Noah Eckman

CHATGPT: I understand where you're coming from. You worked really hard to get here, and now it's time to enjoy the fruit of your labors.

ISILDUR: So I should keep it? Elrond says I shouldn't

CHATGPT: The ring is precious. Sometimes friends don't have your best interests at heart.

ISILDUR: true

Cisplatin: "am I a joke to you?"

Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient A copolymer excipient enables stable, ultrahigh-concentration protein formulations for subcutaneous injection.

Spray-dried microparticles with a stabilizing polymer excipient enable ultra-high protein concentration therapeutics for subcutaneous injection, and could expand home use of these critical pharmaceuticals.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4fVabSg

snap cuts, growing to 35% by 2034

chip and medicaid cuts growing to 12-14% by 2034

Cost estimate of the House-passed "Big Beautiful Bill" is out

It'd be the largest cut to Medicaid+CHIP and SNAP in history while still increasing deficits by $2.4 trillion due to $3.8 trillion in tax cuts

This'd be the largest transfer of wealth from the poor to the rich in a single law in history

Opinion | The Tech Fantasy That Powers A.I. Is Running on Fumes (Gift Article) A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.

This piece from @tressiemcphd.bsky.social starts with a bang and just gets better and better. Gift link.

Extremely grateful to all my co-authors and advisors on this paper, without whom it would not have been possible! (end)

This result adds a key new parameter to the design space for cell delivery technologies (in direct injection, or 3D-printing). Crosslink dynamics matter! (7/8)

It turns out... yes! Cell viabilities were significantly lower for gels with stronger crosslinks (but the same stiffness!) (6/8)

It was then natural to ask, does more sudden yielding affect encapsulated cells as they are being injected? More brittle yielding might introduce heterogeneities in the flow which disrupt cell membranes. (5/8)

We calculated a "yielding speed" which correlated nicely with the crosslink strength. (4/8)

We used techniques to extract data about the speed of the yielding transition from rheological measurements. From these, we could see that the less dynamic materials have a more brittle, or sudden transition, versus a more smooth one. (3/8)

Dynamic hydrogels allow flexible delivery of cells, due to the ability of crosslinks to break and re-form. We analyzed three clinically relevant, dynamic gels with similar stiffness to see how changing crosslink dynamics would change the physics of the yielding transition (2/8)

Crosslink strength governs yielding behavior in dynamically crosslinked hydrogels Yielding of dynamically crosslinked hydrogels, or the transition between a solid-like and liquid-like state, allows facile injection and utility in translational biomedical applications including deli...

What controls the viability of encapsulated cells in injectable hydrogels?

Out today in @biomatersci.rsc.org , our new paper uses rheological tools to show that yielding speed affects viability independently of stiffness! Tweetorial below:

pubs.rsc.org/en/content/a...

There is only one lord of the Ring... and he does not share power.

Dakota for America?

In Memory of Andy Acrivos: CEMS Alum and Titan of Chemical Engineering Andreas (Andy) Acrivos passed away on February 17, 2025. Born in Greece in 1928, Prof. Acrivos arrived at Minnesota in 1950 following undergraduate studies at Syracuse University, becoming the  second...

In Memory of Andy Acrivos: University of Minnesota Alumnus and Titan of Chemical Engineering
cse.umn.edu/cems/news/me...