Ilaria Bellantuono

New NIH research shows even 15 minutes of brisk walking a day can reduce risks of multiple age-related diseases in adults 60+.
pubmed.ncbi.nlm.nih.gov/29402653/

At AGE, we’re committed to advancing science that extends healthspan.

#HealthyAging #Healthspan

Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context...

Even if the message try to be positive I am not sure there is much reason to be onlinelibrary.wiley.com/doi/full/10....

The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study Accelerated biological aging (KDM-BA/PhenoAge) predicts higher multimorbidity risks and 5.3–7.0 life-years lost in 332,012 UK adults. Those with accelerated aging face 12%–37% increased transition ri...

This is the first evidence I see that accelerated biological ageing increased risk of multimorbidity doi.org/10.1111/acel...

In case you missed our news yesterday...we have funded five places for our Academy members on Zinc's upcoming Inflection Fellowship Programme for mid-career professionals. More info here: vivensafoundation.org.uk/news/five-fu...
#midcareeropportunity #FundingForAgeingWell

Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries - Nature Medicine In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-life factors rather than neuroprotective effects in aging.

Education boosts memory and brain volume in aging but doesn't shield against cognitive decline, suggesting early-life factors are key.

by Fjell AM, Rogeberg O (...) Vidal-Piñeiro D et 20 al. in Nat Med #MedSky

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Lithium deficiency and the onset of Alzheimer’s disease - Nature Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease

go.nature.com/4ftdsb2

TERT (telomerase) can regulate physiological levels of inflammatory signals independently of its catalytic functions
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.

A wearable sensor that measures multiple hormones simultaneously in sweat to provide continuous real-time metrics and dynamics of stress
www.science.org/doi/10.1126/...

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Break the selective silence on the genocide in Gaza Substantial and well-documented evidence indicates a catastrophic public health emergency in Gaza (appendix pp 1–5), marked by severe food insecurity and alarming levels of malnutrition-related deaths...

Break the selective silence on the #genocide in #Gaza.

"...Silence is not an option..."

#Palestine #EthnicCleansing #Israel #Humanitarian

www.thelancet.com/journals/lan...

Dietary patterns and accelerated multimorbidity in older adults - Nature Aging In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...

A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults
www.nature.com/articles/s43...

A geroscience response to cancellation of the UK’s Medicines Repurposing Programme: challenges and opportunities After just 4 years of operation, the discontinuation of the UK’s Medicines Repurposing Programme in April, 2025,1 marks a concerning shift in drug development—particularly for geroscience. The program...

Happy to share our response to the cancellation of the UK’s Medicines repurposing programme and the implication for geroscience www.thelancet.com/journals/lan... @nikrat.bsky.social

a yellow sign that says we 're hiring ALT: a yellow sign that says we 're hiring

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.

jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/

Ageing accelerates around age 50 ― some organs faster than others An analysis of how various tissues age is the latest to suggest that ageing does not march to a steady beat.

An analysis of how various tissues age is the latest to suggest that ageing does not march to a steady beat.

go.nature.com/4lVWZ1t

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...

Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor...

What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes?
The largest, systematic review of 57 studies, 35 cohorts.
7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps
thelancet.com/journals/lan...

Accelerated brain ageing during the COVID-19 pandemic - Nature Communications This study shows that the COVID-19 pandemic accelerated brain ageing in UK adults, even without infection. The effect was stronger in older individuals, in men, and those from deprived backgrounds. Co...

This is not surprising considering previous studies in mice. The real worry is that this is not just confined to the brain and we are heading for a sharp increase in #multimorbidity and #frailty in 10-15 years in a much younger population for which we are unprepared www.nature.com/articles/s41...

How sugar overload in early life affects the brain later A study in mice finds that a high-sucrose diet during youth has long-term implications for learning and brain connectivity.

A sugary diet in early life rewires the brains of mice, affecting their learning as adults

go.nature.com/4lAjFnZ

A gut microbiome metabolite promotes atherosclerosis by hijacking the immune system
@nature.com
nature.com/articles/s41...
www.nature.com/articles/d41...

Why do ageing rates vary by country? Massive study says politics play a part Social inequality and the decay of democratic institutions are linked to accelerated ageing — but education seems to slow the process.

Social inequality and weak democratic institutions are linked to faster ageing

go.nature.com/44KplEp

Firma la petizione Chiediamo la Nomina di Francesca Albanese al Premio Nobel per la Pace

Chiediamo la Nomina di Francesca #Albanese al Premio #Nobel per la #Pace

#Genocidio #Israele #Palestina #PuliziaEtnica

chng.it/Dq5NH4sj6D

Workouts can help gut microbes to quell cancer Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate

go.nature.com/4lIZx2m

New Anti-Aging Evidence For Estrogen Organ Clocks Add to the Benefits of Replacement After Menopause

On the first report of estrogen slowing the pace of aging of the immune system, with the background of flawed and misinterpreted clinical trials of hormone replacement therapy
erictopol.substack.com/p/new-anti-a...

Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...

Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age Human skin fibroblasts in vitro preserve the memory of age and health.

onlinelibrary.wiley.com/doi/full/10....

Delighted to be giving evidence to the Science Innovation and Technology select committee on the potential and barriers of geroprotectors for frailty. Thank you to the Committee for their interests and thoughtful questions

Nonuniversality of inflammaging across human populations - Nature Aging Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...

www.nature.com/articles/s43...

How to speed up peer review: make applicants mark one another ‘Distributed peer review’ of grants makes process more than twice as fast — and includes some cheat-prevention measures.

An experimental peer-review system more than halves the time taken to review grant applications

https://go.nature.com/46lASfN

Updating the risks of sugar sweetened beverages, processed meat and trans fatty acids for Type 2 diabetes, colon cancer and heart disease @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...