Nathan Lewis

Check out our latest work on inferring metabolite-protein-mediated cell-cell communication. Led by @erickarmingol.bsky.social doi.org/10.1093/bioi...

You should add a few of these photos next time www.google.com/imgres?imgur...

Curious about the rate of change in your exams since face blindness is a thing (~.5-1% of the population with severe fb) and up 10-fold enriched in autism (also elevated in CS student populations). But 10% is quite high.. lol

Download our large database of funding opportunities for early-career faculty and researchers

Download it here: research.jhu.edu/rdt/funding-...

433 funding opportunities.

~1/3 of protein-coding genes are made in the secretory pathway. We curated >1000 of its machinery proteins, opening up new opportunities to engineer cells for drug production, to study cell-cell interactions, or modeling.
@cp-cellsystems.bsky.social paper -> authors.elsevier.com/a/1mFMc8YyDf...

Congrats to Mina Wu for an excellent PhD defense on improving production of mAbs and vaccine proteins by studying protein-protein interactions in the production cells. See doi.org/10.1002/biot... and doi.org/10.1016/j.ym...

I can see this leading to a whole new line of super milk at Whole Foods now...

Got a great score for a vaccine proposal and yet fearful about if it will be funded. Maybe my next proposal will fare better? "Intersectional Bias, Woke Adjuvants, and Inclusive Nanoparticle Vaccines: Disinformation-Resilient Immunity in Trans-genic Mice and Women". Fundable?

Ginkgo Bioworks Awarded Project Agreement Through BARDA's BioMaP-Consortium The goal of the project is to develop novel approaches that strengthen and reduce the costs of domestic mAb biomanufacturing to protect against and treat infection by filoviruses.

Looking forward to this collaboration with Ginkgo www.genengnews.com/topics/biopr...

Monty Python understood p-hacking

😭

I love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning.

Why do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ @JohanRockberg lab. www.pnas.org/doi/abs/10.1...

Robert Francis Kennedy Junior

Robert Francis Kennedy Junior

You mean "bioinformagician"

De novo Design of All-atom Biomolecular Interactions with RFdiffusion3 Deep learning has accelerated protein design, but most existing methods are restricted to generating protein backbone coordinates and often neglect interactions with other biomolecules. We present RFd...

The team at BioF:GREAT is always on the lookout for new protein design models that care about more than just the backbone! We are excited to try the new RFdiffusion3 (RFD3)! 🚀 New preprint from David Baker!🚀 🧪 #ProteinDesign #DeepLearning #ComputationalBiology

www.biorxiv.org/content/10.1...

Mapping Out the “Everything” of Protein Secretion The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.

Honored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at GEN www.genengnews.com/topics/biopr...

Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity - npj Vaccines npj Vaccines - Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime www.nature.com/articles/s41...

SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx | mBio Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019, can infect the gastrointestinal (GI) tract, and individuals who exhibit GI symptoms of...

While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now.
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime
journals.asm.org/doi/10.1128/...

Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu

With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.

🚨 Join us for the next GlyGen Webinar!

🗓 Feb 4, 2025 | 🕒 10 AM EST

🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social

💡 Research, Collaboration, Service & Training at CCRC

📑 Details: wiki.glygen.org

Also, don't miss our Jan webinar on Jan 28th!

#glycotime

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...

After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!

www.nature.com/articles/s42...

#science #biotech #cancermetabolism
Thread below:

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells Nature Metabolism - Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase...

Here's a link to the pdf: rdcu.be/d6aZw

Genetic Tweak Optimizes Drug-making Cells by Blocking Buildup of Toxic Byproduct Scientists led by UC San Diego have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for t...

today.ucsd.edu/story/geneti...

I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...

a cartoon of a pitcher with a spoon and a cup of sugar on a table ALT: a cartoon of a pitcher with a spoon and a cup of sugar on a table

Calling all glyco-enthusiasts!! We have an opening for a tenure-track faculty member at any rank in the Complex Carbohydrate Research Center (ccrc.uga.edu) in the areas of plant or microbial glycoscience. Come join our amazing team.
#glycotime
www.ugajobsearch.com/postings/400...

These past few years have seen a rapid expansion of cell-cell communication research. Check out our new review of the diverse methods leveraging single-cell and spatial omics: rdcu.be/dwkND