The Lancet Gastroenterology & Hepatology

Announcing The Lancet Medical Imaging & Theranostics. A new open access journal dedicated to clinical and technological advances in radiology, nuclear medicine, and theranostics. Artwork: Abstract medical image of a torso with vibrant organic shapes and geometric patterns, suggesting medical imaging. Credit: Shonagh Rae.

Introducing our new #goldopenaccess journal on medical imaging and theranostics!

Learn more about the journal’s mission and explore related content from The Lancet Group today: spkl.io/63324As4V2

🆕Our March issue is live!

📊Articles: #prostatecancer, #breastcancer, #melanoma, and #brachytherapy

📰Reviews: #ESTRO concensus on RT for more efficacious novel anticancer drugs + a expert consensus on oligometastatic pancreatic cancer

www.thelancet.com/issue/S1470-...

Promotional card. Contact Ali Landman regarding content enquiries at allison.landman@lancet.com. Copyright: Elsevier Ltd.

Our Editor-in-Chief, Ali Landman, will be at #ECR2026 in Vienna, March 4-8, and she invites you to reach out with any questions about the journal or if you'd like to discuss your research.

Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q042qY8P0

Our March 2026 issue is live!

Including research in individuals at risk of developing arthritis, real-world data on anifrolumab in #SLE, #cardiovascular risk in #APS, and childhood-onset Sjögren's disease, plus much more! thelancet.com/journals/lan... #Rheumsky

Cover by @emma-cheng.bsky.social

Voices from the frontline: how global funding cuts are reshaping the viral hepatitis response Hepatitis B virus (HBV) and hepatitis C virus (HCV) are among the world's leading infectious threats, together responsible for over a million deaths each year, but these infections remain neglected by...

Lots of focus on the impact of #funding cuts on #HIV but there are wider repercussions.
Here we report 'Voices from the frontline: how global funding cuts are reshaping the viral #hepatitis response' 🧪
@lancetgastrohep.bsky.social @worldhepalliance.bsky.social
www.thelancet.com/journals/lan...

Tran concludes that additional molecular information provided by the molecular medicine board significantly improved therapy outcomes

#ECCO2026 #ECCO26 #GastroSky #IBDSky

Florian Tran presents results from GUIDE-IBD, a trial using an RNA-based biomarker to inform therapy guidance for patients with IBD initiating infliximab

#ECCO2026 #ECCO26 #GastroSky #IBDSky

Just presented at #ECCO2026 - 10-year data from the LIR!C trial comparing ileocaecal resection vs infliximab for ileal Crohn’s disease

Now published in @lancetgastrohep.bsky.social

www.thelancet.com/journals/lan...

#ECCO26 #GastroSky #MedSky #IBDSky

Safety, pharmacokinetics, and preliminary efficacy of VS-01, an intraperitoneal liposomal infusion, in patients with decompensated liver cirrhosis, ascites, and covert hepatic encephalopathy: a phase ... VS-01 was generally well tolerated with a favourable safety profile in patients with decompensated liver cirrhosis, ascites, and covert hepatic encephalopathy. The results of this study supported the ...

New research - Safety, pharmacokinetics, and preliminary efficacy of VS-01, an intraperitoneal liposomal infusion, in patients with decompensated liver cirrhosis, ascites, and covert hepatic encephalopathy: a phase 1b study

www.thelancet.com/journals/lan...

#LiverSky #MedSky

Making room under the umbrella for microscopic colitis Microscopic colitis, a condition causing chronic inflammation in the colon, comprises collagenous colitis and lymphocytic colitis. But is microscopic colitis inflammatory bowel disease (IBD)? A medica...

Very happy to share this Feb commentary in @lancetgastrohep.bsky.social co-authored w @mayoclinic.org #IBD Dr. Edward V. Loftus Jr. - making our case for an urgent repositioning of #microscopiccolitis under the "true" #IBD umbrella - long overdue for this disease.

www.thelancet.com/journals/lan...

Our March issue is now live at www.thelancet.com/gastrohep!

Content includes: #alcohol, #IBD, #HBV, #MASLD, #SIMD (#SIBO) + more!

#GastroSky #LiverSky #MedSky

Figure showing an overview of VEXAS syndrome. The clinical phenotype is expanding and the pathobiology of some manifestations have been elucidated. VEXAS=vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic.

VEXAS syndrome is a newly discovered multisystemic disease affecting most organs.

A Review provides a comprehensive overview of VEXAS syndrome, including the disease's discovery, diagnosis, and treatment: spkl.io/63322AsNa8

🚀 Just launched – our new #goldopenaccess journal on medical imaging and theranostics!

Learn more about the journal’s mission and explore related content from The Lancet Group today: hubs.li/Q041CgFF0 #medsky @lancetimaging.bsky.social

February Issue of The Lancet Public Health is Live. This month sees an array of PH topics:

♥️ Cardiovascular Disease 🇪🇺
🧬 Diabetes 🇲🇽
🧸 Child protective services 🇨🇦
🩵 Cervical cancer 🇦🇺
🧫 Tuberculosis - 🇨🇦 and 🇦🇺
🍱 School meal programmes 🇪🇺

Click to find out more:
www.thelancet.com/issue/S2468-...

New World Report in @thelancet.com examines the controversial trial of hepatitis B virus birth dose vaccination that was planned in Guinea-Bissau

#HepSky #LiverSky #IDSky

Efimosfermin alfa (BOS-580) once per month in people with metabolic dysfunction-associated steatohepatitis with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled,... In this phase 2 trial, treatment with efimosfermin once per month was generally well tolerated in participants with biopsy-confirmed MASH and F2 or F3 fibrosis. These results support the further devel...

New @thelancet.com - Efimosfermin alfa (BOS-580) once per month in people with MASH with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial

www.thelancet.com/journals/lan...

#LiverSky #MedSky #EndoSky #GastroSky

Announcing The Lancet Medical Imaging & Theranostics. A new open access journal dedicated to clinical and technological advances in radiology, neuclear medicine, and theranostics. Artwork: Abstract medical image of a torso with vibrant organic shapes and geometric patterns, suggesting medical imaging. Credit: Shonagh Rae

🚀 Just launched – our new #goldopenaccess journal on medical imaging and theranostics!
Learn more about the journal’s mission and explore related content from The Lancet Group today: hubs.li/Q041CgFF0

#medsky

New research: Long-term oncological outcomes following algorithm-based vs usual care for the early recognition & management of complications after pancreatic resection: post-hoc analysis of a stepped-wedge cluster-randomised trial

www.thelancet.com/journals/lan...

#GastroSky #OncSky #MedSky

Figure summarising the mechanisms of action targeted for MASH therapy. MASH=metabolic dysfunction-associated steatotic liver disease. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease.

In @lancetgastrohep.bsky.social, a Review summarises recent breakthroughs and potential future developments: spkl.io/63323Aq7BR

Read our February issue!

Featuring long COVID after reinfection in children and adolescents, testing the MAM01 monoclonal antibody for malaria, and household transmission dynamics of mpox in Burundi.

www.thelancet.com/issue/S1473-...

Safety and immunogenicity of a conjugate vaccine candidate against Salmonella enterica serovars Typhi and Paratyphi A in healthy adults in Europe: a phase 1 randomised controlled trial Vi-CRM197+O:2-CRM197 formulations did not raise safety concerns and showed immunogenicity with a single dose, supporting further clinical assessment of the full-dose without aluminium hydroxide in tar...

New Research

Safety and immunogenicity of a conjugate vaccine candidate against Salmonella enterica serovars Typhi and Paratyphi A in healthy adults in Europe: a phase 1 randomised controlled trial

www.thelancet.com/journals/lan...

NEW RESEARCH—Long-term outcomes of abatacept in individuals at risk of developing rheumatoid arthritis (ALTO): a randomised, double-blind, placebo-controlled trial bit.ly/4pSERqq

Plus, linked Comment bit.ly/49v27Ga #Medsky #Rheumsky

January cover of The Lancet Microbe

Our January issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #influenza #H5N1 #AMR #Bordetella #pertussis #Yaws #Treponema #MDA #Hpylori #SARS-CoV-2

#IDSky #ClinMicro #OA

Safety and efficacy of CRS3123 in adults with a primary episode or first recurrence of Clostridioides difficile infection: a phase 2, randomised, double-blind, multicentre, vancomycin-controlled study Both doses of CRS3123 were deemed safe and well tolerated and showed efficacy similar to vancomycin at the TOC visit, with lower rates of recurrence. Together, these data support further development o...

New Research

Safety and efficacy of CRS3123 in adults with a primary episode or first recurrence of Clostridioides difficile infection: a phase 2, randomised, double-blind, multicentre, vancomycin-controlled study

www.thelancet.com/journals/lan...

‘It’s the sovereignty of the country’: Guinea-Bissau says US vaccine study suspended Despite US pushback, officials in west Africa say controversial hepatitis B study on pause amid ethics concerns

"Africans want to solve Africa’s problems, not satisfy the curiosity of the funders."

www.theguardian.com/world/2026/j...

ASCO Gastrointestinal Cancers Symposium 2026 A prespecified interim analysis of HERIZON-GEA-01 indicates that zanidatamab—a dual HER2-targeted monoclonal antibody that crosslinks neighbouring HER2 receptors and causes receptor clustering—might b...

News - ASCO Gastrointestinal Cancers Symposium 2026

www.thelancet.com/journals/lan...

#GI26 #ASCOGI #GastroSky #OncSky #MedSky

Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised contr... C-EEN was superior to PEN in maintaining clinical remission over 1 year in paediatric patients with Crohn's disease responding to EEN induction therapy. These findings suggest a new way to use nutriti...

New research - Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised controlled trial

www.thelancet.com/journals/lan...

#GastroSky #MedSky #IBDSky

ALG-000184 (pevifoscorvir sodium) monotherapy in participants with chronic HBV infection: a phase 1, multicentre, randomised, dose escalation trial ALG-000184 was safe and well tolerated, demonstrated predictable pharmacokinetic properties, and reduced HBV DNA and HBV RNA at all doses regardless of HBeAg status. These results support the evaluati...

New research - ALG-000184 (pevifoscorvir sodium) monotherapy in participants with chronic HBV infection: a phase 1, multicentre, randomised, dose escalation trial

www.thelancet.com/journals/lan...

#HepSky #IDSky #LiverSky #MedSky

Controversial CDC-Funded Hep B Study Halted An official from the Africa CDC said if it moves forward, it must meet ethical criteria

Controversial CDC-Funded Hep B Study Halted www.medpagetoday.com/infectiousdi...

New Comment - Menopause and inflammatory bowel disease: more questions than answers

www.thelancet.com/journals/lan...

#GastroSky #MedSky #IBDSky