Institut Cochin (@institutcochin)

Congrats to Alberto Iannuzzo for the 2025 thesis prize from the Research and Study Group on Mediators of Inflammation (GREMI) for his thesis carried out at @institutcochin.bsky.social under the supervision of Jérôme Delon and Isabelle Meyts
institutcochin.fr/en/news/albe...

05.03.2026 13:44 👍 0 🔁 0 💬 0 📌 0

#seminar on March 12 at noon by Guillaume Tosato (FunGeST, @crcordeliers.bsky.social) #Immunotherapy response in pleural #mesothelioma modulated by histomolecular features and myeloid composition: From clinical trials to in vitro modeling
institutcochin.fr/en/agenda/im...
@parispostdocs.bsky.social

05.03.2026 13:36 👍 1 🔁 0 💬 0 📌 0

Microbial viability drives immunometabolic responses of macrophages Johan Garaude is an outstanding cell biologist and immunologist, who is currently leading the Mitochondrial Biology and Innate Immunity team at ImmunoConcEpT. His team is interested in the cellular metabolism of myeloid cells and how it contributes to innate immunity against microbial pathogens. The laboratory particularly deciphers the mechanism linked to mitochondrial adaptations and nutrient usage in macrophages. Recently, Johan Garaude recently contributed to show how macrophages recycle ingested bacteria to feed their own metabolism. Using original metabolomic approaches, his team elegantly demonstrated that macrophage use phagocytosed bacteria as a source of nutrients that feed various metabolic pathways including protein synthesis, anti-oxidant responses or central metabolism. Furthermore, his group has shown that microbial viability dictates the fate of ingested cargo by articulating specific metabolic pathways and by re-organizing the architecture of the mitochondrial respiratory chain in phagocytic cells. Johan Garaude is invited by Fatah Ouaaz.

#seminar on March 5 at noon: Microbial viability drives immunometabolic responses of #macrophages, by
Johan Garaude (Mitochondrial Biology and Innate Immunity Team, ImmunoConcEpT, Bordeaux, FR)
institutcochin.fr/en/agenda/mi...
@cnrsbiologie.bsky.social @upcite.bsky.social @inserm.fr

26.02.2026 11:35 👍 0 🔁 0 💬 0 📌 0

1er #Formation sur les bases de l'immuno #Fluorescence pour la microscopie photonique 🔬 à @institutcochin.bsky.social

institutcochin.fr/formations/f...

@upcite.bsky.social
@inserm.fr
@cnrsbiologie.bsky.social

25.02.2026 16:49 👍 1 🔁 1 💬 0 📌 0

Macrophage makeover extreme viral edition: mechanisms of immune subversion and therapeutic perspectives Macrophages are versatile innate immune cells that play a crucial role in immune responses and tissue repair. However, their plasticity and central role in immunity also make them prime targets for vi...

www.microbiologyresearch.org/content/jour...

24.02.2026 14:06 👍 0 🔁 0 💬 0 📌 0

Macrophage & virus copyrights: Z. Fremont-Debaene & S. Faure-Dupuy, CC-BY 4.0

New publication! #Macrophages are central players in innate #immunity. Viruses exploit their plasticity to evade host defenses or trigger excessive #inflammation. Journal of General Virology by Zoé Fremont-Debaene & Suzanne Faure-Dupuy.
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

24.02.2026 14:04 👍 2 🔁 0 💬 1 📌 0

Catherine Postic

👏 Catherine Postic, deputy director @institutcochin.bsky.social, has been elected as a foreign associate member of the Royal Academy of Medicine of Belgium. This prestigious distinction recognizes the excellence of her research on metabolism and testifies to the international reach of her expertise.

04.02.2026 10:22 👍 3 🔁 1 💬 0 📌 0

Reminder: #seminar on February 5 at noon by Serena Janho dit Hreich (Immunity and Cancer, @institutcurie.bsky.social): Interplay of Cancer-Associated Fibroblasts and invasive clusters of tumor cells drives progression in early stages of bladder cancer
institutcochin.fr/en/agenda/in...

04.02.2026 10:13 👍 0 🔁 0 💬 0 📌 0

📣 The February newsletter of the #ParisPostdocsSeminars is out! Don't miss the exciting talks happening next week at @ibensens.bsky.social, #UFR-Sciences, and @institutcochin.bsky.social

And save the dates 📆 for the ones taking place in the second half of the month!

#seminar #networking #Paris

30.01.2026 13:02 👍 4 🔁 6 💬 1 📌 0

Post-Acute Infectious Syndromes: A useful and constructive meeting between patients, associations, physicians and researchers @institutcochin.bsky.social.
institutcochin.fr/en/actualite...
#LongCOVID #longLyme #myalgic encephalomyelitis
@cnrsbiologie.bsky.social @upcite.bsky.social @inserm.fr

28.01.2026 13:47 👍 8 🔁 4 💬 2 📌 0

Interplay of Cancer-Associated Fibroblasts and invasive clusters of tumor cells drives progression in early stages of bladder cancer Bladder cancer progression from non-muscle invasive (NMIBC), particularly the T1 stage, to muscle invasive disease (MIBC) represents a critical clinical transition requiring aggressive therapy due to high metastatic recurrence risk. Risk of progression of T1 tumors is mainly based on the presence of invasive tumor cells breaching the urothelial layer and invading the lamina propria. However, cellular and molecular events occurring in the tumor microenvironment (TME) that drive this progression remain poorly defined. To address this knowledge gap, we investigated the changes within the TME associated with the progression of bladder cancer. Single-cell RNA sequencing (scRNAseq) analysis of untreated NMIBC and MIBC human samples, alongside multiplexed imaging, revealed extensive cancer-associated fibroblast (CAF) remodeling as a key feature associated with disease progression. We show that activated CAFs are present in small focal patches in T1 tumors that surround a subset of invasive tumor cells. Both cell types were more strongly associated with progression into MIBC than either population alone, supporting the interaction of these two cell types to promote tumor progression. I will address the implicated cross-talk using multiplex imaging, spatial transcriptomics, scRNAseq and in vitro assays. Overall, we highlight the importance of the stromal compartment and the cross-talk between specific populations of CAFs and tumor cells that may serve as a prognostic biomarker and therapeutic target in NMIBC. Paris post-doc seminar series.

#seminar on February 5 at noon by Serena Janho dit Hreich (Stroma & Immunity Team-Immunity and Cancer, @institutcurie.bsky.social): Interplay of Cancer-Associated Fibroblasts and invasive clusters of tumor cells drives progression in early stages of bladder cancer
institutcochin.fr/en/agenda/in...

28.01.2026 13:12 👍 0 🔁 0 💬 0 📌 0

Samedi 24 janvier 2026 - Accueil des nouveaux membres académiciens belges et étrangers

👏 Catherine Postic est élue en tant que membre associée étrangère à l'Académie royale de Médecine de Belgique. Cette distinction prestigieuse couronne l’excellence de ses travaux de recherche sur le métabolisme et témoigne du rayonnement international de son expertise.
mailchi.mp/ea460949a873...

21.01.2026 12:58 👍 1 🔁 0 💬 0 📌 0

Genetic insights into drug-resistant Plasmodium falciparum malaria David Fidock is faculty at Columbia University in New York and the new scientific advisor to the Institut Pasteur president. Plasmodium falciparum is tremendously skilled at overcoming therapeutics and host immunity. P. falciparum causes severe malaria in over half a billion individuals and kills over a million African children yearly. It also prevents sterilizing immunity even in individuals who have been infected thousands of times. Disease can result from severe anemia, hyperparasitemia, or other complications resulting from sequestration of parasitized red blood cells. Chemotherapeutic clearance of blood stage parasites is the key to malaria treatment and control, however it is systematically thwarted by the acquisition of resistance. David Fidock is invited by Molly Ingersoll and Catherine Lavazec.

#Seminar on January 8, 2026 at noon by David A. Fidock ( @pasteur.fr): Genetic insights into drug-resistant #Plasmodium falciparum malaria
institutcochin.fr/en/agenda/ge...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social @cnrs-idf-villejuif.bsky.social

07.01.2026 10:26 👍 0 🔁 0 💬 0 📌 0

Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia - Communications Biology An integrative proteo-transcriptomic analysis reveals conserved post-transcriptional regulation mechanisms in acute myeloid leukemia and introduces POSTCODE, a tool to detect regulatory alterations in...

New paper by Khadra E. et al. & Ismael Boussaid "Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia" in Nat. Commun. Biology!
🔎 doi.org/10.1038/s420...
#AML #RNA #Proteomics #Bioinformatics #CancerResearch
@cnrs.fr @inserm.fr @upcite.bsky.social

17.12.2025 12:24 👍 3 🔁 2 💬 0 📌 0

Do not miss this seminar tomorrow: institutcochin.fr/en/agenda/de...

10.12.2025 11:33 👍 1 🔁 0 💬 0 📌 0

@institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social

09.12.2025 08:21 👍 0 🔁 0 💬 0 📌 0

Portrait de chercheur : Catherine Postic Les travaux de Catherine Postic sont consacrés aux mécanismes moléculaires et biochimiques qui régulent le métabolisme énergétique en modulant le dialogue inter-organes, en particulier entre le foie e...

Toutes nos félicitations à Catherine Postic, directrice de recherche au CNRS à l’Institut Cochin (Inserm : Paris & Île-de-France U1016/CNRS UMR 8104/Université Paris Cité), lauréate 2025 du Prix Odile et Gilles Taldu de la Fondation pour la Recherche Médicale!
www.frm.org/fr/actualite...

09.12.2025 08:17 👍 6 🔁 0 💬 1 📌 0

Happy to share that I will be presenting at #CellBio2025 this afternoon during the #CSCB session in room 108 our work on #phagocytosis by #macrophages mannose receptor done @institutcochin.bsky.social by @chiarapompili.bsky.social with @jfattaccioli.bsky.social and @jean-Maurice Mallet

08.12.2025 15:02 👍 9 🔁 4 💬 0 📌 0

#seminar by Stéphane Nedelec (Team "Human Neurodevelopment & disorders", @ijmonod.bsky.social, Paris) on December 11 at noon. Deconstructing human nervous system development with #stem-cell derived models
institutcochin.fr/en/agenda/de... @inserm.fr @cnrs-paris-saclay.bsky.social @upcite.bsky.social

04.12.2025 16:26 👍 4 🔁 1 💬 1 📌 1

It is tomorrow: institutcochin.fr/en/agenda/pr...

03.12.2025 15:49 👍 0 🔁 0 💬 0 📌 0

More than 40 million people live with HIV in the world, with 1.3 million of new infections every year.
At Institut Cochin, four research teams are dedicated to understanding HIV mechanisms through several research axes.
@inserm.fr,
@cnrs-paris-saclay.bsky.social,
@upcite.bsky.social

01.12.2025 07:47 👍 3 🔁 1 💬 0 📌 0

L'Institut Cochin annonce la soutenance de thèse de Patricia Vaduva.

Direction :
Dr Annabel Berthon et Pr Jérôme BERTHERAT, (institutcochin.fr/equipes/geno...)

📅 27/11/2025
📍 Institut Cochin

#these #recherchefondamentale
@inserm.fr erm.fr, @cnrsbiologie.bsky.social ial, @upcite.bsky.social

27.11.2025 19:07 👍 5 🔁 1 💬 1 📌 0

#seminar on December 4 at 12:00 by Srikanth RAVISHANKAR (Genetics of Biofilm Unit, Dept of Microbiology, @pasteur.fr): A promising antivirulence and #biofilm -targeting strategy against #Escherichia coli
institutcochin.fr/en/agenda/pr...
@cnrs-idf-villejuif.bsky.social @inserm.fr @upcite.bsky.social

27.11.2025 09:33 👍 5 🔁 2 💬 1 📌 1

Seminar tomorrow ⬇️
institutcochin.fr/en/agenda/id...

27.11.2025 09:09 👍 1 🔁 1 💬 0 📌 0

@inserm.fr
@cnrsbiologie.bsky.social
@cnrs-idf-villejuif.bsky.social
@upcite.bsky.social

26.11.2025 17:46 👍 0 🔁 0 💬 0 📌 0

Electron microscopy image of tubular membrane structures (in orange) of an infected endothelial cell, produced by meningococcus. Credit: Mathieu Coureuil.

Work by A. Laurent & K. Sollier, in collaboration between the teams of Stefano Marullo (U1016), Mathieu Coureuil (U1151), and Nicolas Borghi (UMR7592), published in Nat. Commun.! 🔎Doi: doi.org/10.1038/s414...
#Research #LifeSciences #BiomedicalResearch #InfectiousDiseases #HostPathogenInteractions

26.11.2025 17:40 👍 4 🔁 0 💬 1 📌 0

Do not miss this seminar tomorrow: institutcochin.fr/en/agenda/mo...

26.11.2025 08:15 👍 2 🔁 0 💬 0 📌 0

L'Institut Cochin annonce la soutenance de thèse de Tony Rached.

Direction :
Equipe de Michaela Fontenay et Yannick SIMONI, Hématopoïèse normale et pathologique (lnkd.in/eiQVH5Bu)

📅 27/11/2025
🕓 14h00
📍 Institut Cochin

#these #science
@inserm.fr, @cnrsbiologie.bsky.social, @upcite.bsky.social

25.11.2025 18:57 👍 1 🔁 0 💬 0 📌 0

Chez les femmes, l’un des deux chromosomes X est systématiquement inactivé !
Pour en savoir plus, cette vidéo www.youtube.com/watch?v=mFxy... réalisée par Anaïs Poncet et produite par Universcience, avec l’intervention d’Edith Heard et de Julie Chaumeil (institutcochin.fr/equipes/epig...).

25.11.2025 18:55 👍 1 🔁 2 💬 0 📌 0

Seminar today by Julie Lesieur at noon in the Rosalind Franklin Room "Breaking news: There are other techniques than confocal !"
@institutcochin.bsky.social
@upcite.bsky.social
@inserm.fr
@cnrs.fr

24.11.2025 08:49 👍 3 🔁 1 💬 0 📌 0

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