Genome modelling and design across all domains of life - Evo2
A biological foundation model trained on 9 trillion DNA base pairs to predict the functional impacts of genetic variation
www.nature.com/articles/s41...
Out now! In collaboration with Leifu Chang, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems!
Links to the published articles:
tinyurl.com/55kpavet
tinyurl.com/sk6djwx3
Previous thread for the preprint:
bsky.app/profile/did:...
Fantastic collaboration w/ @dbikard.bsky.social @audeber.bsky.social @rayanchikhi.bsky.social labs led by @jmouradesousa.bsky.social : We assessed the rates of variation of anti-phage systems in P4-like satellites and P2 helper phages. Quick conclusion: Huge variation! We focus on 4 key questions/5
➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔
🧵👇
Rapid modular evolution of antiviral repertoires in P2 phages and their P4 satellites: shuttling, swapping and mixing https://www.biorxiv.org/content/10.64898/2026.02.27.708500v1
🧵 Proud to present a tour de force by postdoc @gregbwhitfield.bsky.social solving the mystery of how bacterial Tad pili can extend and retract with a single motor ATPase. Great collaboration with Lynne Howell, @dr-lori-burrows.bsky.social, @ianyyen.bsky.social www.biorxiv.org/content/10.6...
SNIPE is a widespread bacterial defence system that exploits the spatial organization of phage genome injection to specifically target viral DNA, distinguishing self from non-self in prokaryotic immune systems @nature.com @mitpress.bsky.social
www.nature.com/articles/s41...
New preprint on Detectrons from @jihoon-han.bsky.social! These are programmable biosensors for RNA that produce DNA barcodes in the presence of their target RNA. Check out Jihoon's quoted thread and the preprint for more:
www.biorxiv.org/content/10.6...
Join us at the 2026 GRC Microbial Stress Response to be held on July 19th-24th at Mount Holyoke College!! Here is the link for more information: www.grc.org/microbial-st...
🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...
Wow! Very cool.
@institutpasteur.bsky.social
Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
Also a big thanks to @cresslab.bsky.social and @therubinlab.bsky.social who came up with the idea to start this meeting and were instrumental in making it happen! And congratulations to @therubinlab.bsky.social and @paulwilmes.bsky.social for their elections as vice-chairs for the next one!
It was a true privilege to co-chair the inaugural GRC meeting on Microbiome Editing together with @jenniferdoudna.bsky.social . The positive energy and quality of the Science presented were truly inspiring. I look forward to the next one chaired by KC Huang and @omalleylab.bsky.social !!!
🦠🧫 Envie d'en savoir plus sur la Microbiologie et de découvrir l'Institut Pasteur ?
Rejoignez nous pour conférence scientifique grand public, accompagnée d’une performance artistique le 27 janvier à 18h! Inscrivez-vous :)
research.pasteur.fr/fr/event/con...
This is shaping up to be one of the top conferences on microbiome editing!!
Conference poster on microbiome editing
Such a privilege to share the Phage Foundry (phagefoundry.org) team’s work at the inaugural GRC meeting on Microbiome Editing 🎉🎊.
@francoisrousset.bsky.social, chercheur en microbiologie au @ciri-lyon.bsky.social est lauréat du Prix Paoletti 2025.
👋 @cnrs-rhoneauvergne.bsky.social
buff.ly/o9MCTni
Live microscopy to 'phollow' phage outbreaks 🔬✳️
www.nature.com/articles/s41...
Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠
www.nature.com/articles/s41...
Our new paper on DusB’s role in redox metabolism in V. cholerae is now out in @narjournal.bsky.social linking tRNAmodif enzymes and metabolic adaptation.
Beyond RNA modification: a tRNA-modifying enzyme shaping oxidative stress resilience and metabolism in V. cholerae #rnasky #rnabiology
😊🦠💫
Incredibly greatful to the EMBO for the recognition and to all my past and current colleagues @institutpasteur.bsky.social and Eligo Bioscience!
The EMBO Gold Medal 2025 was awarded to Tanmay Bharat and David Bikard: https://www.embo.org/press-releases/embo-gold-medal-2025-awarded-to-tanmay-bharat-and-david-bikard/ 🧪
At #CellBio2025, the EMBO Gold Medal was handed over to David Bikard in recognition of his pioneering work on #GeneEditing.
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
