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Penny Shockett

@pshockett

Immunologist/Molecular Biologist & Biology Professor. Likes running and furry friends.

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27.10.2023
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Latest posts by Penny Shockett @pshockett

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Derek Davis on Instagram: "Faisel R. Khan @frk_nc addresses a large crowd in Portland, Maine this afternoon, just one of many demonstrations against ICE and Trump across the U.S. on Friday." 7,031 likes, 107 comments - derekeldavis on January 30, 2026: "Faisel R. Khan @frk_nc addresses a large crowd in Portland, Maine this afternoon, just one of many demonstrations against ICE and Trump a...

www.instagram.com/reel/DUJoIyE...

01.02.2026 01:25 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Recombination between fragile regions associated with chromosomal rearrangements in glioblastoma can be mediated by RAGs - PubMed The RAGs, comprising RAG1 and RAG2, catalyze V(D)J recombination by recognizing recombination-signal sequences (RSS). Glioblastoma, the aggressive brain cancer, has many oncogenic chromosomal alterations; however, the mechanism of their generation is largely unknown. Here, we report that RAGs are ex โ€ฆ

pubmed.ncbi.nlm.nih.gov/41362770/

03.01.2026 15:07 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Ladies and Gentleman..

I give you โ€ฆ

Raaaandy Rainbow ๐ŸŒˆ

HHS..๐Ÿ–•๐Ÿป

Enjoyโ€ฆ
#SheShed

04.12.2025 16:03 ๐Ÿ‘ 1033 ๐Ÿ” 445 ๐Ÿ’ฌ 42 ๐Ÿ“Œ 23
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In todayโ€™s Substack, authored by Dr. Aimee Pugh Bernard, PhD, in partnership with Immunology Explained, an initiative of The American Association of Immunologists (AAI), we unpack one of the mostโ€ฆ | U... In todayโ€™s Substack, authored by Dr. Aimee Pugh Bernard, PhD, in partnership with Immunology Explained, an initiative of The American Association of Immunologists (AAI), we unpack one of the most comm...

"Vaccine Immunity vs. Infection Out in the Wild" pass it on.
www.linkedin.com/posts/unbias...

07.11.2025 13:32 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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NIH Institute Director Abruptly Replaced New NIEHS chief is a friend of Vice President JD Vance

NIH Institute Director Abruptly Replaced www.medpagetoday.com/washington-w...

24.10.2025 22:47 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Dismantling the Institutional Review Board (IRB), that oversees all human subjects research, is bad. Really bad.

19.10.2025 16:00 ๐Ÿ‘ 1716 ๐Ÿ” 730 ๐Ÿ’ฌ 22 ๐Ÿ“Œ 50
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Home - Immunology Explained Understand how your immune system works with clear, science-backed insights. We empower you to make informed decisions and feel confident about your health.

Bluesky
๐Ÿงฌ Do you know how your immune system works every day?

Immunology Explained, a new initiative from the @aai.org, makes it simple to understand how it impacts everyday health with clear, science-backed info.

Check it out: immunologyexplained.aai.org

#ImmunologyExplained#ImmuneSystem#Science

08.10.2025 12:20 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Iโ€™m a physician who has looked at hundreds of studies of vaccine safety, and hereโ€™s some of what RFK Jr. gets wrong The health secretary has made many inaccurate statements about vaccines. But the science is clear that vaccines have dramatically reduced childhood illness, disability and death.

Iโ€™m a physician who has looked at hundreds of studies of vaccine safety, and hereโ€™s some of what RFK Jr. gets wrong

by @jakescottmd.bsky.social (congrats Jake - keep it up!)

theconversation.com/im-a-physici...

26.06.2025 13:18 ๐Ÿ‘ 127 ๐Ÿ” 62 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 6
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Targeting Gluten: Researchers Delete Proteins in Wheat Harmful to People with Celiac Disease A UC Davis study found that deleting a cluster of genes in wheat may reduce wheat allergies without harming breadmaking.

๐ŸŒฑ From UC Davis: Deleting key gliadin genes boosts wheat gluten strength & cuts celiac-triggering epitopesโ€”without harming yield. (Maria Rottersman, Jorge Dubcovsky)
โ–ถ๏ธ www.ucdavis.edu/food/news/ta...

05.05.2025 16:23 ๐Ÿ‘ 41 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2
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Malaria-Driven Cancer: How Plasmodium falciparum Triggers Burkitt Lymphoma in Children | Immunopaedia A recent study published has revealed the molecular link between malaria infection and Burkitt lymphoma (BL)...

#ImmunologyNews A recent study published has revealed the molecular link between malaria infection and Burkitt lymphoma (BL)โ€ฆ #immunology #research

Read more here:
www.immunopaedia.org.za/breaking-new...

07.05.2025 13:07 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Intestinal mucosal immune responses induced by novel oralย poliovirus vaccine type 2ย and Sabin monovalent oral poliovirusย vaccine type 2: an analysis of data from four clinical trials We found no evidence of differences in the intestinal mucosal immune responses induced by nOPV2 orย Sabin mOPV2 and observed the strongest responses in infants.

This is good news.

Comparable immune responses (IgA & neutralising antibodies) with new oral polio vaccine compared to Sabin vaccine - hopefully can help interrupt circulating vaccine-derived poliovirus outbreaks.
@lancetmicrobe.bsky.social

#IDSky #ImmunoSky
www.thelancet.com/journals/lan...

05.05.2025 17:02 ๐Ÿ‘ 13 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Now it's your fault if you get sick?
Dr. Oz: 'It's your patriotic duty to take care of yourself. Healthy people don't consume healthcare resources.'

19.04.2025 15:41 ๐Ÿ‘ 2774 ๐Ÿ” 755 ๐Ÿ’ฌ 786 ๐Ÿ“Œ 926
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Environmental Contaminants: Effects of a Changing Climate on Human Health Human activity releases pollutants into the air, water, and soil. Environmental contaminants do not merely contribute to climate change, but they also have a profound impact on human health.

reference.medscape.com/slideshow/en...

18.04.2025 12:44 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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The CDC Buried a Measles Forecast That Stressed the Need for Vaccinations The move โ€” along with the CDCโ€™s explanation โ€” is a sign that the nationโ€™s top public health agency may be falling in line under HHS Secretary Robert F. Kennedy Jr., a longtime critic of vaccines.

The CDC Buried a Measles Forecast That Stressed the Need for Vaccinations
www.propublica.org/article/meas...

31.03.2025 23:00 ๐Ÿ‘ 206 ๐Ÿ” 65 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 2
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Two infants die of whooping cough in Louisiana as national case numbers climb | CNN There have been 6,600 pertussis cases reported in the US in 2025, almost four times the number at this point last year.

Bringing back all the greatest hits. ๐Ÿ˜ฅ

03.04.2025 12:05 ๐Ÿ‘ 494 ๐Ÿ” 218 ๐Ÿ’ฌ 30 ๐Ÿ“Œ 15
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Threats to public health at every angle Covid anniversary, pandemic revisionism, chronic diseases, and a boulder going down the hill

yourlocalepidemiologist.substack.com/p/threats-to...

28.03.2025 14:12 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

We are in the midst of what many consider the most promising pancreatic cancer cure research in decades. This is literally joining the War on Cancer on the side of cancer. It's happening in multiple departments. They're also attacking mRNA fax science which is the heart of the possible breakthrough.

26.03.2025 16:45 ๐Ÿ‘ 6764 ๐Ÿ” 2362 ๐Ÿ’ฌ 124 ๐Ÿ“Œ 108

This is just horrible.

The FY25 CR obliterates the already small funding allocations for the development of new treatments for patients with pancreatic cancer, lung cancer and glioblastoma.... for what purpose?

These are three of the deadliest types of cancer.

27.03.2025 11:26 ๐Ÿ‘ 60 ๐Ÿ” 36 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
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H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article) Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.

"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q

26.03.2025 21:57 ๐Ÿ‘ 1304 ๐Ÿ” 726 ๐Ÿ’ฌ 60 ๐Ÿ“Œ 65

The US invited Rumesya Ozturk to study at Tufts on a Fulbright, a program that promotes "mutual understanding" between America and the world.

As a Fulbrighter, this video makes me ill. We certainly aren't promoting mutual understanding.

We're promoting the idea that dissent is not welcome here.

26.03.2025 17:58 ๐Ÿ‘ 359 ๐Ÿ” 111 ๐Ÿ’ฌ 17 ๐Ÿ“Œ 7

14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"๐Ÿงช 1/n
taggs.hhs.gov/Content/Data...

26.03.2025 15:38 ๐Ÿ‘ 684 ๐Ÿ” 345 ๐Ÿ’ฌ 22 ๐Ÿ“Œ 21
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H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.

โ€œThe cancellations stunned scientists who had depended on the governmentโ€™s support.
โ€œThe idea that we donโ€™t need further research to learn how to treat health problems caused by coronaviruses and prevent future pandemics because โ€˜Covid-19 is overโ€™ is absurd,โ€ said Pamela Bjorkmanโ€

26.03.2025 23:54 ๐Ÿ‘ 41 ๐Ÿ” 27 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 6
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โ€˜Chaos and Confusionโ€™ at the N.I.H., the Crown Jewel of American Science Senior scientists at the National Institutes of Health fear that research on conditions like obesity, heart disease and cancer will be undermined by President Trumpโ€™s policies.

โ€˜Chaos and Confusionโ€™ at the Crown Jewel of American Science

Senior scientists at the National Institutes of Health fear that research on conditions like obesity, heart disease and cancer will be undermined by President Trumpโ€™s policies.

www.nytimes.com/2025...
1/4

24.03.2025 12:49 ๐Ÿ‘ 28 ๐Ÿ” 16 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 3
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Dynamic STING repression orchestrates immune cell development and function Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

'Neutrophils expressed notably low levels of STING, whereas forced expression led to uncontrolled systemic inflammation. During development in the thymus, Tcells dynamically & epigenetically restricted STING expression through DNMT1โ€“mediated transcriptional silencing'
#Immunology

20.03.2025 09:18 ๐Ÿ‘ 18 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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GM-CSFโ€“mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

#Medsky๐Ÿงช #IDsky #immunosky #publichealth During #mold infections, crosstalk between ๐Ÿซ epithelial cells & fungicidal #neutrophils via GM-CSF improves survival, according to a new study in ๐Ÿ @sciimmunology.bsky.social

www.science.org/doi/10.1126/...

21.03.2025 18:35 ๐Ÿ‘ 19 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Understanding measles virus: from isolation to immunological cellular mechanisms and immunisation 1954โ€“2024 Measles virus (Morbillivirus abbreviated as MV, but more recently MeV) is the causal agent of measles disease, thought to have existed at least 4,000 years ago, affecting predominantly infants, but

#Medsky๐Ÿงช#IDsky #immunosky #pedsky #publichealth #measles-induced
#immuneamnesia that leads to the loss of immune memory cells, resulting in excess non-measles โ€ฆ
www.mdpi.com/2076-393X/13...

www.explorationpub.com/Journals/ei/...

www.jmidonline.org/index.php?mn...

www.nature.com/articles/s41...

23.03.2025 06:14 ๐Ÿ‘ 16 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Immune Amnesia: How the Texas Measles Outbreak Could Promote the Spread of Other Infectious Diseases The measles virus attacks long-lived immune cells, reducing antibody-mediated protection from other infectious diseases and casting a long shadow of childhood mortality.

journals.asm.org/doi/full/10....

www.sciencedirect.com/science/arti...

Measles outbreak in ๐Ÿ‡บ๐Ÿ‡ธ & The Side Effects of Misinformation that made it more dangerous & deadly

www.the-scientist.com/immune-amnes...

23.03.2025 06:18 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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A physical wiring diagram for the human immune system - Nature Systematic measurements of the interactions between proteins found on the surfaces of human leukocytes provides a global view of the way that immune cells are dynamically connected by recept...

yelling at clouds for a second- I wish that at some point in the vaccine design project we would take the antigens and do this, especially for virus entry glycoproteins:

23.03.2025 04:34 ๐Ÿ‘ 66 ๐Ÿ” 19 ๐Ÿ’ฌ 11 ๐Ÿ“Œ 3

there are forbidden words across the sciences

chromosome โ€œorientationโ€ and โ€œsegregationโ€
gene โ€œexpressionโ€
mucosal โ€œbarrierโ€
microbial โ€œdiversityโ€

itโ€™s not an accident, or a coincidence IMO

itโ€™s intentionally overbroad and disruptive to thought professionals

10.03.2025 11:57 ๐Ÿ‘ 26 ๐Ÿ” 9 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 0
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Tardigrade Protein Protects Healthy Cells from Radiation Damage This approach could transform radiation therapy by allowing higher doses to be used more safely, ultimately improving outcomes for cancer patients.

Tardigrade Protein Protects Healthy Cells from Radiation Damage

www.genengnews.com/topics/cance...

02.03.2025 21:15 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0