Danilo Negro

Had a brilliant time speaking at @pintofscience.uk with my talk “Gold, Guns and Brain Cells” — exploring neurodegeneration and resilience in Alzheimer’s disease.
Huge thanks to everyone who came, asked thoughtful questions, and made it such a fun night! 🧠🍻 #pint25

Fantastic coverage of our recent work using living human brain slices to study Alzheimer’s disease from @itvnews.bsky.social

www.itv.com/news/2025-04...

Living human brain tissue used to mimic Alzheimer’s in breakthrough study Exclusive: British team exposed live cells to toxic proteins to gather rare insight into how dementia develops Scientists have used living human brain tissue to mimic the early stages of Alzheimer’s disease, the most common form of dementia, in a breakthrough that will accelerate the hunt for a cure. In a world first, a British team successfully exposed healthy brain tissue from living NHS patients to a toxic form of a protein linked to Alzheimer’s – taken from patients who died from the disease – to show how it damages connections between brain cells in real time. Continue reading...

Living human brain tissue used to mimic Alzheimer’s in breakthrough study

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

The Resilient Mind: Fighting Against Dementia Join us for an insightful event exploring the fascinating world of the brain. The first talk dives into the science of neurodegeneration, where brain cells…

Curious about how the brain might adapt to neurodegeneration? Come hear me talk about gold, guns and brain cells at @pintofscience.uk in Edinburgh! 🧠🍻 #pint25

Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.