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Gina DeNicola

@ginadenicola

Redox biology and cancer metabolism @ Moffitt Cancer Center. Views my own.

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08.08.2023
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Latest posts by Gina DeNicola @ginadenicola

Congratulations Joanne!

28.02.2026 21:41 ๐Ÿ‘ 5 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

It is. I saw the pizza you posted earlier this week and immediately ordered a large pizza that I have been rationing all week. Last piece will be eaten today ๐Ÿ˜‹

27.02.2026 14:26 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Second session at #CFM_MetCanc on the relationship between exercise, nutritional signals and cancer prevention.

Speakers:ย 
Mark Febbraio,ย @monashuniversity.bsky.socialย 
Gina DeNicola @ginadenicola.bsky.social,ย  Moffit Cancer Center

โœ๏ธ bit.ly/45jaORuย 

Sponsored by @caixaresearch.bsky.social

17.02.2026 10:07 ๐Ÿ‘ 3 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Best practices for cysteine analysis Accurate measurement of cysteine and related thiol-containing metabolites is essential for understanding cellular redox regulation. However, the intrinsic reactivity and instability of cysteine presen...

Very helpful methods and protocol! www.sciexplor.com/articles/fos...

Great work @ginadenicola.bsky.social and team!

01.02.2026 19:24 ๐Ÿ‘ 4 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Excited to announce that registration is officially open for #METPHYS2026!

All meeting details can be found here:
www.sablesys.com/metphys-the-...

13.01.2026 16:12 ๐Ÿ‘ 14 ๐Ÿ” 13 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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A simple, anesthesia-free infusion technique for in vivo metabolic tracing Accurate metabolic flux analysis requires tracer delivery that preserves physiological metabolism. Current methods may distort metabolism through anesthesia, surgical stress, or complex procedures. We...

A practical, anesthesia-free platform for in vivo metabolic tracing! Preprint: doi.org/10.64898/202.... Questions? Reach outโ€”happy to share protocols!

06.01.2026 20:11 ๐Ÿ‘ 9 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Key advantages: โœ… Minimal anesthesia โœ… Physiological metabolite pools โœ… Mice move freely โœ… No surgical expertise needed โœ… Steady-state labeling comparable to jugular infusion.

06.01.2026 20:11 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Using UยนยณCโ‚†-cystine infusion, we show tail vein achieves robust steady-state labeling of cystine and downstream metabolites (glutathione, taurine pathways) without the supraphysiologic tracer accumulation seen with jugular infusion.

06.01.2026 20:11 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A schematic depicting the tail vein catheter procedure.

A schematic depicting the tail vein catheter procedure.

Our solution is a tail vein catheter that can be implanted in just 5-10 min under brief anesthesia (vs 30-40 min jugular surgery). We secure the catheter and thread the tubing subcutaneously into a harness system. Mice can be infused awake. No surgery, no recovery, no analgesics needed!

06.01.2026 20:11 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A volcano plot showing metabolic changes in serum of mice exposed to isofluorane anesthesia compared to control conditions.

A volcano plot showing metabolic changes in serum of mice exposed to isofluorane anesthesia compared to control conditions.

YES! Just 2 hours of isoflurane profoundly altered metabolism. Glycolysis/TCA โ†“, sulfur amino acids โ†“, acylcarnitines โ†“, while BCAAs โ†‘, ketones โ†‘, fatty acids โ†‘โ€”suggesting complex metabolic deregulation. These pool size changes compromise flux interpretation.

06.01.2026 20:11 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

This project started when our jugular surgeon left research. After initial panic, we wondered โ€œcan we use the tail vein?โ€ But we would need anesthesia, is it really that bad for metabolism?

06.01.2026 20:11 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. ๐Ÿงต

06.01.2026 20:11 ๐Ÿ‘ 17 ๐Ÿ” 10 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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Got up at 5AM today to do the Miles for Moffitt 10K with Basma from my lab. Success!

23.11.2025 00:33 ๐Ÿ‘ 16 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Exciting!

12.11.2025 16:38 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

The best compliment ๐Ÿ˜

24.09.2025 18:19 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Open Rank, Tenure Track Position โ€“ Metabolic Physiology - Salt Lake City, Utah job with University of Utah, Department of Nutrition & Integrative Physiology | 12844064 The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share!
@uofunuip.bsky.social

27.08.2025 23:05 ๐Ÿ‘ 23 ๐Ÿ” 27 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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W1TTW2 Professorship in Membrane Biology (m/f/d)

Job alert ๐Ÿ“ฃ Our faculty looks for a Junior Professor W1 with tt to W2 in Membrane Biology! We are looking for #ECRs working on membrane biogenesis,contact sites,composition & other aspects of membranes in ๐ŸŒฑ and other organisms! DM me if you need more details!

jobs.ruhr-uni-bochum.de/jobposting/f...

22.08.2025 13:47 ๐Ÿ‘ 33 ๐Ÿ” 60 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social

27.08.2025 20:50 ๐Ÿ‘ 67 ๐Ÿ” 77 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 4

A wonderful new opportunity - for both Rising Stars and established Research Leaders - to open a research lab in Ireland ๐Ÿ‡ฎ๐Ÿ‡ช๐Ÿงช

Up to 3.25 million euro in support ๐Ÿคฉ

#GlobalTalentIreland #Research #Ireland

21.08.2025 14:45 ๐Ÿ‘ 8 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

18.08.2025 07:45 ๐Ÿ‘ 51 ๐Ÿ” 56 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Open Rank, Tenure Track Position โ€“ Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355 The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

21.07.2025 19:25 ๐Ÿ‘ 29 ๐Ÿ” 32 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance... Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...

12.08.2025 13:11 ๐Ÿ‘ 7 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Canโ€™t wait for the next one! @olzmannlab.bsky.social

31.07.2025 18:42 ๐Ÿ‘ 27 ๐Ÿ” 9 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Hot science and hot temperatures at the FASEB Ferroptosis conference start tonight. Seriously the highs are 110F here ๐Ÿฅต but it's beautiful!

27.07.2025 15:35 ๐Ÿ‘ 14 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! โœจ

24.07.2025 19:13 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! ๐Ÿ˜ƒ

22.07.2025 19:55 ๐Ÿ‘ 27 ๐Ÿ” 11 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2

IMPORTANT IMPORTANT IMPORTANT IMPORTANT

Please watch the workshop video and COMMENT by 5:00 Monday 7/14

This is the source of the "no more model organism only grants in NIH-funded research" decree.

12.07.2025 00:11 ๐Ÿ‘ 103 ๐Ÿ” 115 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 12

New work from @karrethlab.bsky.social!

10.06.2025 11:55 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

FRA1 drives melanoma metastasis through an actionable transcriptional network https://www.biorxiv.org/content/10.1101/2025.06.07.658418v1

10.06.2025 11:49 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress respon...

Unravelling cysteine-deficiency-associated rapid weight loss

www.nature.com/articles/s41...

21.05.2025 16:25 ๐Ÿ‘ 15 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1