This is such an exciting project to be a part of with my new office-neighbour @yhcarolyang.bsky.social in @lsiexeter.bsky.social. Spread the word and let's find the ideal colleague to join us for this fully funded #PhD studentship!

Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances!

www.science.org/doi/10.1126/...

Are animals of different sizes made of the same cell types?

Here’s an update of the main points and revision items

(with memes!)

Thread 👇🧵

Are you a Biophysicist who would like to work in an interdisciplinary institute? Then do not miss this opportunity. More information on the LSI website: www.exeter.ac.uk/research/ins...

Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter Opportunity for LSI PHD studentship – starting in September 2025 or January 2026 PhD Studentship applications will open on 1st...

#PhD available with @surfinnurd.bsky.social & me: physics, stem cell bio, struct bio & bioinformatics will reveal molecular changes which activate a major chromatin remodelling protein at microsecond resolution -> control activity in stem cells & control cell fate lsi.exeter.ac.uk/groups/hendr...

Huge congratulations to Heather Bottomley for passing her PhD viva yesterday! 🎉 Many thanks to examiners Vicki Gold & Glenn Masson whose expertise spanned #HDX and #CryoEM

Why is this important?
For meta-stable, #IDPs this resolves the previously perceived issue of those proteins breaking the apparent maximum chemical rates. So, we’re one step closer to being able to integrate HDX experiments and molecular dynamics simulations in a fully quantitative manner.

What have we found?
Using millisecond #HDX mass spectrometry experiments we show that the most accurate rate calibrations are achieved by using the fully unstructured 3-Ala as reference (not PDLA, which is common).

Recalibrating Protection Factors Using Millisecond Hydrogen/Deuterium Exchange Mass Spectrometry Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful technique to interrogate protein structure and dynamics. With the ability to study almost any protein without a size limit, includi...

Part of our ongoing study to advance #HDX #massspec as an absolute measurement now published! doi.org/10.1021/acs....
Great work by Michele Stofella, Neeleema Seetaloo and Alex S., co-led by Emanuele Paci, myself and @franksobott.bsky.social

Join our dynamic research team! Fully funded #PhD to engineer biosensors with AI protein design + #HDX + structural biology + biophysics. With @nicharmer @lsiexeter.bsky.social @petercook @mrccmm.bsky.social @exetercomms.bsky.social @dstl
Deadline 28th Feb!
www.surrey.ac.uk/bbsrc-wessex...

HDX-MS can reveal enzyme structural dynamics to guide molecular engineering

Join our dynamic research team! Fully funded #PhD to engineer genome editing enzymes from #HDX mass spec data-driven movies + mathematical models + AI protein design @lsiexeter.bsky.social Deadline 10th Jan
www.exeter.ac.uk/research/liv...