Kuchroo Lab

By reprogramming the tumor microenvironment with an engineered virus, @quintanalabhms.bsky.social boost anti-tumor immunity against glioblastoma.
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...

🔔 New episode alert!

Dr. Ana Anderson from Harvard Medical School talks about her work on #ImmuneRegulation in cancer.

▶️ https://bit.ly/4pJvw4u

Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School!

Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.

Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...

Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner

#neuroscience #neuroskyence

www.nature.com/articles/s41...

Beautiful work!

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...

The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.

Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...

Another 🌏 #KuchrooLabReunion in Kyoto with Norio Chihara, VKK, & Kimitoshi Kimura 🇯🇵

Neuropeptide signalling orchestrates T cell differentiation - Nature RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.

Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"

www.nature.com/articles/s41...

We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇

#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari

This conference is going to be great!
Looking forward to it.

This conference is going to be great! Looking forward to it.

Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com.
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...

REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...

New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…

Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...

Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA

Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses a regulatory progr...

The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity.
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social
www.cell.com/cell-reports...

Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!

(1/6) Our latest paper in ‪@cp-cellhostmicrobe.bsky.social‬ shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
www.cell.com/cell-host-mi...