Dear gene regulation aficionados in the wider Copenhagen π©π°area: Please feel cordially invited to our 3rd Copenhagen Gene Regulation Seminar π¨βπ« next week on Thursday, the 5th of March. π Hope to see you in Panum for 2 exciting talks! π
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now π«ππ©π₯π’-ππππ-π¬ππͺ shows π₯π¦ π―π°π·π° chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
Join us for a day of talks, posters, and discussions, featuring a morning joint lecture with Nobel Laureates Eric F. Wieschaus and Christiane NΓΌsslein-Volhard!
Date: Monday, May 4th, 2026
Location: University of Copenhagen, Mærsk Tower
sites.google.com/view/emergin...
Free to participate
Fly model for motion sickness? π May one ask seriously though what the experiment is about. Looks super intriguing.
Working with the fantastic Governor of Louisiana, Jeff Landry, we are going to send a great hospital boat to Greenland to take care of the many people who are sick, and not being taken care of there. It's on the way!!! President DJT
Healthcare in Greenland is publicly funded, free at the point of use, and despite geographical challenges considered very good.
Healthcare costs in the USA are extortionate and responsible for 60% of all US bankruptcies.
So maybe Denmark should be sending hospital ships the other way.
Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.
Congratulations π to all the fabulous researchers that have contributed to this beautiful paper!
How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers?
Check our latest work, from @ybellaichelab.bsky.social
Congratulations to all authors.
Artwork from the artist @lale-alpar.bsky.social
(lalealpar.com)
www.cell.com/developmenta...
Black-and-white photograph of Vera Menchik, the pioneering first Women's World Chess Champion, seated at a chessboard in deep concentration during a game or study session. She rests her chin on her clasped hands, elbows on the table, gazing intently downward at the board with a calm, focused expression. Menchik has dark hair pulled back and wears a long-sleeved cardigan or sweater. The chessboard in the foreground displays a mid-game position with black and white pieces in play, including prominent kings, queens, bishops, knights, rooks, and pawns. Behind her, heavy dark curtains frame a bright window letting in natural light.
In 1927, Vera Menchik became the first Women's World Chess Champion at age 21 & is the longest-reigning women's champion in #chess history.
She defended the title 7 times, held it undisputed until her tragic death in 1944 at age 38 in a V-1 rocket bombing during #WWII. She was born #OTD in 1906.
Interested in transcriptional regulation, enhancers and 3D genome folding?
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed π§΅π
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
1/3 New bioRxiv preprint from the lab: βMinute-scale coupling of chromatin marks and transcriptional burstsβ. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...
I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that π§ͺ
We need to teach PhD students how to write a great cover letter - one that links their research to a future labβs goals, shows genuine enthusiasm, and clearly explains fit. Itβs not a CV summary or a formality; itβs their first real conversation with future colleagues.
π¨Preprint alertπ¨ How does chromatin βarchitectureβ form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
Every American needs to watch this:
A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.
Auschwitz was at the end of a process. We must remember that it did not start from gas chambers.
This hatred gradually developed: from ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
A picture of current members of the Groth lab
Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation JacobΓ¦us Prize π weβre proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition π celebrating the contributions of past & present lab members to this work too π₯³
Our work on improving human egg quality was featured in @theguardian.com.
We hope this will help to make #IVF more successful and allow more couples to conceive. π
Thanks a ton for the super informative link. Remarkable to see that many women were actually chosen for the new names. Rachel Carson - outstanding choice, indeed!
This is very encouraging to read. Presumably this was not state-/municipality-driven, but due to locals?
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
Jeg stΓ₯r her omkring i morgen fra ca. kl 10 og frem til 11:30 eller der omkring. SΓ₯ gΓ₯r turen videre til Panum. HΓ₯ber vi ses!
Tusind tak Stinus! Jeg sender informationen ud til sΓ₯ mange som mulig. Jeg undervise dog mellem 9:15 og 12:00. π«£π€ FΓΈrst og fremmest, helt og lykke pΓ₯ de sidste meter!
Tak Stinus. Det ville vΓ¦re fremragende. 100 millioner spΓΈrgsmΓ₯l π strΓΈmmer over campus lige nu, som alle prΓΈver at finde svar pΓ₯. Jeg er sikker pΓ₯, at et besΓΈg pΓ₯ din gamle hjemmebase ville hjΓ¦lpe med at finde nogle af disse. π Ses forhΓ₯bentlig mandag.
Tak for svaret. Definitivt klokken 12. Der er et krydsningspunkt i midten af NΓΈrre Campus (55.7004652, 12.5599248), hvor alle skal forbi mellem bygningerne. Tak! π
Kommer Du / I ogsΓ₯ forbi KU, mΓ₯ske endu bedrer NΓΈrre Campus? Jeg tror pΓ₯ Science er der lige i ΓΈjeblikket mange med behov for at snakke.
Diagrams of fruit fly larvae (left) and adult (right) annotated with genes expressed in different tissues, including male- or female-biased gene expressions.
A diagram providing an overview of the regulation of antimicrobial peptide and other host effector peptides by Toll and Imd signalling, alongside diagrams showing the diversity of the peptides.
A summary table illustrating sequence features common to antimicrobial peptides, and a summary table of gene families.
A diagram giving a model for the mechanisms of antimicrobial peptide and host defence peptide actions in killing microbial cells, including precise mechanisms, broader host-pathogen relationships, and non-microbicidal roles of these peptides in protecting the host.
Bizarre that our 2020 #Drosophila #AMP review already feels out of date.
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
β Ensembles of >12000 full-length human proteins
β Analysis of IDRs in >1500 TFs
π doi.org/10.1101/2025...
πΎ github.com/KULL-Centre/...
Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41...
Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon
Brief thread π
