SattelyLab

Immunodominant epitopes from seed storage proteins are a target of intestinal regulatory T cells that modulate immune challenge to food @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @sattelylab.bsky.social @stanforduniversity.bsky.social

Paclitaxel saved my life. New discoveries could boost supply After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug

Lovely C&EN @cenmag.bsky.social story on the history and personal impact of the cancer drug Taxol. After spending recent years deciphering how yew trees, our source for Taxol, synthesize this lifesaving drug, it’s so nice to see it in the larger context #secmet #medsky
Plants are amazing chemists.

We like to make our science open access to everyone. A preprint server provides the pre-edited manuscript without a paywall. #openscience

It was a wonderful meeting - one of my highlights of 2025. Thank you to the organizers: @sattelylab.bsky.social, @beckybart.bsky.social, and Cyril Zipfel

Sattely Research Group @ Stanford Explore plant chemistry research at Sattely Group, focusing on plant chemistry for agriculture and human health innovations.

We are live!
Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org

Thanks to Dr. Cassandra Quave for hosting me on her Foodie Pharmacology podcast!

We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!

t.co/nEdpoyN8QD

Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...

Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1

Congrats Guillermo! Fantastic finish to his ChemE REU program participation

Congrats, Jack, for a successful PhD defense🎉Party, T-shirt exchange, and a self-made Piñata

Most recent group photos! So many celebrations🥳

Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology

Watch out for @taralowensohn.bsky.social at the GRC for Single-Cell Approaches in Plant Biology. She will be giving a talk about the pooled gene perturbation and protoplast sorting technologies developed in the lab. Interested? Talk on Monday at 8.10 pm. #grc #singlecell #plants #plantbiology

The Blum lab is recruiting graduate students and postdocs! Grad students: Reach out to me if you're interested in a rotation! Postdoc candidates: recruiting2.ultipro.com/SAL1013SIBS/...

Congrats!

Pithy coverage by @plantaeofficial.bsky.social of our recent Taxol work

#chemsky #medsky

New insights in plant gene research could boost cancer drug production A novel approach to analyzing yew tree genes has revealed key enzymes used to make Taxol, a chemotherapy drug that’s long been difficult and costly to produce.

Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol

@sattelylab.bsky.social news.stanford.edu/stories/2025...

Thanks to @frankelab.bsky.social 🌱

Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol

Biochemical breakthrough paves way to reliable supply of anticancer drug ‘Missing’ genes needed for the biosynthesis of a natural anticancer drug have been discovered by perturbing and analysing individual cells of yew trees.

Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology

Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!

Working in science is particularly challenging these days, but hopefully, your plants offer a daily dose of joy. #plants

Congrats @caseyvchan.bsky.social to a successful Qual exam!!!😀

The 1st Annual Bay Area Plant Hub recently concluded, and it was a resounding success! We thoroughly enjoyed connecting with everyone. Hope you had a chance to stop by @caseyvchan.bsky.social 's and @taralowensohn.bsky.social 's posters. Plus listen to an intriguing discussion with Beth and others 🌱

🌱 Elizabeth Sattely, Stanford Chemical Engineering professor, explores how plants turn CO2 & sunlight into molecules that boost resilience & human health. Her work aims to create crops resilient to climate change & disease, improving global food systems. #SustainableAgriculture 🌍🍃