RajuBrainLab

Check out the very important topic:
how does poverty influence childhood cancer biology and treatment response?

wonderful work from Birgit Knoechel and Kira Bona!
@huntsmancancer.bsky.social
@danafarber.bsky.social

www.biorxiv.org/content/10.6...

Can someone please respond to Stephen Miller with this message from Frank Sinatra?

Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors Nanoparticles targeted to solid tumor vasculature improve the pharmacologic properties of PROTACs.

Congrats to our team on building a technology that enables virtually all PROTAC protein degrader drugs to be delivered to tumors! “Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors” | Science Advances www.science.org/doi/10.1126/...

Congrats Daniel Heller and team on another potential game changer in the field of drug delivery!!!!
These nanoPROTACs get even more exciting in the brain space for CNS disorders! Stay tuned!
#medulloblastoma #DMG #DIPG #GBM #Ependymoma #SelectinTherapeutics
#EndPediatricBrainCancer

UC San Diego’s Collaborative Research Efforts, Community-Based Care Initiatives are in its DNA Victor Nizet, MD, discusses how students can thrive at the university’s Skaggs School of Pharmacy and Pharmaceutical Sciences. He discusses the school's features including its rigorous coursework, foc...

Thanks @contagionlive.bsky.social for letting me put in some unscripted words

UC San Diego is the ideal place to receive your dream education or pursue a faculty career in collaborative medical or pharmaceutical sciences
@ucsandiego.bsky.social
@ucsdmedschool.bsky.social
@ucsdpharmacy.bsky.social

Congrats Mimi and team!

Before coming to NIH, Collins identified the gene that is mutated in cystic fibrosis (CF). Years later, this discovery led to the development of an innovative therapy for CF that's saved countless children.

This is why we fight.

www.nejm.org/doi/full/10....

Prensner: ‘Big Beautiful Bill’ betrays children with cancer In the United States, we’ve fought to achieve the world’s best care for children with cancer.

As a #childhoodcancer doctor, I'm proud to be able to advocate for children with cancer in any way that I can.

Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it.

#PEDCan
#CANSky

www.detroitnews.com/story/opinio...

This rapid action by the Prebys Foundation is the kind of thing I hope other regional philanthropies are doing. It isn't the entire solution by far but it is great to see them chipping in to help investigators in the San Diego academic science community.

www.prebysfdn.org/stories/blog...

How Health Care Remade the U.S. Economy (Gift Article) Medicine is now the nation’s largest employer, but its growth may be slowing.

Beyond taking #healthcare away from millions of kids, families, and the elderly, the Budget-Busting Bill would mean the loss of thousands of jobs in hospitals, research centers, nursing homes, clinics, doctors’ offices.
www.nytimes.com/interactive/...

“I represent 67,000 pediatricians, and let me be clear: this bill will devastate children’s health,” said Dr. Susan Kressly, President of @ameracadpeds.bsky.social “Kids are 22% of our population—but 100% of our future. We cannot afford to fail them.”
Call your senators and demand a NO vote.

The Catch in Catching Cancer Early New blood tests promise to detect malignancies before they’ve spread. But proving that these tests actually improve outcomes remains a stubborn challenge.

The promise and problems with multi-cancer early detection tests
by Sid Mukherjee @newyorker.com
www.newyorker.com/magazine/202...

Nice to see this important translational hurdle- crossing the BBB- highlighted in Nature! Of note is the point that it would be ideal to not only cross the BBB, but deliver therapeutics specifically to the CNS site of disease which current brain shuttles don’t do. Stay tuned:) #SelectinTherapeutics

The pivot penalty in research - Nature An analysis of millions of scientific papers and patents reveals a ‘pivot penalty’ when researchers shift direction, with the impact of studies decreasing rapidly the further they move from their previous work.

Nature research paper: The pivot penalty in research

https://go.nature.com/4dDz2bL

Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer - Nature Cancer Based on a proteogenomic analysis, Perreault and colleagues report that the majority of predicted tumor antigens originate from unmutated genomic sequences in melanoma and non-small cell lung cancer.

Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer
www.nature.com/articles/s43...

My quote of the day

If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong.

Arthur C. Clarke

CBTN offers pediatric brain tumor data and samples to researchers worldwide for free. Request these resources to accelerate discoveries for kids: https://monkeylink.co/5c6c96

#WeAreCBTN #OpenScience

Cuts to NIH funding have dire consequences!

Neuroscience Professor Robert Greene shares why efforts to treat brain disease will suffer due to recent changes in U.S. government policies.

#Neurosky #AcademicChatter

Medicaid Covers

• 42% of all children nationwide
• 77% of children living in poverty in the U.S.
• 44% of children and youth with special health care needs nationwide
• 41% of births in the U.S.
• 37% of U.S. children with cancer
• 99% of children and youth in foster care

A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors. https://www.biorxiv.org/content/10.1101/2025.04.29.651335v1

Cell classification should be based on more than just DNA

Fumiko Ladd Chino: Toxicity in phase III oncology clinical trials is often incompletely reported - OncoDaily Fumiko Ladd Chino: Toxicity in phase III oncology clinical trials is often incompletely reported / Adina H Passy, Alexander D. Sherry, Avital M Miller,

Toxicity in phase III oncology clinical trials is often incompletely reported - Fumiko Ladd Chino
@fumikochino.bsky.social

oncodaily.com/opinion/fumi...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews

This bottleneck in research funding threatens research that took decades to build, as well as the cures of tomorrow. Publicly-funded research is the highest economic yield there is, with 2.5X of economic gains for every $.

Call your Senator and Rep to ask them to protect federal research!

The NIH grant that has supported 38 years of training the best pediatrician-scientists in the country (I’m a proud former recipient) was cancelled. It was just approved for a 5 year renewal. The PSDP has supported the careers of many NIH-funded pediatrician-scientists and thought leaders

We need more support now, not less, to train the next generation of pediatric-scientist leaders to give them the needed runway to develop novel therapies that will significantly impact the health and outcomes of children and their families.

This is a really disappointing decision by the NIH to cancel the longstanding Pediatric Scientist Development Program (PSDP-K12) grant that has funded the early career development of numerous pediatric physician-scientists who have become the pediatric leaders in the US and the world.

Pediatric research. When grants are pulled, the infrastructure suffers
www.wcvb.com/article/bost...

A kindergartner’s hopes for beating cancer are tied to federal grants now on the chopping block | CNN A family whose 6-year-old is battling cancer says a move to slash funding by the National Institutes of Health (NIH) for research at universities and medical centers would be “devastating.”

On the front page of @cnn.com is a feature on how #NIH funding cuts might impact #childhoodcancer. Thanks to MJ Lee for spotlighting this issue, and I was glad to be able to contribute.

These kids deserve the best, not cuts!

#CANSky
#PEDSky

www.cnn.com/2025/02/25/h...

Who benefits from US funding uncertainty? Hours after posting this, I got an email inviting me to China with a “package to support my research for 20 years.” Apparently, generous offers are available to all good scientists!🧪🧠

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

American science is under attack

Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪

“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”

www.nytimes.com/2025/02/14/o...