Yes! Various theory papers about this. The nanostar system is well suited to explore programmed crosstalk…. Funding willing, we might explore this
19.02.2026 16:11
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Yes! Various theory papers about this. The nanostar system is well suited to explore programmed crosstalk…. Funding willing, we might explore this
Yes we could, but not in this study where we engineered things to have as little crosstalk as possible. We checked and the Tm of a given phase is about the same regardless of the presence of the other eight phases.
We argue in the paper that this ‘zero crosstalk’ limit is easier to achieve with DNA
Work led by spectacular student Aria Chaderjian, with key insights from @samwilken.bsky.social
Paper available here:
www.pnas.org/doi/10.1073/...
(3/3)
…we further show that appropriate thermal processing lead to metastable jammed-droplet layers, which are kinetically stabilized by cages formed from the diverse immiscible phases… so new types of structure and dynamics are possible with this system (2/3)
New from us in @pnas.org :
We considered the limits of condensate diversity, and engineered DNA droplets to form 9 distinct, homotypic, coexisting phases. Very hard to do this except with nucleic acids. Probably you can make more than 9. (1/3)
Sorry! Please feel free to return to your regularly scheduled doom scrolling.
… With enzymatic degradation, a curious behavior in which droplets disappear while their avg radius stays constant (red images).
Lovely work by post doc fellow Michio Tateno. Check out the paper at the link.
doi.org/10.1103/x2pf...
New paper from us in PRL:
Precision measurements of DNA condensate droplets as modulated by diffusive (Ostwald) or enzymatic processes. We verify LSW models of Ostwald ripening at the level of single droplets (blue images), and observe dynamic scaling of the size distribution….
I am not sure it is a major conflict. The poster is correct that the scaffold concept has been taken too far in certain cases. But he is not questioning the entire condensate/LLPS field; to the contrary he praises certain approaches
Check out our paper on transcriptional control of an artificial condensate, including engineering a feedback loop that includes phase separation. Led by the amazing @samwilken.bsky.social
Done! Run fast!
PRX Life seems like a good choice, though maybe you are thinking to aim higher? It is a great result
“As a public university, we are stewards of taxpayer resources, and a payment of this scale would completely devastate our country’s greatest public university system as well as inflict great harm on our students and all Californians.” —UC President James B. Milliken
Best time to come is the winter, for the obvious reason (maximal weather difference between Canada and here) but also because it is the clearest time, and you get great views of the islands from that particular room
Maybe the new NSF will fund this
Seems like the kind of thing the administration will like
How many of you are there
Hey this looks fun
Congrats!
Indeed
No
I believe research gov went down and came back up without any issues or changes
This whole thing was strange from the start; we have all sorts of email trails and office of research paperwork on awards, right?
This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
APSMarch attendees: eat to bed early so you can get to the 8am session on Friday: Bioinspired phase separation, wi the Lorenzo Di Michele and many other great speakers.
8am sharp in the Hilton 4th floor Palos Verdes room
summit.aps.org/events/MAR-W64
Note excellent invited speakers on both days starting at 8am sharp!
For those condensate and active fluid fans attending the APS meeting next week, please wake up early and come to our 8am sessions on Thursday and Friday, co organized by myself, Ahmad Omar, Lauren Zarzar, and Sam Wilken
Details here:
summit.aps.org/events/MAR-Q64
summit.aps.org/events/MAR-W64
Yeah I saw this also… was hoping to get to LA from Santa Barbara; getting to Sacramento is a bit harder
Yeah I read this yesterday… a sad ending to an article that, in the first place, was discussing intrinsic issues with the university funding model. May we be so lucky to just have those intrinsic issues in a year
No despairing!!
Fight fight fight
the wide scale legal action about the NIH IDC is great.
I am concerned that there is no such action for the NSF. basic research generates long term technological/economic benefit, but the long time scale makes it vulnerable to short term budget thinking
Who is championing the NSF?
Well all the more reason to take quick action then!
Though even CRISPR was at least 15 years, and perhaps longer depending on which fundamental research paper you want to start counting from
You are right
It probably varies with sector.
Some physics things are longer scale
Agreed that biotech is much faster