POTS Radar

Regeneron is recruiting for a phase 2 RCT of REGN7544 (an NPR1 antagonist mAb) for POTS. They’re seeking 81 patients in Pasadena, CA; Carlsbad, CA; Nashville, TN; and Clearwater, FL clinicaltrials.gov/study/NCT065...

Many of the unregulated proteins they found in post-Covid POTS patients have also been found to be unregulated in pre-Covid POTS patients pmc.ncbi.nlm.nih.gov/articles/PMC...

This is deeply shocking and disturbing, the opposite of scientific good practice. As I see it, a group of diehards promoting a discredited treatment (exercise "therapy" for ME/CFS patients) are seeking to stifle medical progress - to protect their reputations. And Cochrane has kowtowed to them. 🧵

Hemodynamics in ME/CFS and POTS ME/CFS heavyweights van Campen, Visser and Rowe illuminate the boundary between ME/CFS and POTS.

pots-radar.ghost.io/hemodynamics...

1) There is some (cautious) excitement about this new ME/CFS paper that will soon be published.

It replicated abnormalities in B-cells that were found by 2 earlier studies, namely an increase in Immunoglobulin Heavy Variable IGHV3-30.

The +40bpm rule for POTS in kids is questionable Researchers from the USA's East coast show that requiring a 40bpm heart rate increase on standing to diagnose POTS in kids might not be fair.

pots-radar.ghost.io/the-40bpm-ru...

Important update from the European ME Coalition (EMEC) regarding European funding for ME/CFS 👇

Characterizing Autonomic Dysfunction in POTS Neurologists and engineers from Taiwan attempt to gain insight into the mechanism of autonomic dysfunction in POTS.

pots-radar.ghost.io/characterizi...

Visual symptoms in postural tachycardia syndrome A prolific group of neurologists in Bern team up with biomedical engineers for a case-controlled study of posture-dependent visual symptoms in POTS.

Visual symptoms in postural tachycardia syndrome
pots-radar.ghost.io/visual-sympt...

Not sure what to make of this (it was a single-blind study).

Press release from Dec. 19: www.biospace.com/press-releas...

Meeting abstract from Dec. 6, in the American Society of Hematology’s journal Blood: www.sciencedirect.com/science/arti...

Blood Pressure Regulation in Post–COVID POTS Artur Fedorowski and colleagues are back with a case-controlled study that used 24-hour blood pressure monitoring on 100 patients with post-COVID-19 POTS.

Blood Pressure Regulation in Post–COVID POTS
pots-radar.ghost.io/blood-pressu...

pots-radar.ghost.io/welcome/

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This is POTS Radar 📡

Follow for reviews of the latest research on Postural Orthostatic Tachycardia Syndrome (POTS).