Mike Cohen

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases t...

I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...

Congrats Karolin for this well deserved award!

The PARP Family & ADP-ribosylation Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Registration deadline extended to January 31, 2026. Join us @nucleosomepolice.bsky.social @leunglab.bsky.social at CSHL for the PARP Meeting—connect with leaders and rising stars from academia and industry. Please kindly repost!
.https://meetings.cshl.edu/meetings.aspx?meet=parp

Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.

The PARP Family & ADP-ribosylation Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...

very cool, team Balyn-congrats!

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...

Chemoproteomic elucidation of β-lactam drug targets in Mycobacterium abscessus The pathogen Mycobacterium abscessus ( Mab ) can cause severe and difficult to treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are...

New work from my team, identifying drug targets in M. abscessus. Pre-print posted here:
www.biorxiv.org/content/10.6...

Looking forward to the biannual #CBP2025 conference @ohsunews.bsky.social starting this week! incredible line up of speakers, including keynotes @mbogyo.bsky.social, @christhechang.bsky.social, and Nancy Carrasco.

www.ohsu.edu/school-of-me...

Congrats!

Excellent study by first author @andriigorelik.bsky.social in @ahellab.bsky.social showing how DTX2 tunes AHR transcription and stability, offering deeper insight into ADP-ribosylation–ubiquitylation crosstalk.

Happy to have made a small contribution during my mini-sabbatical in @ladurner.bsky.social lab!

They demonstrate that a common PARP1 variant (V762) shifts talazoparib from a non-retentive (Type II) to an allosteric, pro-retention (Type I) mode, thereby boosting chromatin trapping and cancer cell killing. The finding makes a strong case for genotype-guided dosing in HRD cancer therapy.

Talazoparib stands out for its strong potency and DNA "trapping" in certain cancers, but why this happens wasn’t clear. A new preprint from first author Jin Cai in the @ladurner.bsky.social lab, together with Ben Black’s team, address this in a new preprint: www.biorxiv.org/content/10.1...

Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....

My quote of the day

A Video Quote

Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.

(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows

'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

Congrats Jeremy! Well-deserved!

Exciting times in the fields of ADP-ribosylation and ubiquitylation!

This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41...

And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...

reveal RNF114 as a reader and writer of MARUbylation.

Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.

Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.

Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!

Very cool finding, Matt. Congrats!

💯 👇!

Great seeing both of you!

Today they have crossed a deep red line.

We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.