A big thank you to all authors, especially Marius Halliez and Laure Strochlic for their incredible contributions to this project!
01.07.2025 17:21
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Our collaborators showed that passive transfer of anti-MuSK CRD antibodies in mice induced hallmark features of #myastheniagravis (MG), providing the 1st evidence of the MuSK CRD domain’s involvement in MG pathogenesis and advancing our understanding of its underlying pathophysiological mechanisms.
01.07.2025 17:21
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As part of our team in @neuromagendie.bsky.social – INSERM U1215 and the Bioprot Platform in @neurobordeaux.bsky.social , we designed and carried out the purification of the MuSK CRD peptide, a key step that enabled the successful production of rabbit anti-MuSK CRD antibodies.
01.07.2025 17:21
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JCI -
MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis
I'm thrilled to share our contribution in a collaborative work with Laure Strochlic ‘s team, that is now published in the Journal of Clinical Investigation!
www.jci.org/articles/vie...
01.07.2025 17:21
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Beautiful periodicity!
26.05.2025 17:53
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BBs?
05.04.2025 09:38
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Thrilled to host the #Syncell Inc #Microscoop event on March 21st in #Bordeaux!
Anybody interested in the prospects of #spatialproteomics is more than welcome!
📍 **Location:** Amphi Broca Nouvelle Aquitaine, Bordeaux
📅 **When :** March 21st, 2:00pm-3:30pm
03.03.2025 07:05
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PhosX: data-driven kinase activity inference from phosphoproteomics experiments
AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru
Kinases play a role in many diseases, making them prime targets for therapeutic intervention.
Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.
Read the full article: academic.oup.com/bioinformati...
@alussana.bsky.social @epetsalaki.bsky.social
27.01.2025 11:56
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already a must read. The latest about the #axoninitialsegment !
16.02.2025 07:46
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The Martin lab has an open postdoc position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community!
If interested, do not hesitate to contact us: mocel.unige.ch/research-gro...
Please RT!
23.10.2024 16:24
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Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues.
www.cell.com/cell/fulltex...
08.01.2025 13:06
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Cartoon of the mechanism from the last figure of Thyagarajan et al.
A neuronal Rube Goldberg machine 🤯
Wnt from surrounding cells is internalized via clathrin-coated pits at dendritic branch points before triggering microtubule nucleation at the surface of endosomes. Great work from Melissa Rolls' lab in @plosbiology.org: journals.plos.org/plosbiology/...
08.01.2025 21:54
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nice dice set!
23.12.2024 06:40
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at least, the "massues" are not on fire!
18.12.2024 04:50
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I wish I had this a few years back!
10.12.2024 21:26
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