Huang, Fei-Yang (黃飛揚)

Agouti integrates environmental cues to regulate paternal behaviour - Nature Expression of agouti signalling protein in neurons in the medial preoptic area is increased by group housing and negatively associated with care, and overexpression of Agouti reduces care and enhances...

Why are some males caring toward infants while others are neglectful or abusive? I'm so pleased to share work that my colleagues and I @princeton.edu have just published @nature.com (an explanatory thread to follow!) (1/8)

TFUS mechanism, redux. Recent papers show TRPC6 mechanosensitive ion channels in cultured mouse neurons (DOI: 10.1073/pnas.2404877121), a way tFUS might interact with the brain. And yet TRPC6 is also a major player in vascular (myogenic) tone. Ignore vessels at your peril, tFUS folks!

Insular cortex predictions regulate glucose homeostasis Brain-body interactions are essential for physical and emotional homeostasis. The brain uses information from the external world to predict upcoming bodily changes. This process involves interoceptive...

lab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD.. www.biorxiv.org/content/10.6...

Delighted we made the superlab list @andpru.bsky.social 🫶

List: mailchi.mp/c9edb773c735...

Paper: www.nature.com/articles/s41...

Petition to end primate research presented to German Parliament Representatives from PETA and Doctors Against Animal Experiments presented to the petition committee of the German Parliament on 1 December, calling for a phased EU-wide end to primate research.

Petition in Germany with 40,000 signatures calls for a phased EU-wide end to primate research. EARA stresses that #NHP studies remain vital for developing treatments and vaccines and warning against politically driven restrictions before alternatives are ready. www.eara.eu/post/petitio...

🧠📢 New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵

#neuroskyence #compneurosky

The special issue celebrating John Duncan's retirement is now out! Check out all the gem articles here:
sciencedirect.com/special-issue/10QN6R7VQSM

and the editorial (see next figure in the thread for an entertaining analysis)
doi.org/10.1016/j.ne...

Effects of eye closure on the spiking activity of human lateral geniculate neurons - Nature Communications The LGN is a critical stage between the retina and visual cortex, but the properties of human LGN neurons are not fully understood. Here the authors report that they closely resemble those in monkeys ...

Our paper showing the first ever recordings of spiking activity from neurons in the human lateral geniculate nucleus has just been published in Nature Communications! Congrats to the whole team. #neuroskyence @nin-knaw.bsky.social @uofgpsychneuro.bsky.social
www.nature.com/articles/s41...

📍Excited to share that our paper was selected as a Spotlight at #NeurIPS2025!

arxiv.org/pdf/2410.03972

It started from a question I kept running into:

When do RNNs trained on the same task converge/diverge in their solutions?
🧵⬇️

Our next paper on comparing dynamical systems (with special interest to artificial and biological neural networks) is out!! Joint work with @annhuang42.bsky.social , as well as @satpreetsingh.bsky.social , @leokoz8.bsky.social , Ila Fiete, and @kanakarajanphd.bsky.social : arxiv.org/pdf/2510.25943

🚨Please join us today (Monday 11/17) at 4pm in Room 4 to #AskAnything to Editor-in-Chief of Journal of Neuroscience @sfnjournals.bsky.social Dr. Sabine Kastner about scientific publishing and our board! Early career researchers are especially welcome! @sfn.org
#Sfn2025 #SfN25

@ibroorg.bsky.social @wellcometrust.bsky.social @oxexppsy.bsky.social

I am happy to share that I have received #IBRO & #SfN travel award to present my research at #SfN2025!

Feel free to reach out for any discussions and hope to see you at the two poster sessions on Sat & Mon!

#neuroscience #training #grant #award #IBROinEurope

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

New review on neural manifold and population activity in the brain-
www.nature.com/articles/s41...

Phantom oscillations in principal component analysis | PNAS Principal component analysis (PCA) is a dimensionality reduction method that is known for being simple and easy to interpret. Principal components ...

To be clear, have not been able to read the original study because the link does not work. HEre is a fun paper on fourier. www.pnas.org/doi/10.1073/...

3 UCLA faculty members elected to the National Academy of Medicine UCLA neurologist S. Thomas Carmichael, lung specialist Paul W. Noble and public health pioneer Ninez A.

Congrats 🎉 Tom Carmichael for your groundbreaking contributions to our knowledge and treatment of stroke… (but not mentioned anywhere is the foundational macaque PFC neuroanatomy) stemcell.ucla.edu/news/3-ucla-...

Happy Taiwan National Day from London!

Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...

New in @pnas.org: doi.org/10.1073/pnas...

We study how humans explore a 61-state environment with a stochastic region that mimics a “noisy-TV.”

Results: Participants keep exploring the stochastic part even when it’s unhelpful, and novelty-seeking best explains this behavior.

#cogsci #neuroskyence

"Cognition is emergent" by Earl Miller YouTube video by Neuroscience & Philosophy Salon

Talk: Cognition is Emergent - Earl K. Miller
Neuroscience and Philosophy Salon, 9-12-25
youtu.be/Sk4ehOcsDmM?...

🚀Excited to share our project: Canonical Representational Mapping for Cognitive Neuroscience. @schottdorflab.bsky.social and I propose a novel multivariate method to isolate neural representations aligned with specific cognitive hypotheses 🧵https://www.biorxiv.org/content/10.1101/2025.09.01.673485v1

Amygdala–liver signalling orchestrates glycaemic responses to stress - Nature Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independen...

Amygdala–liver signalling orchestrates glycaemic responses to stress
www.nature.com/articles/s41...

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors - Nature Neuroscience The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuati...

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors

www.nature.com/articles/s41...

Last call: why is China sobering up? Our weekly podcast on China. This week, why the country’s alcohol business is getting hammered

“You’ll need to make sure that your glass is held lower than the others when toasting.”

Jiehao Chen and @CrossleyGabriel consider drinking etiquette in China, on “Drum Tower”

New Dispatch in @currentbiology.bsky.social w/ @RobinPiquet & @dryacinetensaouti.bsky.social highlighting elegant work from the @iordanova.bsky.social lab that formally disentangles whether dopamine signals reward prediction errors or value.

authors.elsevier.com/a/1ldGk3QW8S...

Xiao-Jing Wang outlines the future of theoretical neuroscience Wang discusses why he decided the time was right for a new theoretical neuroscience textbook and how bifurcation is a key missing concept in neuroscience explanations.

And a podcast at Brain inspired www.thetransmitter.org/brain-inspir...

Opinion | The Future of AI Lies in Monkeys, Not Microchips Neuroscience research on primates will help us learn how to build an efficient thinking machine.

Very timely and insightful OpEd by Prof. Cory Miller on WSJ. It lays out an important point - Advanced AI cannot be developed in a vacuum without understanding the sophisticated machines we have in our brains.
www.wsj.com/opinion/the-...

Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates by Marco Ghibaudi, Chiara La Rosa, Nikita Telitsyn, Jean-Marie Graїc, Chris G. Faulkes, Chet C. Sherwood, Luca Bonfanti Structural changes involving new neurons can occur through stem cell-driven neurogenesis, and through incorporation of late-maturing “immature” neurons into networks, namely undifferentiated neuronal precursors frozen in a state of arrested maturation. The latter have been found in the cerebral cortex and are particularly abundant in large-brained mammals, covarying with the size of the brain and cortex. Similar cells have been described in the amygdala of some species, although their features and interspecies variation remain poorly understood. Here, their occurrence, number, morphology, molecular expression, age-related changes, and anatomical distribution in amygdala subdivisions were systematically analyzed in eight diverse mammalian species (including mouse, naked mole rat, rabbit, marmoset, cat, sheep, horse, and chimpanzee) widely differing in neuroanatomy, brain size, life span, and socioecology. We identify converging evidence that these amygdala cells are immature neurons and show marked phylogenetic variation, with a significantly greater prevalence in primates. The immature cells are largely located within the amygdala’s basolateral complex, a region that has expanded in primate brain evolution in conjunction with cortical projections. In addition, amygdala immature neurons also appear to stabilize in number through adulthood and old age, unlike other forms of plasticity that undergo marked age-related reduction. These results support the emerging view that large brains performing complex socio-cognitive functions rely on wide reservoirs of immature neurons.

Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates @PLOSBiology.org

Flexible updating of reward and punishment contingencies by VTA GABA neurons In dynamic environments where stimuli predicting reward or punishment unexpectedly change, it is critical to flexibly update behavior while preserving…

New lab paper by @merridee.bsky.social identifying a novel role for VTA GABA neurons in behavioral flexibility

GABA, but not dopamine, neuron activation correlates with behavior when cues unexpectedly shift from predicting punishment to predicting reward www.sciencedirect.com/science/arti...