Gladstone Institutes

Jennifer Doudna’s journey from student to scientist and mentor The 2026 Priestley Medalist and Nobel laureate struggled with finding her way through school before achieving the greatest feats in science

Gladstone Investigator Jennifer Doudna, the 2026 Priestley Medalist, shares how she struggled to find her way through school before achieving the greatest feats in science.

Happy Employee Appreciation Day to the incredible team at Gladstone! 🎉

Every discovery, breakthrough, and bold idea starts with you. Your dedication, collaboration, and curiosity drive our mission forward every single day.

At High Altitudes, Red Blood Cells Absorb Excess Sugar, Offering Protection In the highest reaches of our planet, where the air is thin and oxygen is scarce, residents enjoy a remarkable health advantage: a significantly lower incidence of diabetes. This long-observed but

Why is diabetes less common at high altitudes?

New research from Gladstone uncovers how low oxygen levels trigger an unexpected metabolic role for red blood cells—revealing a key mechanism behind this long-observed protection.

HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV - Nature Communications HIV-transcribing cells in people living with HIV are difficult to study with conventional single-cell RNA-seq. Here the authors develop a technique to increase detection of HIV RNA during scRNA-seq an...

🚨NEW PUBLICATION🚨 "HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV"

@natcomms.nature.com
@thedohertyinst.bsky.social

Virologist Viewpoints: For HIV, ‘Manageable' Is No Longer Good Enough Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS.

Antiretroviral therapy transformed #HIV care—now we need a cure. Insights from Melanie Ott on what comes next.

New Tool Reveals the Secrets of HIV-Infected Cells Developed by Gladstone scientists, HIV-seq could uncover new opportunities for treating HIV.

A team of scientists developed a novel tool, named HIV-seq, that could uncover new opportunities for treating #HIV.

SLAS2026 award winners announced  - Drug Discovery World (DDW) Award winners at the SLAS2026 conference have been announced, with the event attracting a record number of attendees.

Steve Finkbeiner, director of the Center for Systems and Therapeutics, was selected as the recipient of the 2026 Innovation Award by the Society for Laboratory Automation and Screening for his work on AI, robotics, and the thinking microscope.

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Vitamin B3 Therapy Offers Hope for Fatal Childhood Disease A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.

Children with NAXD deficiency typically die within their first few months of life. @gladstoneinst.bsky.social scientists reported in @cellpress.bsky.social that vitamin B3 therapy extended lifespan more than 40-fold in mice and eliminated symptoms.
gladstone.org/news/vitamin...

Final week to apply!

PUMAS is designed specifically for community college students ready to gain hands-on research experience at Gladstone.

Don’t miss this opportunity to spend your summer in the lab learning from world-class scientists.

Apply now ➡️ https://bit.ly/2UVIaST

People who live at high altitudes—where oxygen levels are lower—are less likely to develop diabetes than those at sea level. Now, researchers have uncovered why, and their discovery could help pave the way for new treatments.

Health Tech: Deepak Srivastava Of Gladstone Institutes On How Their Technology Can Make An… This convergence of AI, stem cell biology, and gene editing means that we no longer have to accept our genetic destiny. For the first time…

Gladstone president Deepak Srivastava is featured in Authority Magazine discussing how technology is transforming the future of medicine.

Portfolio — Hypothesis Fund The Hypothesis Fund enables scientists to take intelligent risks. To defy the predominant expectations in their field. To go after their big ideas.

Gladstone researcher Sukrit Silas is a 2026 Hypothesis Fund awardee. Silas is setting out to solve the longstanding challenge of predicting phage-bacteria compatibility. His project could transform how phages are harnessed to fight against antibiotic resistance.

Discovery Spotlight | Red Blood Cells Soak Up Sugar at High Altitude, Protecting Against Diabetes YouTube video by Gladstone Institutes

A new study, led by @ishahjain.bsky.social, shows red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.

Cell Signals│Red Blood Cells Soak Up Sugar at High Altitude, Protecting Against Diabetes Plus, learn how Gladstone scientists are creating AI tools to accelerate life-saving discovery.

In our latest issue of Cell Signals, discover how red blood cells absorb glucose at high altitude to offer potential protection against diabetes, learn how Gladstone scientists are creating AI tools to accelerate life-saving discovery, and watch a behind-the-scenes video of a student intern.

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

🚨 🚨 NEW PUBLICATION 🚨 🚨 "Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease"

@arcinstitute.org
@ishahjain.bsky.social
@cp-cell.bsky.social

Vitamin B3 Therapy Offers Hope for Fatal Childhood Disease A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.

A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.

@arcinstitute.org
@ishahjain.bsky.social
@cp-cell.bsky.social

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

vitamins!!!! They cure disease! Amazing work (again!) from @ishahjain.bsky.social's lab here at @gladstoneinst.bsky.social (and @arcinstitute.org) www.cell.com/cell/fulltex...

PUMAS Summer Internship Program | Gladstone Institutes PUMAS is Gladstone's flagship internship program designed to support and mentor community college students, providing them with hands-on research experience and a pathway into the sciences.

Each summer, Gladstone welcomes a cohort of community college students to work in a Gladstone lab, alongside a scientific mentor.

Become an integral part of the team and contribute to projects focused on stem cells, machine learning, and other areas central to understanding and treating disease.

From Hiking Trails to the Lab: Discovering New Retrons YouTube video by Gladstone Institutes

Kazuo Nakamura joined Gladstone as a student intern in the lab of @seth-shipman.bsky.social, where he set out to search for retrons—bacterial defense mechanisms that scientists can harness for genome editing.

What began as a teaching project quickly turned into real discovery.

Congrats, Nadia!

RBCs are not passive bystanders in systems metabolism. We had been saying this for years. This time, in collaboration with Isha Jain @gladstoneinst.bsky.social

By the way, the Jain lab is on a roll, with ever more elegant science at each paper. It was a pleasure to collaborate!

Red Blood Cells Soak Up Sugar at High Altitude, Protecting Against Diabetes New study shows red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.

People living at high altitude have less diabetes. A new study by @gladstoneinst.bsky.social @ishahjain.bsky.social shows why: In low-oxygen conditions, red blood cells soak up sugar from the bloodstream. A drug mimicking this effect reversed high blood sugar in mice.
gladstone.org/news/red-blo...

Join us for the next Infectious Diseases & Human Health Symposium by @gladstoneinst.bsky.social and QBI: "Sex Differences in Immunity and Diseases" on February 27!

Learn more & register: qbi.ucsf.edu/sex-differen...

The challenges scientists face are so complex that they’re nearly impossible to solve without advanced computational tools. #AI helps uncover hidden patterns in massive datasets—patterns that can spark new hypotheses, reveal insights, and even predict what might happen next.

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude Martí-Mateos et al. show that red blood cells explain improved glucose tolerance at high altitude. By manipulating red blood cell number, they determine that these cells are necessary and sufficient f...

🚨 NEW PUBLICATION 🚨 "Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude"

@ishahjain.bsky.social
@dalessandrolab.bsky.social
@medschool.umaryland.edu
@cp-cellmetabolism.bsky.social
@arcinstitute.org

Getting to the heart of atrial cardiomyocyte identity Cardiomyocytes (CMs) of the heart's atria and ventricles have different functions and developmental origins, and common cardiac defects affect each chamber specifically. However, the gene regulatory networks (GRNs) that govern their identities are uncle...

Check out this research highlight in Development spotlighting new work from @irfankathiriya.bsky.social and @benoitbruneau.bsky.social

Gladstone Scientist Nadia Roan Elected to American Academy of Microbiology Roan has made great strides in understanding how persistent viruses including HIV cause disease and how immunity to viruses shapes human health.

Nadia Roan, a pioneer in the fight against some of the world’s most persistent viruses, has been elected as a 2026 Fellow of the American Academy of Microbiology.

Go behind the scenes of an on-screen interview with Gladstone scientist Julia Kaye. Julia studies neurodegenerative diseases like ALS, Parkinson’s, and Huntington’s—and collaborates with researchers across the country to analyze the genomes of thousands of ALS patients.