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🗞️Un estudi liderat per @pilardomingoc.bsky.social , professora de la Facultat, i @celiaferriolg.bsky.social , doctoranda en Biodiversitat i Biologia Evolutiva, revela com certs virus evolucionen i s’adapten per a infectar nous bacteris.
🔗Més informació:
My @i2sysbio.es colleagues Lucas Mora, Rafael Sanjuan @rafa-sanjuan.bsky.social and Pilar Domingo Calap @pilardomingoc.bsky.social published a paper about reversible phenotypic resistance to phages in Klebsiella. 👏👏 Congratulations! 🧬🖥🧪🦠🧫 #microsky #viruses #phages
www.cell.com/iscience/ful...
My @i2sysbio.es colleague Pilar Domingo-Calap @pilardomingoc.bsky.social speaking at the Pangenome congress in Valencia 🇪🇸 about the success of the personalized #phage therapy achieved by her company Evolving Therapeutics and phage experimental evolution done in her lab 👏👏👏
#microsky #viruses 🧬🖥🧪🦠🧫
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Very proud of @celiaferriolg.bsky.social! Amazing experimental evolution for phage optimization and for host range expansion, allowing us to understand the evolvability of phage RBPs. This work is part of her PhD project at the #EnBivirLab @i2sysbio.es @uv.es @ccbiologiquesuv.bsky.social
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
👉 EVOLVING THERAPEUTICS, s'encarrega de la prevenció, diagnòstic i tractament de bacteris patògens resistents a antibiòtics amb una metodologia basada en fags. Cofundada i dirigida per @pilardomingoc.bsky.social , exalumna i professora de la Facultat.
▶️ go.uv.es/Is1CpTJ
Per finalitzar l' Inoovation Stage de #VDS, tots els participants pujen per fer una #taularodona.
🌀Envolving Therapeutics, spin-off de @ccbiologiquesuv.bsky.social al #VDS com a empresa del Parc Científic.
👩🏼🔬 @pilardomingoc.bsky.social , exalumna de @ccbiologiquesuv.bsky.social i actual professora, dóna a conèixer la seu empresa, Envolving Therapeutics, al Innovation Stage de #VDS.
🎉👏 #I2SysBio (@uv.es - @csic.es) researchers Rafael Sanjuán, Andrés Moya and @pilardomingoc.bsky.social are included in Stanford University's Word Ranking Scientists. This ranking recognises the top 2% of authors worldwide for the excellence of their intellectual output.
www.uv.es/uvweb/biolog...
Thanks!!
Thanks!!
Gracias!!
Proud to be included in the top 2% World Ranking of Scientist @stanforduniversity.bsky.social, and to be the only woman at my Faculty in 2024 @ccbiologiquesuv.bsky.social. Thanks to my lab #EnBiVirLab @i2sysbio.es @uv.es @csic.es, all collaborators, and special thanks to all #VLCPhageHunters!
📰Investigadors de l'I² SysBio desenrotllen una IA pionera per a predir l'acció dels fags contra bacteris.
🖇️Més informació: links.uv.es/4plKymq
#UVCiència @beatrizbeamud.bsky.social @pilardomingoc.bsky.social @rafa-sanjuan.bsky.social @i2sysbio.es @uv.es
www.uv.es/uvweb/unitat...
👩🔬La investigadora del #I2SysBio (@uv.es-@csic.es) @pilardomingoc.bsky.social ha sido propuesta por la revista Magas de @elespanol.com para formar parte del Top 100 Mujeres Líderes.
🔗Te invitamos a leer su propuesta y votarla.
💜¡Enhorabuena, Pilar!
www.elespanol.com/mujer/lastop...
Una paciente con fibrosis quística e infección crónica causada por P. aeruginosa supera un rechazo agudo de trasplante pulmonar gracias a una terapia basada en la combinación de fagos, inmunosupresores y antibióticos. Estudio liderado por @pilardomingoc.bsky.social
elpais.com/ciencia/2025...
Thanks Maria!!
A patient with cystic fibrosis overcomes rejection of lung transplant through phage therapy! My colleagues from @i2sysbio.es led by Pilar Domingo Calap @pilardomingoc.bsky.social are saving patients' lives with phages. Truly admirable! 👏
www.i2sysbio.es/communicatio...
#microsky #phages #viruses 🧪🦠🧫
Thanks!!
Great job by the brilliant @pilardomingoc.bsky.social and her team!
Gracias!!! Mucho esfuerzo que se ve recompensado!
A patient with cystic fibrosis overcomes acute rejection of lung transplant through phage therapy www.i2sysbio.es/communicatio... bravo @pilardomingoc.bsky.social 👏
✍️ Vos deixem per ací l'article sobre els fags que va escriure per a Mètode en el número 112: «Els virus dels bacteris» 🦠
#UV | 🔬Una pacient amb fibrosi quística supera amb teràpia de fags el rebuig agut del seu trasplantament pulmonar
ℹ️ Més info i accés a l'article complet:
