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Simon Roux

@simrouxvirus

Virus-obsessed bioinformatician, DOE JGI Scientist, Enjoy exploring the viral world with #metagenomics and other cool #omics toys. He/him. Opinions my own.

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Latest posts by Simon Roux @simrouxvirus

Un poste MCF en génomique évolutive / écologie moléculaire à ECOBIOP - Université de Pau #PopGen 👇
urlr.me/rVQmN6

05.03.2026 14:21 👍 1 🔁 3 💬 0 📌 0
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Viruses in marine sediments: a review of their effect on biogeochemistry and microbial interactions | Applied and Environmental Microbiology In the ocean, viruses are known to mediate the carbon cycle, keeping dissolved organic carbon (DOC) in the microbial loop and preventing its movement into secondary consumers (1). However, few direct ...

New paper out! We sat down and compiled all viral work in marine sediments. The water column has been getting a second look for viral interactions, its time for sediment to have the same!
journals.asm.org/doi/10.1128/...

05.03.2026 14:05 👍 48 🔁 18 💬 3 📌 2
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🧫 Just out in Bioinformatics Advances: "AssiST: Convolutional neural network for analysis of antibiotic susceptibility testing" 

Read the full paper here:  https://doi.org/10.1093/bioadv/vbag063

Authors include: @carmenli.bsky.social, @amitchell.bsky.social

04.03.2026 14:39 👍 5 🔁 3 💬 2 📌 1

CRISPR targeting seems to suggest it's definitely not as "rare" as we may have thought, especially in situations like micro-aggregates, etc

03.03.2026 22:02 👍 3 🔁 0 💬 1 📌 0

➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔

🧵👇

02.03.2026 08:36 👍 75 🔁 45 💬 1 📌 3
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This scalability unlocks extensive cross-proteome discovery. By querying viral proteomes against host genomes, FlashPPI identifies host-virus interactions involving previously uncharacterized proteins. 6/

03.03.2026 15:07 👍 2 🔁 2 💬 1 📌 0
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Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.

We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵

03.03.2026 15:07 👍 67 🔁 27 💬 2 📌 7
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With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

03.03.2026 08:58 👍 221 🔁 95 💬 5 📌 13
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The Voyageurs Wolf Project of Northern Minnesota tags & documents grey wolf ecology & behavior: www.voyageurswolfproject.org

The video you see here is confirmatory proof:
Wolves. Love. Blueberries.

As much as 83% of a wolf's calories in summer months comes from eating berries.

02.03.2026 13:58 👍 1642 🔁 604 💬 19 📌 79

🔔Seminar Opportunity🔔

We're looking for (self)recommendations for a Postdoc who is working in the area of AMR (any area, any discipline) to give an online seminar in May.

Reply, DM or email me, there will more opportunities in the future as well so will be good to have a list.

#MicroSky #AMR

02.03.2026 14:59 👍 9 🔁 16 💬 0 📌 0

Posting again!

24.02.2026 15:49 👍 4 🔁 10 💬 0 📌 0

Given that clonal biofilms of single bacterial species rapidly diversify into niche specialists, how do biofilms of multiple species evolve?
A 🧵 featuring new collaborative pubs:
1. www.biorxiv.org/content/10.6...
2. www.nature.com/articles/s41...

01.03.2026 18:53 👍 47 🔁 19 💬 1 📌 0

This is brilliant

01.03.2026 19:38 👍 25 🔁 5 💬 1 📌 0
PearTree — Phylogenetic Tree Viewer

So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the “Example...” button for immediate candy and then click every button you can find).

28.02.2026 19:01 👍 160 🔁 99 💬 5 📌 4
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These wee birds are just zen

28.02.2026 01:45 👍 7 🔁 1 💬 0 📌 0

Post a pic you took, no context, to bring some zen to the feed.

28.02.2026 01:14 👍 16 🔁 2 💬 0 📌 1

Post a pic you took, no context, to bring some zen to the feed.

28.02.2026 01:17 👍 3 🔁 1 💬 0 📌 0
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I have the same cat

28.02.2026 00:41 👍 2 🔁 1 💬 0 📌 0
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28.02.2026 00:47 👍 3 🔁 1 💬 0 📌 0
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28.02.2026 01:06 👍 3 🔁 1 💬 0 📌 0

Post a pic you took, no context, to bring some zen to the feed.

28.02.2026 00:19 👍 27 🔁 5 💬 5 📌 3

But this is so new that we 100% need more perspective and "cautionary tales" from people who have looked at these data in detail and thought deeply about these questions !!

27.02.2026 18:35 👍 7 🔁 0 💬 1 📌 0

"not perfect" for prophages either, "very not perfect" for lytic viruses 😁
We touch on this a bit in our "host prediction" review www.sciencedirect.com/science/arti...
and the Sullivan lab has done benchmarking that highlights the potential noise in these data
journals.plos.org/plosbiology/...

27.02.2026 18:35 👍 14 🔁 2 💬 1 📌 0

Also, g’damnit I need to write up the “Hi-C is not perfect when identifying plasmids and host cells” paper

27.02.2026 18:23 👍 10 🔁 1 💬 1 📌 0
Formalizing our commitment to code sharing In support of open science, PLOS Biology routinely asks authors to openly share their research code before publication. We are now formalizing this practice with a mandatory code sharing policy and cl...

New @plosbiology.org code sharing policy. In this Editorial, @npariente.bsky.social and Lauren Cadwallader explain the policy and offer guidance on compliance, noting that code sharing remains less well understood than equivalent requirements for data and ethics.

journals.plos.org/plosbiology/...

27.02.2026 15:07 👍 7 🔁 5 💬 0 📌 0
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We’re recruiting new Research Group Leaders!
We offer:
🔬 Core funding
💻 Access to world-leading infrastructure
👩🏽‍🔬A network of world-leading scientists
…and much more.
Apply by 11 April: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
#ResearchCareers #Bioinformatics @timcoorens.bsky.social @embl.org

25.02.2026 10:24 👍 20 🔁 20 💬 0 📌 1
On this day on February 26, 1948, the Max Planck Society was formally founded in Göttingen as the successor organization to the Kaiser Wilhelm Society,  in the cafeteria of the KWS's aerodynamic testing facility in Göttingen.

On this day on February 26, 1948, the Max Planck Society was formally founded in Göttingen as the successor organization to the Kaiser Wilhelm Society, in the cafeteria of the KWS's aerodynamic testing facility in Göttingen.

Happy birthday to....well, to us, actually! 😉🎂🥳 On this day on February 26, 1948, the Max Planck Society was formally founded in Göttingen as the successor organization to the Kaiser Wilhelm Society, in the cafeteria of the KWS's aerodynamic testing facility in Göttingen.

26.02.2026 15:41 👍 50 🔁 9 💬 4 📌 0
Overview — AllTheBacteria documentation

Courtesy of @martibartfast.bsky.social , we have a new release of AllTheBacteria which adds another 322,920 assemblies, covering all ENA (illumina, isolate) prokaryotes to May 2025.
allthebacteria.readthedocs.io/en/latest/ov...

26.02.2026 15:48 👍 60 🔁 28 💬 0 📌 3
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Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews on FindAPhD.com PhD Project - Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews, listed on FindAPhD.com

📢 Funded PhD in molecular microbiology & phage biology

How do bacterial stress responses control prophage activation and horizontal gene transfer?

Join us at St Andrews to dissect Clp protease–mediated regulation in Staphylococcus aureus.

Apply:
www.findaphd.com/phds/project...

25.02.2026 14:39 👍 14 🔁 18 💬 1 📌 2