Felix Kaspar

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Thanks to nomenclature rules...

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To add to that: ASR only infers from the finite number of potentially erroneous sequences you feed it. Not from the enormously large number of true sequences that exist. So outputs will be "wrong" by definition. Whether or not those outputs are still useful or insightful is a different question.

Exactly. We don't. ASR is a statistical method where uncertainties increase the further back in evolutionary time you go. You can mitigate some of that uncertainty but you'll never actually know if a reconstructed sequence ever actually existed. It probably didn't. But one similar to it may have.

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An organic chemist can do the same reaction five times and only report a single (i.e. the highest) yield.

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Meanwhile universities are issuing fines to their PI for putting too little effort into grants ... even though their proposals were successful?
🎷🔥

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Ah so that excludes fancy phosphorylated intermediates. So your students actually had to know *something* about membrane lipids...

A (!) phospholipid? Just any one? Did they have to name it or just draw a structure?

Would I get full credit for decyl phosphate? - I.e. a phosphate group with scribbles on one end? 😅

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I mean I've been to a few seminars where the speaker was fried in the discussion. But a whole symposium ... man.

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1H is fine but 31P...

I'd think so but I'm biased because I definitely helped 😅

What's the most downloaded paper though?

Bradford assay.

Sure, prep HPLC-MS is a thing. For some types of chemistry, it's almost essential equipment.

Fun! Props to you pulling out the intact compounds in the first place!

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Once the first oxidation in the alkene chain happens, hell breaks loose?

Saw this earlier on the journal homepage - really cool story and funky molecules!

Your UV data (Fig S6) look like there are at least three (?) distinct degradation pathways. Do you know what they are/might be?

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Reinterpret what they said and just answer the question you wish they would have asked?

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👀

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Nice!
'Gute Nacht Kleiner Bagger' is my (almost 2 y old) son's go-to for bedtime. The thing is I already know the text backwards because it was also my (3.5 y old) daughter's go-to book for bedtime when she was his age.

That would WILDLY inflate my total. Though a lot of those are re-reads. Or re-re-re-re-re-reads.

When you forgot to take one reagent out of the freezer.

I do recommend a Stromlight re-read once you're very cosmere-aware.

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I managed 16 last year, which is down from my pre-kids numbers but up from 2024. Since I spent most of 2025 on a full cosmere re-read (@brandonsanderson.com), almost all of those were relatively chunky fantasy books.

Mark shares a really valuable analysis here.

Plus the acronym game is top-notch.

I've seen this 31P NMR before.

Biotechnology in Brunswick had (has, I think) an English B2 level requirement to get the degree and regardless of your level you had to take at least one semester of a scientific English course.

Just out of curiosity: Is that red bull still good? Our experience has been that taurine-containing buffers do not go bad. You can leave them for years on the bench and there won't be any bacteria or fungus growing...

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Who doesn't like a tasty mouthwash? 😄

Apparently so (doi.org/10.1186/s129...).