Kimberly Luddy

Don't miss this incredible opportunity! Register for IMMUNOLOGY2026™ in Boston, MA today and experience world-class science with the best in the field of #immunology.

🐦‍⬛ Early-bird registration ends March 13: immunology2026.aai.org.

Master complex multiparameter flow cytometry with confidence!

Join our course led by trainer Derek Davies & learn how to design robust experiments, troubleshoot issues & generate reliable data using real immunology examples.

11 & 18 May,

Register now: https://bit.ly/4qip05l

🧬 Have you submitted your abstract for #UKimmunomet26? The deadline is approaching in 3 weeks!

Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.

Find out more & register 🔗 https://bit.ly/493uE45

Cross-priming in cancer immunology and immunotherapy - Nature Reviews Cancer In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

🥳 Our 5th most downloaded #REVIEW in 2025:

Cross-priming in cancer immunology and immunotherapy
#TME #immunotherapy

@NatResCancer
#NRCtop10of2025

Excited to witness the innovation and the mayhem.

Leukemia-driven expansion of ILC3 facilitates a pro-tumoral microenvironment in acute myeloid leukemia #AML @ohiostatemed.bsky.social
www.nature.com/articles/s41...

Double stranded RNA sensing is silenced during early embryonic development @natcomms.nature.com @edinburghup.bsky.social
www.nature.com/articles/s41...

NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...

NSD2 targeting reverses plasticity and drug resistance in prostate cancer

www.nature.com/articles/s41...

There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.

Computational Immunologist - Boston, Massachusetts (US) job with Ragon Institute of MGH, MIT, & Harvard | 12849577 The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen

The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky

www.nature.com/naturecareer...

Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.

Teaching #cancer through a computational lens, integrating cutting edge research with taught components.

Apply below!

www.ucl.ac.uk/prospective-...

Updates to the submission process for LOIs and grants requesting more than $500K in any budget periods. grants.nih.gov/grants/guide...

UKRI opens up grant proposal data to explore using AI to smooth peer review Surging applications has led the UK's main funder to look at ways to reduce the burden on reviewers

UKRI exploring use of AI in grant review - this will prompt debate but interested to know if people think it’d encourage novelty or the opposite? www.chemistryworld.com/news/ukri-op...

The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...

The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery Expanded CAG repeats, the cause of Huntington’s disease, stall replication and reposition to the nuclear periphery to effect repair. Maclay et al. report that the DNA replication checkpoint targets th...

The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery
www.cell.com/cell-reports...

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.

Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...

Lab info: www.oncology.ox.ac.uk/team/jie-yang

Nice writeup of our new @cp-cell.bsky.social article on an intuitive, plain language "grammar" to make simulation modeling of complex multicellular systems more accessible. Huge thx to Forest Ray and @genomeweb.bsky.social !

Joint work by @fertiglab.bsky.social, Genevieve Stein-O'Brien & team! 🧪

Differentiation-associated ISG expression of NK cells in chronic viral infection @cp-iscience.bsky.social
www.cell.com/iscience/ful...

Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...

🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!

This announcement from the NIH is fantastic

“NIH will no longer seek proposals exclusively for animal models”

All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies with human components.

drugdiscoverytrends.com/nih-announces-…

A week away from the start of the @smbmathbiology.bsky.social meeting in #Edmonton so it seems like an apt time to share my convo with conference organizer, Jay Newby. You'll also hear me nerding out about potassium channels in neurons 🧠
smb.org/news/13516785

#SciencePodcast #BiologyInNumbers

Metabolites as agents and targets for cancer immunotherapy  - Nature Reviews Drug Discovery Tumour cells undergo profound changes in their metabolism, but targeting these metabolic pathways requires understanding of the impact on immune cells as well as cancer cells. This Review discusses ho...

Metabolites as agents and targets for cancer immunotherapy www.nature.com/articles/s41...
rdcu.be/etLMD

This new Review discusses the role of metabolic pathways in cancer and immune cells in shaping the tumour microenvironment, and how they can be targeted to improve anticancer immune responses

🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with the BSI #Inflammation Affinity Group on 11–12 Sept in Manchester!

Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July!

☑️ Submit your abstract & register: bit.ly/43q9x9r

Sarah Amend: Describing endocyling in cancer dormancy starts by highlighting the lethality of metastatic + therapy resistant cancer cells.

Guido Ferlazzo: Hepatic stellate cells facilitate the regrowth of dormant cancer cells by reducing NK cell regulation of dormancy in the liver.

Kenneth Pienta: Detecting prostate cancer metastasis with PSMA has changed his understanding of the metastatic cascade.

Day 2 of Cancer Dormancy and Therapy Resistance workshop.