@matthew-batisio
Cellular Structural Biology Wellcome DPhil Student at The University of Oxford. Working in Peijun Zhang’s lab at The Oxford Division of Structural Biology. Passionate about biomedical animation and science communication: Batisio.co.uk
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
🚨New paper! 🚨
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.
These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?
www.cell.com/iscience/ful...
@cp-iscience.bsky.social
🧵THREAD🧵
Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪
Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42...
To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
The latest from RNA-designer extraordinaire
@monari-luca.bsky.social is out in @natcomms.nature.com. We introduce PyFuRNAce.de, a design tool for RNA origami. It simplifies design with a rich motif library and automatic 2d/3d modeling and routing optimization 🧬
www.nature.com/articles/s41...
Is it possible to engineer new cellular life from the bottom up?
The Göpfrich group @kgoepfrich.bsky.social @mpi-mr.bsky.social have designed an RNA origami nanotube 🟡 to mimic the cytoskeleton:
www.nature.com/articles/s41...
It was a fun challenge to animate T7 RNA polymerase 🔵
#blender #b3d
Incredible animation! Well done everyone
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Computer generated graphics of a DNA structure from the movie Prometheus
Close up of the Prometheus DNA molecule being swallowed up by black goo.
I watched the Alien Prometheus movie recently and the opening scene had some pretty funky DNA
✅ Left-handed double helix
✅ Extreme 🔥 grooves
✅ ~15 bases per turn
✅ Super-glued base ladder
✅ Subatomic black goo
What are some of your favourite funny molecule structures from TV/movies?
Thank you @bradyajohnston.bsky.social for creating #molecularnodes for #blender3d, making PDB file import and showing different protein representations a lot smoother.
How do trypanosomes evolve resistance to sleeping sickness drugs?
Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell.
It was a pleasure to create this animation for Simone Weyand.
Read more here: elifesciences.org/reviewed-pre...
#blender #b3d #animation #science
Missed the 2025 Next Generation Biophysics Symposium?
Great news – you can now watch the fantastic talks on our YouTube channel!
www.youtube.com/playlist?lis...
Don't miss these great discussions on how new and emerging technologies may be able to address challenging biological questions.
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
SynapseNet is a deep learning based software tool that automates the segmentation of vesicles, mitochondria, synaptic compartments, and the active zone. This is visualized in three panels. On the left, a section of an electron tomogram with a synaptic compartment densely filled with vesicles, which appear as round structures with dark boundary and light body in the image, is shwon. The top right panel shows the segmentation result of vesicles, visualized by masks with an individual color per vesicle and outlines for the segmented compartment (red) and active zone (blue). The bottom right panels shows a 3D rendering of the segmentation with vesicles shown as yellow spheres.
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
New online: Molecular basis for the activation of outer dynein arms in cilia
We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.
Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM
Ensemble model of the full length Pex5 receptor (different blue color) in complex with Pex8 (green colors). Key Findings: Pex8 binds to a novel site on the mostly unfolded N-terminal region of the Pex5 receptor. This interaction is essential for peroxisomal protein import. Computational modelling reveals the formation of an assembly with the trimeric peroxisomal E3-ubiquitin ligase. We propose that this action positions the Pex5 receptor for its recycling, a step essential for the entire protein import process. Why this matters: Peroxisomes rely entirely on the import of folded proteins to function. Impaired peroxisome function is linked to severe disorders, and recent data show their crucial roles in carcinogenesis and the immune response. Our work elevates Pex8 from an enigma to a central player in this critical biological process. Read the full story and see the structures here: https://www.biorxiv.org/content/10.1101/2025.08.30.673231v1 #CellBiology #StructuralBiology #Peroxisome #ProteinImport #bioRxiv #Biochemistry
We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.
Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Stunning cryo-ET from Peijun Zhang lab: Direct visualization of HIV-1 nuclear import!
Hundreds of viral cores captured entering the nucleus. The NPC dilates to let the capsid through. A masterclass in correlative microscopy that makes it quantitative. A leap for structural virology! @emboreports.org
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
