Ron Geller

Out today in @natecoevo.nature.com!

📝 www.nature.com/articles/s41...

We compare the mutational tolerance of enteroviruses A & B across their full proteomes, mapping distinct host interaction strategies 🦠 and identifying mutation-resistant regions that could inform antiviral development 💊

Un comentario sobre nuestra ultima publicación.

Final version just came out in Nature Ecology and Evolution. www.nature.com/articles/s41...

An Evolutionary Story of Agency

🧪🧬 'An Evolutionary Story of Agency', an #OpenAccess book, exposes the role of "agency" in the history of life. Explores how life has made its way on our planet with forms of agency as diverse as those shown by bacteria, plants or animals. bit.ly/4ahuBmV #evolution @julipereto.bsky.social

📢 Call for a postdoctoral position in virology

📍 Institute of Virology, Medical University of Innsbruck, Austria
🕘 5 years | Full-time
📅 Starting 1 April 2026

🔗 Apply: virologie.i-med.ac.at/postdoctoral...

#CapacityStrengthening @geroldlab.bsky.social

New positions in CSIC published, some at @i2sysbio.es . Come join our institute. www.ciencia.gob.es/es/Ministeri...

A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus Omicron sublineages of SARS-CoV-2 have accelerated the spread of the virus and facilitated immune escape. In this work, we demonstrate that compound 2, a potent HIV and enterovirus A71 (EV-A71) entry inhibitor previously discovered in our research group, also displays potent in vitro activity against different SARS-CoV-2 Omicron variants while showing no activity against the ancestral SARS-CoV-2 Wuhan strain. Moreover, its sodium salt (2-Na salt) exhibited in vivo antiviral activity in a murine model of Omicron BA.1. infection. Indeed, biophysical and cryo-EM studies revealed binding of 2-Na salt to the Omicron BA.1 spike (S) protein stabilizing a “closed” form in which ∼75% of the S particles have all RBDs down, unlike the usual “open” form with one RBD up. Such “closed” form decreases S avidity for the cellular receptor ACE2, thus inhibiting viral entry. Computer-assisted modeling studies strongly suggest that 2 can interact with the intersubunit cavity of the S trimer of the Omicron BA.1 subvariant, making use of the multivalency principle. In this context, compound 2 can be considered a pharmacological tool for studying and validating new antiviral strategies against Omicron variants. We also identified 2 as a potent inhibitor of RSV and the Ebola virus. The effectiveness of 2 against a diverse set of viruses of different families supports its use as a promising lead for the development of entry inhibitors against current and future viral infections, representing a meaningful advance in the field.

Another collaborative effort to uncover new broad-spectrum antivirals! This one works for SARS-CoV-2, respiratory syncytial virus, and Ebolavirus (as well as HIV and EVA71 from another work). pubs.acs.org/doi/10.1021/...

You know something exciting is happening when three lab members are working together to get it done!

ComFuturo Fourth Edition: ComFuturo iAGE Call - FGCSIC The Fundación General CSIC (FGCSIC) launches the fourth edition of its ComFuturo programme: ComFuturo iAGE, a postdoctoral initiative co-financed by the Marie Skłodowska-Curie Actions COFUND scheme of...

🚨JOB ALERT

Dr. Buceta at @i2sysbio.es welcome applications for 36-month postdocs on:

👉 Mechanical markers of tissue dysfunction due to ageing – digital twins & machine learning

Details here: fgcsic.es/convocatoria...
📩 Contact javier.buceta@csic.es to shape your proposal!

@epimechfc.bsky.social

Thanks for sharing, Marco. A clever way to get around neutralizing antibody issues for oncolytic virus delivery!

New study! We compared the first two full-proteome Enterovirus DMS datasets and found both shared and unique selection pressures—plus conserved druggable pockets. Great collaboration with @ptdolan.bsky.social ’s team!
dx.doi.org/10.21203/rs....

@bealro.bsky.social @i2sysbio.es

Quedan 2 semanas para postular a un doctorado en nuestro laboratorio (interacciones arbovirus-hospedador).

🎓 Título universitario (fuera de la UE, >2020) + máster relevante requeridos.

🔍 Detalles: i2sysbio.es/position/7/.

#PhDposition #Virología #Arbovirus 🦟🧬🌍

📢 Exciting news! We will soon open two PhD positions at @i2sysbio.bsky.social @csic.es, in research projects in collaboration with the @bsc-cns.bsky.social. Both are related to tools to simulate biological tissues. Here’s the description of the open positions. #PhDpositions #PhDOpportunities
👇

A recent effort from the enterovirologists in the @rongellerlab.bsky.social. Interested in making or utilizing fluorescent reporter enteroviruses? Take a look. A Fluorescent Reporter Virus Toolkit for Interrogating Enterovirus Biology and Host Interactions www.preprints.org/manuscript/2...

4-year PhD fellowship in Virology available in our group @i2sysbio.bsky.social. Eligibility requires having a relevant university degree from outside of the EU obtained after 1/1/2020 and having (or soon to have) a relevant Master degree (preferably from Spain). See i2sysbio.es/position/7/

Un excelente resumen de nuestros resultados recientes sobre el descubrimiento de nuevos antivirales para SARS-CoV-2 y el virus sincitial respiratorio.

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity Communications Biology - Identification of safe and effective broad-spectrum antivirals based on modified chitosan sulfate derivatives.

Our recent collaborative work showing the promising broad-spectrum antiviral activity of chitosan sulfate derivatives against SARS-CoV-2, RSV, and Sindbis virus is finally online. Check it out! Detailed mechanisms and in vivo characterization included! rdcu.be/eb9IQ

The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...

Latest #virology research from the lab! 👇

Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.

www.biorxiv.org/content/10.1...

Yesterday we had the first #ValenciaVirologyMeeting. Great to see we have a solid virology community right here! Thanks Rafa Sanjuan and @SantiagoFElena for helping to chair our discussion on de novo virus design and synthetic viruses and Jesus Rodriguez Diaz for co-organizing.

Making recombinant VSV? Our codon-optimized helper plasmids are now available at @Addgene: www.addgene.org/Ron_Geller/. Method details here: www.nature.com/articles/s41...

An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins - Scientific Reports Scientific Reports - An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins

Just shipped our optimized helper plasmids for producing recombinant VSV to Addgene/@addgene.bsky.social from our recent paper (www.nature.com/articles/s41...). Keep an eye out for them if you make recombinant VSV.

A farewell lunch to Marianoel Pereira from Pasteur Institute of Montevideo in Uruguay who spent a couple of months in our lab learning high-fidelity Illumina sequencing of viruses.