments?
- Ecological origins of bacteria and phages?
- Phage taxonomy?
- Bacterial phylogeny?
- #Prophages? #Defence-systems?

📖 here: www.biorxiv.org/content/10.1...

Discover which of these actually shape the network 👇

Excited 🥳 to share our latest work on gut phages!
Big thanks to @epcrocha.bsky.social, Erick D, Camille d'H, @fplazaonate.bsky.social, Quentin LB, and all others involved for support and contributions! 🙌
Out in Cell Reports @cp-cellreports.bsky.social
doi.org/10.1016/j.ce...
Here's what we found 🤓

Finally on Blue sky ☄️

So proud, grateful, and a bit sentimental as I share this special moment of my thesis defense ! 🦠🧫🌱

A heartfelt thank you to my 3 amazing supervisors @clara-inrae.bsky.social @dbszane.bsky.social @Annette Bérard, and the wonderful defense committee ✨

Congratulations to Dr. Chloé Feltin (still not on Bluesky) on an outstanding PhD defense and her pioneering work on the "Diversity and Interactions of Pseudomonas syringae Phages in Agricultural Environments". #proudPI #phages #Psyringae #INRAE

A Phylogenetic Host‐Range Index Reveals Ecological Constraints in Phage Specialisation and Virulence Phages are typically known for having a limited host range, targeting particular strains within a bacterial species, but accurately measuring their specificity remains challenging. Factors like the g...

After many years in the making, here is our host range #phage paper with #ecology, #evolution and #biocontrol perspectives published in Molecular Ecology! @phimresearch.bsky.social‬ @inrae-pv.bsky.social‬ #PVBMT #JulianGarneau onlinelibrary.wiley.com/doi/10.1111/...
These are our key findings: