Marie Carlén

New brain maps challenge traditional descriptions of the brain For more than a century, maps of the brain have been based on how brain tissue looks under the microscope. These anatomical maps divide the brain into regions according to structural variations in the...

For more than a century anatomical maps divide the #brain into regions according to structural variations in the tissue. But do these divisions really reflect how the brain works? A new study on mice from @ki.se suggests that this is often not the case #research #neuroscience
tinyurl.com/4jtffpc2

Nya hjärnkartor utmanar traditionella beskrivningar av hjärnan I mer än ett sekel har kartor av hjärnan baserats på hur vävnaden ser ut under mikroskop. Dessa anatomiska kartor delar upp hjärnan i regioner utifrån strukturella variationer i vävnaden. Men speglar ...

I mer än ett sekel har anatomiska kartor delat upp hjärnan i regioner utifrån strukturella variationer i vävnaden. Men speglar dessa indelningar verkligen hur hjärnan fungerar? En ny studie på möss från @ki.se tyder på att så ofta inte är fallet @carlenlab.bsky.social #forskning
tinyurl.com/2tznb2pf

It's out! Our new study (led by @pierrelemerre.bsky.social & @weltgeischt.bsky.social @carlenlab.bsky.social) challenges classical cytoarchitectonic borders in the prefrontal cortex, showing that connectivity better explains its functional organization.
Read the open-access paper here: rdcu.be/eZUkh

A prefrontal cortex map based on single-neuron activity - Nature Neuroscience The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity...

Main postdoc study out! We can redefine prefrontal cortex regions with single-unit activity! Grateful to @carlenlab.bsky.social and @weltgeischt.bsky.social who made this crazy project real. Thanks to all co-authors, collaborators, and reviewers.
www.nature.com/articles/s41...

Happy birthday to us! 🥳

In 2003, we launched with just four employees in a small, rented laboratory working together towards a big goal - map the entire mammalian brain in a way the world had never seen.

🧠📈 #OpenScienceWeek

First Patient Treated with Personalized CRISPR Therapy, Developed in Just Six Months The first on-demand CRISPR therapy for an infant with a rare metabolic disease developed by the IGI and collaborators around the world.

This is what can be achieved today due to longstanding federal support of academic basic science alongside close partnership of universities, private industry and NIH intramural initiatives. An ecosystem worth not just saving but doubling down on!

innovativegenomics.org/news/first-p...

Cancer Neuroscience Michelle Monje and Frank Winkler are awarded The Brain Prize 2025 for pioneering the field of Cancer Neuroscience.

Fantastic!! brainprize.org/winners/canc...

Research Assistant in Neuroscience Do you want to contribute to top quality medical research? The position regards experimental research in the laboratory of Professor Marie Carlén in the Department of Neuroscience. Utilizing a sy

We are hiring a research assistant! Come join our ongoing project investigating the PFC-striatum pathway in cognitive flexibility. Head-fixed behavior, Neuropixels, optogenetics, and viral circuit tracing etc ki.varbi.com/en/what:job/.... Please spread.

Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...

first thing to share here!

excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning

www.biorxiv.org/content/10.1...

I have rig and cool slice project on voltage imaging + opto, reach out and we can talk

My first on BlueSky! 5 yrs in the making, a new view on the mouse PFC, based on activity

Lovely if you could add me